Bringing light to pathogens : light-driven strategies for disinfection of pathogens

Abstract :

The emergence of antimicrobial resistance has prompted the search for new strategies, aiming to find more efficient ways to kill microbial pathogens. In this sense, Photodynamic Antimicrobial ChemoTherapy (PACT) uses a combination of light, oxygen and a photosensitizer molecule to produce lethal reactive oxygen species, which have demonstrated to be highly effective against microorganisms and even against multiresistant microorganisms. During this talk, I will address the different challenges that surround the field, ranging from an efficient delivery of photosensitizers using natural biopolymers, while also addressing the delivery of light into a clinical scenario model, addressing the difficulties of biological experiments with
two-variables to juggle with, technical challenges that hinder the application of this technique into the clinic.

Contact : appaixfl@univ-grenoble-alpes.fr