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DTSTART;TZID=Europe/Paris:20260323T110000
DTEND;TZID=Europe/Paris:20260323T120000
DTSTAMP:20260507T184642
CREATED:20260320T094540Z
LAST-MODIFIED:20260320T094546Z
UID:10000101-1774263600-1774267200@sfp-alpes.fr
SUMMARY:Chloé ROFFAY (IMP Vienna\, Austria)
DESCRIPTION:Uncovering the forces driving the fate and shape of the extraembryonic amnion during human gastrulation\nRésumé : \nExtraembryonic tissues provide key molecular signals and mechanical support to the growing embryo. For instance\, the extraembryonic amnion\, which forms a fluid-filled sac surrounding the embryo\, was recently shown to trigger germ layer specification during gastrulation\, by secreting BMP ligands. Despite the key roles of extraembryonic tissues in embryo development\, little is still known regarding their molecular and biophysical programs\, particularly in human. Using a 2D stem cell-based model of human gastrulation\, termed gastruloid discs\, we found that amnion cells undergo a sharp columnar-to-squamous transition concomitantly with fate specification. Via biophysical modelling\, direct force measurements\, pharmacological and genetic perturbations\, we showed that this morphogenetic transition is amnion-intrinsic and it is driven by active wetting\, i.e. a transition from tensile to adhesion-dominated cellular states. Molecularly\, active wetting is implemented via a rewiring of cytoskeleton composition\, from actomyosin to keratin-based cytoskeletal networks\, akin to a bistable toggle-switch in gene regulatory networks. Strikingly\, blocking shape changes at the colony edge results both in defective cellular states in the amnion and impaired gastruloid disc morphogenesis within the embryonic compartment. Together\, our findings establish that a cytoskeletal toggle switch couples fate specification to tissue architecture in the human amnion and suggest an unexpectedly active mechanical role for extraembryonic tissues in shaping the embryo proper. \nContact : thomas.boudou@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/chloe-roffay-imp-vienna-austria/
LOCATION:LiPhy – Salle de conférence\, LiPhy 140 avenue de la Physique\, St Martin d'Hères\, 38402\, France
CATEGORIES:Séminaire
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DTSTART;TZID=Europe/Paris:20260323T140000
DTEND;TZID=Europe/Paris:20260323T150000
DTSTAMP:20260507T184642
CREATED:20260306T161739Z
LAST-MODIFIED:20260306T162442Z
UID:10000098-1774274400-1774278000@sfp-alpes.fr
SUMMARY:Stéphanie ROCCIA (LPSC-CNRS/UGA\, GRENOBLE)
DESCRIPTION:The search for neutron electric dipole moment at PSI\nRésumé : \nThe Universe and its history are simultaneously very well understood and still a big mystery. We have amazing tools from satellites to\nobservatories to weight the universe over its history. But the components of the Universe can simply not yet be explained by physicists. To get the full picture\, we need to identify and understand the interactions at play throughout the life of the Universe. This is the meeting point between particle physics and cosmology. At this meeting point stands the neutron\, a common particle that we can uniquely use in high precision experiments.\nI will present how experiments searching for a permanent electric dipole moment of the neutron (nEDM) aim at discovering new sources of CP violation beyond the Standard Model of particle physics and understanding the origin of the matter-antimatter asymmetry of the Universe. The quest for the neutron electric dipole moment started more than sixty years ago. In recent experiments\, polarized ultra-cold neutrons are stored in material bottles.\nI will present the ongoing efforts at the Paul Scherrer Institute in Switzerland where the n2EDM spectrometer has taken the first “physics data” in 2025. A large fraction of this dataset is dedicated to measurements of the UCN spectrum. I will present the newest UCN spectroscopy techniques that were recently published and the reasons for the importance of a deep understanding of the UCN spectrum. \n— \nHanno Filter (College 3 Secretary) \nExternal visitors may ask for a site access to tellier(at)ill.fr \nZoom link : https://ill.zoom.us/j/98964195699?pwd=vPhNT17CAeoDUr7QX4PjfyPnWsHuMU.1 – Password : SeminarC3
URL:https://sfp-alpes.fr/event/stephanie-roccia-lpsc-cnrs-uga-grenoble-2/
LOCATION:ILL – Salle de Séminaire (110-111)\, ILL 50 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
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