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DTSTART;TZID=Europe/Paris:20260506T110000
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DTSTAMP:20260502T001518
CREATED:20260430T140156Z
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UID:10000144-1778065200-1778068800@sfp-alpes.fr
SUMMARY:Tiffany HO (Lab of Prof Brian Wilson at the Princess Margaret Cancer Center\, Toronto\, Canada)
DESCRIPTION:Redefining photodynamic therapy beyond local : Nanoparticle-enabled photodynamic-immune stimulation for treatment of hot and cold cancers\nRésumé : \nPhotodynamic therapy (PDT) is a cancer-treatment modality that\, under the appropriate treatment parameters\, can induce immunogenic tumor cell death and stimulate anti-tumor immunity (photodynamic immune stimulation\, PDIS). This has the potential to prime adaptive immune responses capable of targeting distant\, untreated lesions\, as well as eradicating primary treated tumor. The clinical impact of PDT has been limited by conventional photosensitizers\, which often exhibit poor tumor selectivity and insufficient immune activation. Nanomedicine-based photosensitizer platforms offer a promising strategy to overcome such limitations. Porphysomes (PS)\, a class of all-organic\, multifunctional porphyrin-lipid nanoparticles currently in Phase I clinical trials for positron emission tomography (PET) imaging of metastatic gynecological cancers\, represent one such platform. \nThis seminar will focus on our work investigating PS-PDIS to drive systemic anti-tumor immunity across tumor models of different immunogenicity\, including immunologically “hot” colorectal (CT26) tumors and “cold” melanoma (B16F10) and ovarian (ID8) tumors. The findings establish a strategy to expand PDT beyond localized tumor ablation toward systemic disease control\, including prevention of recurrence and metastasis in cold tumors typically resistant to conventional immunotherapies. The seminar will also highlight ongoing efforts to develop gold nanocluster-based platforms for both light- and radiation-mediated immune stimulation in pancreatic cancer\, further expanding the scope of nanomaterial-enabled photodynamic and radiodynamic immune stimulation. \nThis work was supported by the Terry Fox Research Institute (PPG 1137) and the Government of Canada’s New Frontiers in Research Fund (NFRF) (#NFRFT-2020-00573). » \n_ \nContact : anne-laure.bulin@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/tiffany-ho-lab-of-prof-brian-wilson-at-the-princess-margaret-cancer-center-toronto-canada/
LOCATION:IAB – Salle de séminaire\, IAB Site Santé - Allée des Alpes\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IAB":MAILTO:appaixfl@univ-grenoble-alpes.fr
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DTSTART;TZID=Europe/Paris:20260506T113000
DTEND;TZID=Europe/Paris:20260506T123000
DTSTAMP:20260502T001518
CREATED:20260430T115832Z
LAST-MODIFIED:20260430T120458Z
UID:10000138-1778067000-1778070600@sfp-alpes.fr
SUMMARY:Adeline LACROIX (Centre for Addiction and Mental Health\, Toronto\, Canada)
DESCRIPTION:Towards an Understanding of Sex Differences in Socio-Emotional Processing in Autism\nRésumé : \nAutism is characterized by persistent difficulties in social interaction and social cognition. These difficulties are partly related to atypical processing of socio-emotional signals\, including emotional facial expressions. Although core autistic characteristics are observed in both males and females\, increasing evidence suggests that autistic females often show a more subtle socio-emotional profile\, marked by greater attention to social stimuli and more typical-appearing social behavior. However\, this profile remains insufficiently characterized\, and the underlying neurobiological mechanisms are still poorly understood.\n\nGiven the central role of face processing in social cognition\, we conducted a series of behavioral and EEG studies to investigate sex differences in autism during face processing at different stages of attentional processing. Our results reveal sex-related differences in autism from early stages of face processing\, with autistic females showing an intermediate profile between autistic males and non-autistic females. Together\, these findings indicate that aggregating males and females may obscure meaningful neurocognitive differences in socio-emotional processing and highlight the need for sex-informed experimental designs and theoretical frameworks in autism research. They further suggest that early differences in socio-emotional processing may contribute to the subtler phenotypic presentation of autism in females.\n_\nContact : michael.pereira@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/adeline-lacroix-centre-for-addiction-and-mental-health-toronto-canada/
LOCATION:GIN – Amphi Serge Kampf\, Grenoble Institut des Neurosciences (GIN) Bât. Edmond J. Safra\, Chemin Fortune Ferrini CHU\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
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