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X-WR-CALDESC:Évènements pour SFP Alpes
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DTSTART;TZID=Europe/Paris:20261211T000000
DTEND;TZID=Europe/Paris:20261212T235959
DTSTAMP:20261106T160452Z
CREATED:20261023T151109Z
LAST-MODIFIED:20261106T160452Z
UID:10000325-1796947200-1797119999@sfp-alpes.fr
SUMMARY:Pièce de Theâtre Supraconducteur
DESCRIPTION:  \nLa SFP Alpes co-organise la venue du Spectacle Supraconducteur co-écrit et co-joué par notre collègue du CEA Hugues Pothier\, et nos nouveaux lauréats du Prix Jean Perrin le Groupe N+1 : plusieurs représentation entre le Vendredi 11 et Samedi 12 Décembre (save ze date !) \nEn savoir plus…
URL:https://sfp-alpes.fr/event/piece-de-theatre-supraconducteur/
LOCATION:MJC Allobroges – salle Stendhal\, 5 rue Hauquelin\, Grenoble\, 38000\, France
CATEGORIES:Evènements
ORGANIZER;CN="SFP Alpes":MAILTO:contact@sfp-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261214T090000
DTEND;TZID=Europe/Paris:20261218T160000
DTSTAMP:20261002T143158Z
CREATED:20261002T142004Z
LAST-MODIFIED:20261002T143158Z
UID:10000293-1797238800-1797609600@sfp-alpes.fr
SUMMARY:School on Neutron Diffraction Data Treatment using the FullProf Suite
DESCRIPTION:We are delighted to announce the 2026 School on Neutron Diffraction Data Treatment using the FullProf Suite\, which will take place at the Institut Laue-Langevin (ILL) in Grenoble\, France\, from 14 to 18 December 2026. \nThis Edition will place a special emphasis on the analysis of magnetic structures\, alongside the treatment of both X-ray and neutron diffraction data. The school is designed to provide in-depth\, hands-on training using the FullProf Suite\, with a balance of tutorials and lectures delivered by experts in the field. \n🔗 Further details and application: \nVisit our website at: https://workshops.ill.fr/e/FullProfSchool2026 \nRegistration is open and we warmly encourage you to register for this School. \n🎯 Scientific Scope \nThe 2026 FullProf School aims to train scientists in the effective treatment of X-ray and neutron diffraction data\, with a particular focus on magnetic structure determination and the latest features in materials science data analysis. \nParticipants will benefit from intensive practical sessions\, making extensive use of the FullProf Suite\, complemented by targeted lectures that cover the theoretical background necessary for intermediate-level users. \n🎯 Lectures & Tools \nThis session will highlight the use of FullProf Suite in combination with external tools such as the Bilbao Crystallographic Server and ISODISTORT\, especially for applications related to magnetic structures. \n👥 Who Should Apply? \nThe school is intended for PhD students and experienced researchers with a solid background in powder diffraction and/or single crystal crystallography. To ensure personalized support and effective interaction\, the number of participants is limited to 30. \nPlaces will be allocated on a first-come\, first-served basis\, and registration will only be confirmed upon receipt of payment. Once capacity has been reached\, additional applicants will be placed on a waiting list. \nWe would appreciate it if you could forward this announcement to colleagues or students who may be interested. \nWe apologize if you receive this message more than once\, and look forward to welcoming you in Grenoble! \n_ \nContact : FPSschool@ill.fr
URL:https://sfp-alpes.fr/event/school-on-neutron-diffraction-data-treatment-using-the-fullprof-suite/
LOCATION:ILL 50 building – room 110\, EPN Campus - 71 avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Ecole,Evènements
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261215T140000
DTEND;TZID=Europe/Paris:20261215T160000
DTSTAMP:20261104T205131Z
CREATED:20261104T205131Z
LAST-MODIFIED:20261104T205131Z
UID:10000349-1797343200-1797350400@sfp-alpes.fr
SUMMARY:Jean-Maxime SCHLACHTER (IRIG / PHELIQS)
DESCRIPTION:Local electronic properties of few-layer NbSe2 and 30°-twisted bilayer graphene\nRésumé : à venir… \n_ \nContact : jean-maxime.schlachter2@cea.fr
URL:https://sfp-alpes.fr/event/jean-maxime-schlachter-irig-pheliqs/
LOCATION:CEA – Grenoble (bâtiment C5 – salle 421A)\, 17\, avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261215T140000
DTEND;TZID=Europe/Paris:20261215T160000
DTSTAMP:20261106T154824Z
CREATED:20261106T154824Z
LAST-MODIFIED:20261106T154824Z
UID:10000353-1797343200-1797350400@sfp-alpes.fr
SUMMARY:Soutenance de Thèse par Zeinab EL DOR​ (CEA-Irig/BGE)
DESCRIPTION:Modelling Pigmentary Dysregulation in Xeroderma Pigmentosum C via XPC-deficient Skin Cells and Pigmented Reconstructed Skin Models\nRésumé : \nXeroderma pigmentosum group C (XP-C) is a rare autosomal recessive genodermatosis stemming from mutations in XPC\, the damage-recognition factor of global genome nucleotide excision repair. Patients exhibit extreme photosensitivity and a drastically increased susceptibility to skin malignancies. Pigmentary abnormalities\, such as lentigines and hyperpigmentation of sun-exposed skin\, remain largely underexplained\, although they are the earliest clinical signs of the disease. Existing XP-C models have focused on DNA repair and carcinogenesis\, while the pigmentary aspect of the disease has received little attention. This project was designed to characterize that aspect\, from the melanocyte itself to its epidermal microenvironment. \nOur work examined the molecular consequences of XPC loss in melanocytes through quantitative proteomics (LC-MS/MS) of wild-type and previously established XPC-knockout (XPC-KO) human melanocytes\, in the presence and the absence of UVB exposure. Unsupervised clustering\, functional enrichment and protein interaction network analyses converged on a constitutive type I interferon signal in XPC-KO melanocytes and confirmed by immunoblotting. While wild-type melanocytes reached comparable levels only after UVB exposure\, XPC-deficient melanocytes carry\, in the absence of any stress\, an interferon response that normal cells mount only under genotoxic stress. Pharmacological JAK inhibition modified neither the UVB sensitivity nor the photoproduct repair defect of XPC-KO melanocytes\, suggesting that this inflammatory phenotype accompanies rather than causes the DNA repair phenotype. To study pigmentation in a physiologically relevant context\, we then developed a pigmented full-thickness reconstructed human skin model in which melanocytes synthesize melanin and transfer it to the epidermal layers without UV. We then implemented the pigmented epidermal model to explore the impact of XPC-deficient microenvironment on the overall pigmentary phenotype. Combining XPC-KO or wild-type keratinocytes with the same pigmented melanocytes made it possible to detect the contribution of the XP-C epidermal microenvironment. XP-C keratinocytes were sufficient to induce a marked hyperpigmentation of wild-type melanocytes\, with increased melanin content and tyrosinase activity. This suggests that the distinct pigmentary feature of XP-C is not exclusively melanocyte-autonomous but is driven\, at least in part\, by the keratinocyte microenvironment. Treatment of the epidermal equivalents with JAK inhibitors or with N-acetylcysteine partially attenuated this hyperpigmentation\, pointing to an inflammatory component that contributes to\, without fully accounting for\, the phenotype. \nTogether\, these results identify a constitutive type I interferon signature as a hallmark of XPC deficiency in melanocytes and reveal the XP-C keratinocyte microenvironment as a trigger of hyperpigmentation with an inflammatory arm. Beyond XP-C\, the naturally pigmented skin model developed during this work provides a platform for studying keratinocyte–melanocyte crosstalk in pigmentary disorders. This work extends the understanding of XP-C beyond DNA repair and identifies the epidermal microenvironment as a potential target to modulate the pigmentary manifestations of the disease. \n_ \nATTENTION ! L’entrée d​u site CEA-Grenoble nécessite une autorisation préalable et sur présentation de votre pièce d’identité le jour de votre venue (CI ou passeport\, car le permis de conduire n’est pas recevable). Veuillez nous contacter par mail​​ \n​Note : Entry to the CEA-Grenoble site requires prior authorization and the presentation of your ID on the day of your visit (ID card or passport; driver’s licenses are not accepted). Please request this authorization by​ e-mail​ \n\n\n\n\n\n  \n\n\n\n\n​
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-zeinab-el-dor-cea-irig-bge/
LOCATION:CEA – Salle de Séminaire IRIG (1005 – 445)\, 17\, avenue des Martyrs\, Grenoble\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261216T123000
DTEND;TZID=Europe/Paris:20261216T133000
DTSTAMP:20260723T165459Z
CREATED:20260723T165117Z
LAST-MODIFIED:20260723T165459Z
UID:10000220-1797424200-1797427800@sfp-alpes.fr
SUMMARY:Roland LEHOUCQ
DESCRIPTION:Science-fiction : le monde de la (dé)mesure\n_ \nToutes les informations sont disponibles sur : https://indico.ijclab.in2p3.fr/event/13626/ \nContact : louis.fayard@IJCLAB.INP3.FR
URL:https://sfp-alpes.fr/event/roland-lehoucq/
LOCATION:Université Paris-Saclay – Bâtiment 625 (Hbar) – Amphi A1\, Rue Joliot Curie\, Orsay\, 91400\, France
CATEGORIES:Séminaire
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261218T090000
DTEND;TZID=Europe/Paris:20261218T110000
DTSTAMP:20261002T135937Z
CREATED:20261002T135937Z
LAST-MODIFIED:20261002T135937Z
UID:10000292-1797584400-1797591600@sfp-alpes.fr
SUMMARY:Soutenance de thèse par Francesca MOSCA (CEA-Irig/IBS)
DESCRIPTION:Targeting L\,D-Transpeptidases in Lpp-Peptidoglycan Crosslinking in E.coli\nRésumé : \nThis thesis investigated the structure and function of L\,D-transpeptidases (LDTs) responsible for covalently attaching Braun’s lipoprotein (Lpp) to the peptidoglycan layer in Gram-negative bacteria. Because Lpp constitutes the principal covalent connection between the peptidoglycan and the outer membrane\, disruption of this linkage destabilises the bacterial cell envelope. Understanding the molecular mechanisms underlying LDT-mediated Lpp attachment therefore provides a foundation for developing novel inhibitors capable of compromising outer-membrane integrity and enhancing the activity of existing antibiotics against antibiotic-resistant Gram-negative bacteria. The work focused on mainly two aspects of LDT function : the interactions of these enzymes with existing and novel antibiotics\, and with their physiological substrates Lpp and peptidoglycan. Particular emphasis was placed on LdtB\, the most essential LDT in E. coli. Structural and functional characterization was performed using NMR spectroscopy\, biophysical methods\, and biochemical techniques\, complemented by in silico approaches\, including molecular dynamics simulations.This integrative approach was used to decipher the molecular determinants of Lpp-peptidoglycan transpeptidation mechanism and to propose a possible stuctural model for the reaction\, which remains poorly understood despite its biological relevance. In this context\, E. coli served as a model system\, whose study may provide insights into mechanisms that could be conserved across other Gram-negative bacteria. This work was carried out within the framework of the BREAKthrough consortium\, which enabled part of the research to be conducted in collaboration with partner laboratories across Europe​. ​​​​ \n_ \n\n\n​Les séminaires et soutenances sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire  et de l’adresser\, plus de 48h à l’avance\, à ce contact. \n\n\n\n\nPensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-francesca-mosca-cea-irig-ibs/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20270114T160000
DTEND;TZID=Europe/Paris:20270114T170000
DTSTAMP:20260723T165928Z
CREATED:20260723T165928Z
LAST-MODIFIED:20260723T165928Z
UID:10000221-1799942400-1799946000@sfp-alpes.fr
SUMMARY:Emilia ROBIN
DESCRIPTION:Comment on a construit Orsay\n_ \nToutes les informations sont disponibles sur : https://indico.ijclab.in2p3.fr/event/13925/ \nContact : louis.fayard@IJCLAB.INP3.FR
URL:https://sfp-alpes.fr/event/emilia-robin/
LOCATION:Laboratoire IJCLab – Auditorium Pierre Lehmann\, Rue Ampère\, Orsay cedex\, 91898\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20270627T000000
DTEND;TZID=Europe/Paris:20270701T235959
DTSTAMP:20261015T133306Z
CREATED:20260227T160121Z
LAST-MODIFIED:20261015T133306Z
UID:10000090-1814054400-1814486399@sfp-alpes.fr
SUMMARY:European Conference on Neutron Scattering
DESCRIPTION:We are delighted to announce that abstract submission for ECNS 2027 is now open.\n\nhttps://www.ecns2027.eu/program/ \nThe European Conference on Neutron Scattering will take place from June 28 to July 1\, 2027\, at the Université Grenoble Alpes in the heart of the French Alps. The ECNS typically brings together more than 600 participants from across Europe and beyond. \nWe warmly invite you to contribute to the scientific programme by submitting your latest results\, ideas and perspectives. Whether you are working on applications of neutron techniques or exploring new scientific directions\, we look forward to sharing and discussing your work with the community. \nBeyond the scientific programme\, ECNS 2027 will offer plenty of opportunities to meet colleagues\, exchange ideas and discover Grenoble and its unique scientific and Alpine environment \nWe look forward to receiving your abstracts and welcoming you to Grenoble in 2027 !  \n_ \nContact : ecns2027_contact@ill.eu
URL:https://sfp-alpes.fr/event/european-conference-on-neutron-scattering/
LOCATION:Université Grenoble Alpes (UGA)\, 621 avenue Centrale\, Saint-Martin-d'Hères\, 38400\, France
CATEGORIES:Conférence,Evènements
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