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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261112T080000
DTEND;TZID=Europe/Paris:20261112T090000
DTSTAMP:20261023T092824Z
CREATED:20261023T092824Z
LAST-MODIFIED:20261023T092824Z
UID:10000320-1794470400-1794474000@sfp-alpes.fr
SUMMARY:Mathieu VAILLANT (service : Neurologie)
DESCRIPTION:Hypnose thérapeutique et douleur lors des ponctions lombaires : étude randomisée\n_ \nContact : sante-communication@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/mathieu-vaillant-service-neurologie/
LOCATION:CHU – Salle Gilbert Faure\, CHU Grenoble Alpes Pavillon Vercors (côté Belledonne)\, La Tronche\, 38043\, France
CATEGORIES:Séminaire
ORGANIZER;CN="CHU Grenoble":MAILTO:sante-communication@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261112T130000
DTEND;TZID=Europe/Paris:20261112T140000
DTSTAMP:20261102T231313Z
CREATED:20261102T231313Z
LAST-MODIFIED:20261102T231313Z
UID:10000341-1794488400-1794492000@sfp-alpes.fr
SUMMARY:Annabelle BALLESTA (Institut Curie\, Paris)
DESCRIPTION:Systems pharmacology and machine learning for optimizing treatments of brain tumors\nRésumé : \nGlioblastoma (GBM)\, the most frequent and aggressive brain tumor inadults\, is associated with a dismal prognostic despite intensive treatment involving surgery\, radiotherapy and temozolomide (TMZ)-based chemotherapy. The initial or acquired resistance of GBM to TMZ appeals for precision medicine approaches for the design of novel efficient\ncombination pharmacotherapies. To that end\, a comprehensive approach combining quantitative systems pharmacology (QSP) and machine learning was undertaken to design TMZ-based drug combinations circumventing the initial resistance to the alkylating agent. A QSP model representing TMZ cellular pharmacokinetics- pharmacodynamics and dysregulated pathways in GBM based on ordinary differential equations was developed and validated using multi-type time- and dose-resolved datasets. In silico drug screening based on numerical optimization and subsequent experimental validation identified a strategy to re-sensitize TMZ-resistant cells consisting in combining TMZ with inhibitors of the base excision repair and of homologous recombination. Using machine learning\, model parameters driving response to such optimal multi-agent therapy were derived to assist decision making in patients. Thus\, we successfully demonstrated the relevance of combined QSP and machine learning to design efficient drug combinations re-sensitizing glioblastoma cells initially resistant to TMZ. The developed framework may further serve to identify personalized therapies and administration schedules by extending it to account for additional patient-specific altered pathways and whole-body features. \n_ \nContact : antoine.frenoy@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/annabelle-ballesta-institut-curie-paris/
LOCATION:IMAG – Salle de Réunion\, 150 place du Torrent\, St Martin d’Hères\, 38400\, France
CATEGORIES:Séminaire
ORGANIZER;CN="TIMC - IMAG":MAILTO:lucie.lamothe@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261112T140000
DTEND;TZID=Europe/Paris:20261112T150000
DTSTAMP:20261023T142909Z
CREATED:20261023T142909Z
LAST-MODIFIED:20261023T142909Z
UID:10000323-1794492000-1794495600@sfp-alpes.fr
SUMMARY:Pierre PUJOL (LPT\, Univ. Toulouse)
DESCRIPTION:Skyrmions\, bimerons and their effect on itinerant electrons\nRésumé : \nMagnetic skyrmions and bimerons are topological spin textures that exhibit remarkable stability at finite temperatures. In this talk we will discuss a variety of models exhibiting different phases (fluid and crystallines) of these topological spin textures that are tunable with temperature\, magnetic field or strain. We’ll also discuss their effect on itinerant electrons\, and in particular the presence of bound states and one dimensional (i.e.\, like edge) electronic transport. \n_ \nContact : elsa.lhotel@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/pierre-pujol-lpt-univ-toulouse/
LOCATION:CNRS – Salle Rémy Lemaire (K223)\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261112T140000
DTEND;TZID=Europe/Paris:20261112T150000
DTSTAMP:20261101T230400Z
CREATED:20261101T230243Z
LAST-MODIFIED:20261101T230400Z
UID:10000331-1794492000-1794495600@sfp-alpes.fr
SUMMARY:Hélène CASTEBRUNET (maître de conférence UGA) & Gérémy PANTHOU (physicien-adjoint CNAP à l’Institut des Géosciences de l’Environnement (Grenoble))
DESCRIPTION:Eau dans le Y Grenoblois : reste-t-il une seule goutte qui n’ait pas été impactée par les activités humaines ?\nRésumé : \nA venir… \n_ \nContact : yvonne.soldo@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/helene-castebrunet-maitre-de-conference-uga-geremy-panthou-physicien-adjoint-cnap-a-linstitut-des-geosciences-de-lenvironnement-grenoble-2/
LOCATION:CNRS – Bâtiment A\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
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