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DTSTART;TZID=Europe/Paris:20260227T110000
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DTSTAMP:20260515T103949
CREATED:20260129T163105Z
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UID:10000041-1772190000-1772193600@sfp-alpes.fr
SUMMARY:Jean-Francois COLLET (Institut de Duve\, Bruxelles)
DESCRIPTION:How (and Why) do Gram-Negative Bacteria build an Outer Membrane\nRésumé :  \nGram-negative bacteria are defined by a complex cell envelope in which the outer membrane plays a central role in protection\, nutrient exchange\, and antibiotic resistance. This asymmetric lipid bilayer forms a robust permeability barrier\, yet its biogenesis presents a striking challenge : all outer membrane components are synthesized in the cytoplasm or at the inner membrane and must be transported and assembled across the periplasm without direct energy input. In this talk\, I will discuss how Gram-negative bacteria build their outer membrane and why this process is essential for cellular physiology. I will introduce the major pathways responsible for outer membrane assembly and highlight how their activities need to be coordinated to maintain envelope integrity. I will also present recent work showing that the outer membrane is not merely a passive barrier\, but a mechanically active structure that enables the buildup of periplasmic pressure\, a property critical for envelope stability and bacterial survival. Together\, these findings underscore the outer membrane as a dynamic\, multifunctional organelle and a promising target for future antibacterial strategies. \nContact : ibs.seminaires@ibs.fr
URL:https://sfp-alpes.fr/event/jean-francois-collet-institut-de-duve-bruxelles/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
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