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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260306T110000
DTEND;TZID=Europe/Paris:20260306T120000
DTSTAMP:20260227T091022Z
CREATED:20260227T090909Z
LAST-MODIFIED:20260227T091022Z
UID:10000076-1772794800-1772798400@sfp-alpes.fr
SUMMARY:Kilian FRABOULET (Max Planck Institute Stuttgart)
DESCRIPTION:Competing orders in many-electron systems: a renormalization group perspective\nRésumé :  \nThe renormalization group is an established approach to study quantum many-body systems\, and this applies especially to one of its modern implementations known as the functional renormalization group (fRG). In particular\, the fRG constitutes a flexible and unbiased tool for the study of competing orders. In this talk\, I will outline recent progress in this direction for correlated electron systems. To this end\, I will first discuss the competition between antiferromagnetism\, charge density waves and superconductivity in the 2D Hubbard model\, thus making a connection with high-temperature superconductors. The special role of bosonization methods will be emphasized along the way. I will also show how the fRG can be combined with dynamical mean-field theory to treat strongly interacting regimes\, with a focus on d-wave superconductivity. As a next step\, I will increase the complexity of the model by including non-local interactions and discuss unconventional superconductivity in an extended Hubbard model with a connection to moiré materials. Special consideration will also be given to the treatment of retarded interactions with electron-phonon couplings. Finally\, I will highlight recent fRG studies of quantum criticality in Dirac materials\, with a connection to graphene. \nContact : serge.florens@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/kilian-fraboulet-max-planck-institute-stuttgart/
LOCATION:LPMMC – salle Roger Maynard (G421)\, CNRS - LPMMC 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260306T140000
DTEND;TZID=Europe/Paris:20260306T150000
DTSTAMP:20260305T145620Z
CREATED:20260305T145615Z
LAST-MODIFIED:20260305T145620Z
UID:10000093-1772805600-1772809200@sfp-alpes.fr
SUMMARY:Carlo PIFFERI (Centre de Biophysique Moléculaire\, Orléans)
DESCRIPTION:Exploiting disulfide-rich peptides as protein epitope mimics : development of a generalizable conjugation approach for immunogen preparation\nRésumé : \nGeneration of specific antibodies against peptides by immunization requires their covalent conjugation to protein carriers to override their inherently weak immunogenicity. The vast majority of bioconjugation approaches to achieve peptide-protein constructs rely on thiol-maleimide chemistry1 and capitalize on a wide array of commercial maleimide-functionalized protein carriers. Disulfide-rich peptides2 (DRPs) possess a rigid\, constrained structure that makes them ideal for designing synthetic mimics of protein regions/domains. For bioconjugation purposes\, the introduction of a single spare thiol moiety into a linear peptide antigen is straightforward\, while DRPs’ disulfide bonds are prone to intramolecular thiophilic attack by the reactive thiolate. This unintended reactivity competes with the desired Michael addition to the maleimide moiety\, ultimately disrupting the native disulfide bridging framework. As a result\, DRP’s tertiary structure will be altered\, affording an immunogen that is a poor mimic of the native target. Although a few studies have explored the late-stage introduction of thiol-containing cross-linkers onto DRP antigens for their conjugation onto protein carriers\,3\,4 the stability of DRP’s disulfide pattern in the presence of an extra thiol has never been examined. To address this\, we systematically evaluated the influence of different spacers in “DRP-spacer-thiol” constructs\, under thiol-maleimide reaction conditions.5 Our results highlight how both linker length and flexibility are key to maintain DRP disulfides unaltered\, providing a general approach to achieve DRP bioconjugation by thiol-maleimide chemistry. We have applied our approach to a small DRP predicted to closely mimic a surface-accessible epitope of the full LINGO-1 protein\, and obtained a very specific antibody response upon immunization: the resulting polyclonal IgG was able to selectively bind the full-length protein in a cellular context\, with stringent selectivity across its four homologs. \nReferences : \n1. M. Góngora-Benítez\, J. Tulla-Puche & F. Albericio\, Chem. Rev. 2014\, 114\, 901–926.\n2. K. Renault\, J. W. Fredy\, P.-Y. Renard & C. Sabot\, Bioconjug. Chem. 2018\, 29\, 2497–2513.\n3. H. Katayama & M. Mita\, Bioorganic Med. Chem. 2016\, 24\, 3596–3602.\n4. H. Katayama\, R. Mizuno & M. Mita\, Biosci. Biotechnol. Biochem. 2019\, 83\, 1791–1799.\n5. L. Azzoug et al.\, ChemRxiv 2025\, DOI:10.26434/chemrxiv-2025-krjcm \n_ \nContact : david.goyard@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/carlo-pifferi-centre-de-biophysique-moleculaire-orleans/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260309T140000
DTEND;TZID=Europe/Paris:20260309T150000
DTSTAMP:20260213T084947Z
CREATED:20260213T084947Z
LAST-MODIFIED:20260213T084947Z
UID:10000063-1773064800-1773068400@sfp-alpes.fr
SUMMARY:Marek BARTKOWIAK (Paul Scherrer Institut)
DESCRIPTION:Spin-orbit control of antiferromagnetic domains without a Zeeman coupling\nRésumé : \nEncoding information in antiferromagnetic (AFM) domains is a promising solution for the ever growing demand in magnetic storage capacity. The absence of a macroscopic magnetization avoids crosstalk between different domain states\, enabling ultrahigh density spintronics while being detrimental to the domain detection and manipulation. Disentangling these merits and disadvantages seemed so far unattainable. We report evidence for a new AFM domain selection mechanism based on non Zeeman susceptibility anisotropy induced by the relative orientation of external magnetic fields to the k-domains. Consequently\, the charge transport response is controlled by the rotation of the magnetic field and a pronounced anisotropic magnetoresistance is found in the AFM phase of bulk materials Nd$_{1−x}$Ce$_x$xCoIn$_5$. Our results and the domain switching theory indicate that this constitutes a new effect which might be universal across multiband materials. It provides a novel mechanism to control and detect AFM domains\, opening new perspectives for AFM sprintronics. \nContact : andrew.fefferman@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/marek-bartkowiak-paul-scherrer-institut/
LOCATION:CNRS – Salle Louis Weil (E424)\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260310T000000
DTEND;TZID=Europe/Paris:20260313T235959
DTSTAMP:20260124T041637Z
CREATED:20260324T041304Z
LAST-MODIFIED:20260124T041637Z
UID:10000032-1773100800-1773446399@sfp-alpes.fr
SUMMARY:Synergies in High Resolution Spectroscopy workshop (HIRES2026)
DESCRIPTION:The workshop will bring together researchers in the fields of neutron spin-echo\, backscattering\, and time-of-flight (TOF) spectroscopy. It aims to highlight the strengths and synergies of these techniques\, while also showcasing their interplay with other non-neutron-based methods. \nParticipation is not limited to neutron experts\, users of complementary techniques who wish to expand their research toward neutron scattering are also warmly welcome. \nAbstract submission deadline is 30 November 2025. \nFor full details please visit the website of the workshop: https://workshops.ill.fr/e/HIRES2026 \n  \nIf you have any questions don’t hesitate to contact the Organising Committee by e-mailing to hires@ill.fr \n 
URL:https://sfp-alpes.fr/event/synergies-in-high-resolution-spectroscopy-workshop-hires2026/
LOCATION:ILL – Salle de Séminaire (SB-036)\, ILL 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260310T083000
DTEND;TZID=Europe/Paris:20260313T120000
DTSTAMP:20260206T095155Z
CREATED:20260206T095155Z
LAST-MODIFIED:20260206T095155Z
UID:10000055-1773131400-1773403200@sfp-alpes.fr
SUMMARY:Synergies in High Resolution Spectroscopy workshop (HIRES2026)
DESCRIPTION:The workshop will bring together researchers in the fields of neutron spin-echo\, backscattering\, and time-of-flight (TOF) spectroscopy. It aims to highlight the strengths and synergies of these techniques\, while also showcasing their interplay with other non-neutron-based methods. \nParticipation is not limited to neutron experts\, users of complementary techniques who wish to expand their research toward neutron scattering are also warmly welcome. \nFor full details please visit the website of the workshop : https://workshops.ill.fr/e/HIRES2026 \nIf you have any questions don’t hesitate to contact the Organising Committee by e-mailing to hires@ill.fr \n_ \nContact : HIRES2026@ill.fr
URL:https://sfp-alpes.fr/event/synergies-in-high-resolution-spectroscopy-workshop-hires2026-2/
LOCATION:ILL 4\, Grenoble\, 38000\, France
CATEGORIES:Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260310T140000
DTEND;TZID=Europe/Paris:20260310T150000
DTSTAMP:20260226T163953Z
CREATED:20260226T163942Z
LAST-MODIFIED:20260226T163953Z
UID:10000074-1773151200-1773154800@sfp-alpes.fr
SUMMARY:François PARMENTIER (Laboratoire de physique de l'école normale supérieure)
DESCRIPTION:Quantized heat flow in the Hofstadter butterfly\nRésumé : \nWhen subjected to a strong magnetic field\, electrons on a two-dimensional lattice acquire a fractal energy spectrum called Hofstadter’s butterfly. In addition to its unique recursive structure\, the Hofstadter butterfly is intimately linked to non-trivial topological orders\, hosting a cascade of ground states characterized by non-zero topological invariants. These states\, called Chern insulators\, are usually understood as replicas of the ground states of the quantum Hall effect\, with electrical and thermal conductances that should be quantized\, reflecting their topological order. The Hofstadter butterfly is now commonly observed in van-der-Waals heterostructures-based moiré superlattices. However\, its thermal properties\, particularly the quantized heat flow expected in the Chern insulators\, have not been investigated\, potentially questioning their similarity with standard quantum Hall states. Here we probe the heat transport properties of the Hofstadter butterfly\, obtained in a graphene / hexagonal boron nitride moiré superlattice. We observe a quantized heat flow\, uniquely set by the topological invariant\, for all investigated states of the Hofstadter butterfly: quantum Hall states\, Chern insulators\, and even symmetry-broken Chern insulators emerging from strong electronic interactions. Our work firmly establishes the universality of the quantization of heat transport and its intimate link with topology. A. Zhang\, et al.\, arXiv:2601.05694 (2026) \nContact : equipe-seminaires-nano@listes.grenoble.cnrs.fr
URL:https://sfp-alpes.fr/event/francois-parmentier-laboratoire-de-physique-de-lecole-normale-superieure/
LOCATION:CNRS – Salle Rémy Lemaire (K223)\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260311T110000
DTEND;TZID=Europe/Paris:20260311T120000
DTSTAMP:20260305T143844Z
CREATED:20260305T143839Z
LAST-MODIFIED:20260305T143844Z
UID:10000092-1773226800-1773230400@sfp-alpes.fr
SUMMARY:Tymoteusz TULA (LPMMC\, CNRS\, Grenoble)
DESCRIPTION:One-to-one correspondence between two-point correlators and entanglement in magnetic systems\nRésumé : \nThere are multiple measures of multipartite entanglement — including entanglement in thermal mixtures — currently used to study many-body interacting systems. Recently\, Quantum Fisher Information has been proposed as a multipartite entanglement measure that can be connected to experimentally accessible observables. In this talk\, I will present our recent findings about a one-to-one correspondence between two-point correlators and a certain general class of Heisenberg-like Hamiltonians and wavefunctions. This is a foundation of our claim that a mapping from finite-temperature observables to any entanglement measure exists for such systems. Furthermore\, I will present our results of training a convolutional neural network (CNN) to recognize and predict the entanglement for one-dimensional anisotropic XY and XYZ models\, which exhibit an entanglement transition. From our preliminary results we found that entanglement can be accurately predicted by a CNN using both static and dynamical correlators\, even when the network is trained on only a fraction of the full dataset or on data from a different system than the one used for prediction. Specifically\, when trained on observables from an anisotropic XY model\, accurate predictions can be achieved using only about 3% (6%) of the data when employing dynamical two-point correlators (structure factors) for learning. \nContact : pierre.nataf@lpmmc.cnrs.fr
URL:https://sfp-alpes.fr/event/tymoteusz-tula-lpmmc-cnrs-grenoble/
LOCATION:LPMMC – salle Roger Maynard (G421)\, CNRS - LPMMC 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260311T140000
DTEND;TZID=Europe/Paris:20260311T160000
DTSTAMP:20260227T150926Z
CREATED:20260213T091226Z
LAST-MODIFIED:20260227T150926Z
UID:10000064-1773237600-1773244800@sfp-alpes.fr
SUMMARY:Soutenance de Thèse de Subham SENAPATI (IRIG / Spintec)
DESCRIPTION:Spin-orbit torque based magnetic memories evaluation for cryogenic applications\nRésumé : \nThe rapid development of cryogenic computing platforms\, including superconducting electronics\, quantum information processors\, high-performance computing systems\, and space applications\, has created a demand for memory technologies that operate efficiently\, reliably\, and scalable at low temperatures. While magnetic random-access memory (MRAM) is a mature and commercially deployed non-volatile memory at room temperature\, its behaviour and limitations at cryogenic temperatures remain insufficiently explored\, particularly for three-terminal spin-orbit torque magnetic tunnel junctions (SOT-MTJs). This thesis presents a comprehensive experimental and modelling study of SOT-based magnetic memories operated from room temperature (300 K) down to liquid-helium (4 K) temperatures. A dedicated cryogenic characterisation framework is developed to extract magnetic parameters\, quantify switching statistics\, and evaluate write performance under both quasi-static and sub-nanosecond pulsed conditions. Temperature-dependent measurements reveal enhanced magnetic anisotropy and thermal stability at low temperatures\, accompanied by non-trivial trends in critical switching current. By combining experiments with micromagnetic simulations incorporating temperature-dependent material properties and transient Joule heating\, this work demonstrates that self-heating remains a dominant factor during write operations\, especially at cryogenic bath temperatures. Beyond conventional SOT-MRAM\, complementary approaches including optimised spin-transfer torque devices and voltage-gate-assisted SOT switching are investigated. They show that controlling retention via storage layer thickness is a relevant strategy to decrease write current while electric-field control of anisotropy enables efficient modulation of switching across a large temperature range. Overall\, this thesis establishes both the physical limitations and technological potential of SOT- and voltage-gated SOT-based MRAM as viable candidates for future cryogenic memory systems. \nhttps://www.cea.fr/drf/irig/Pages/Animation-scientifique/theses/2026_Senapati.aspx \nContact : admin.spintec@cea.fr
URL:https://sfp-alpes.fr/event/soutenance-de-these-de-subham-senapati-irig-spintec/
LOCATION:CEA – Salle de Séminaire IRIG (1005 – 445)\, Laboratoire Irig/Spintec\, salle de séminaire 445\, bâtiment 1005\, CEA-Grenoble\, Grenoble
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:odile.rossignol@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260312T080000
DTEND;TZID=Europe/Paris:20260312T090000
DTSTAMP:20260130T143016Z
CREATED:20260130T143016Z
LAST-MODIFIED:20260130T143016Z
UID:10000045-1773302400-1773306000@sfp-alpes.fr
SUMMARY:Alban DEROUX (médecine interne\, cytopénies auto-immunes de l'adulte (CERECAI))
DESCRIPTION:Thrombopénie : et si c’était un problème d’anticorps ? Comprendre le PTI \nContact : sante-communication@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/alban-deroux-medecine-interne-cytopenies-auto-immunes-de-ladulte-cerecai/
LOCATION:CHU – Salle Gilbert Faure\, CHU Grenoble Alpes Pavillon Vercors (côté Belledonne)\, La Tronche\, 38043\, France
CATEGORIES:Séminaire
ORGANIZER;CN="CHU Grenoble":MAILTO:sante-communication@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260312T130000
DTEND;TZID=Europe/Paris:20260312T140000
DTSTAMP:20260226T095902Z
CREATED:20260213T093616Z
LAST-MODIFIED:20260226T095902Z
UID:10000066-1773320400-1773324000@sfp-alpes.fr
SUMMARY:Stéphane GUINDON (LIRMM - Montpellier)
DESCRIPTION:Recent advances in phylogeography\nContact : lucie.lamothe@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/stephane-guindon-lirmm-montpellier/
LOCATION:IMAG – Salle de Réunion\, 150 place du Torrent\, St Martin d’Hères\, 38400\, France
CATEGORIES:Séminaire
ORGANIZER;CN="TIMC - IMAG":MAILTO:lucie.lamothe@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260312T183000
DTEND;TZID=Europe/Paris:20260312T223000
DTSTAMP:20260130T153923Z
CREATED:20260130T145238Z
LAST-MODIFIED:20260130T153923Z
UID:10000048-1773340200-1773354600@sfp-alpes.fr
SUMMARY:Hugues Nury (Irig / IBS)
DESCRIPTION:« Soirée du vivant » : récepteurs neuronaux : comment les poisons trouvent leur cible\nCette « S​​oirée du vivant »\, d’un format inédit\, proposera présentation interactive\, quiz participatifs\, échanges libres\, le tout autour de tapas végétales\, pour un moment convivial et grand public.\n​\nHugues Nury\, chercheur CNRS à l’Institut de biologie structurale de Grenoble\, nous plongera dans l’univers fascinant des venins de serpents\, alcaloïdes végétaux et autres insecticides modernes\, qui exercent leurs effets en ciblant des récepteurs neuronaux spécifiques. Il apportera d’abord des connaissances générales pour répondre à des questions essentielles telles : pourquoi certaines substances sont-elles mortelles à des doses infimes tandis que d’autres restent inoffensives ? Comment un récepteur neuronal reconnaît-il son « poison » ?​​​​\n​\n​Il présentera ensuite le projet ANR Pesti Penta qu’il coordonne\, et qui vise à comprendre les mécanismes moléculaires d’action des insecticides sur les récepteurs neuronaux d’insectes. Cette recherche combine biologie structurale\, dynamique moléculaire et électrophysiologie afin d’explorer les interactions entre différentes molécules et leurs cibles biologiques.\nÀ terme\, l’objectif de ces travaux fondamentaux est de contribuer au développement d’insecticides plus efficaces et plus ciblés. \nEn savoir plus : https://www.cea.fr/drf/irig/Pages/Animation-scientifique/seminaires/2026_Nury.aspx
URL:https://sfp-alpes.fr/event/hugues-nury-irig-ibs/
LOCATION:La Casemate\, 2 Place Saint-Laurent\, Grenoble\, 38000\, France
CATEGORIES:Conférence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260313T110000
DTEND;TZID=Europe/Paris:20260313T120000
DTSTAMP:20260227T095425Z
CREATED:20260227T095412Z
LAST-MODIFIED:20260227T095425Z
UID:10000078-1773399600-1773403200@sfp-alpes.fr
SUMMARY:Peter DAHLBERG (Stanford University\, USA)
DESCRIPTION:Fluorescence-guided cryogenic FIB milling and their application to the study of the NLRP3 inflammasome\nRésumé : \nNumerous critical events in cell biology depend on rare ( 1 copy per cell) and small (<500 nm in diameter) structures. Observation of these processes at high resolution using cryogenic electron tomography (CryoET) presents challenges\, as the structures must first be precisely targeted within thin sections through focused ion beam milling. In this presentation\, I will introduce my group’s work on a tri-coincident system that integrates light\, ion\, and electron microscopy at a single focal point. This approach enables real-time monitoring of the milling process and makes two different modes of guidance possible that require no addition of fluorescent fiducials or image registration and whose accuracy far exceeds the optical diffraction limit. I will discuss both guidance modes in detail and then describe their application to the study of the in situ structure of the NLRP3 inflammasome. Despite its central role in innate immunity as a master regulator responsible for proinflammatory cytokine maturation and cell death\, its in situ structure has remained elusive due to challenges in capturing the small singular punctum it forms per cell in thin sections compatible with CryoET — precisely the kind of target the tri-coincident system was developed for. Using our guidance approach\, our cryo-tomograms revealed that the NLRP3 inflammasome forms a dense condensate within and around the microtubule-organizing center. At a later stage after activation\, we saw further growth of the condensate\, and the cells underwent pyroptosis with widespread mitochondrial damage and autophagy. Our study revealed new insights into NLRP3 structure and other organelle alterations during inflammation. \nContact : ibs.seminaires@ibs.fr
URL:https://sfp-alpes.fr/event/peter-dahlberg-stanford-university-usa/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260316T110000
DTEND;TZID=Europe/Paris:20260316T120000
DTSTAMP:20260312T153303Z
CREATED:20260312T153257Z
LAST-MODIFIED:20260312T153303Z
UID:10000100-1773658800-1773662400@sfp-alpes.fr
SUMMARY:Martha MERROW (LMU Munich\, Germany)
DESCRIPTION:A circadian clock in Bacillus subtilis\nRésumé : \nThe circadian clock is a molecular machine that is present in each one of our cells\, directing diverse processes in a cell(developmentally)-specific manner. The natural state of the clock is ‘entrainment’\, namely through synchronization with zeitgeber signals (such as the light/dark cycle) in the environment. Once moved to constant conditions\, a free running rhythm of approximately 24h can be observed\, demonstrating the endogenous nature of the clock. One can understand how the clock relates to our lives by noting the timing of the sleep wake cycle: this is determined by the interaction of the biological (circadian) oscillator and the external zeitgeber cycle. Disrupting the clock in humans and mice leads to increased cancers\, metabolic disease and decreased cognitive performance\, likely through misexpression of key regulators. The circadian clock is an essential aspect of biology and its function can be regarded as a biophysical phenomenon. \nCircadian clocks have been described in all kingdoms of life except for the Eubacteria – until very recently. I will discuss the circadian clock in the model prokaryote\, Bacillus subtilis. We observe rhythms in gene expression\, in colony morphology on agar\, and in metabolism and in planktonic cultures. The circadian transcriptome shows pervasive regulation of gene expression by the biological clock\, even more extensively than sigma factors. The clock is thus a major regulatory phenomenon in this bacterium. Our work begs the questions ‘what is the same as clocks in higher organisms?’ and ‘what is different?’. \nContact : irina.mihalcescu@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/martha-merrow-lmu-munich-germany/
LOCATION:LiPhy\, Salle de Conférence\, 140 rue de la Physique\, St Martin d'Hères\, 38400
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260317T140000
DTEND;TZID=Europe/Paris:20260317T150000
DTSTAMP:20260227T144239Z
CREATED:20260227T144116Z
LAST-MODIFIED:20260227T144239Z
UID:10000085-1773756000-1773759600@sfp-alpes.fr
SUMMARY:Montserrat SOLER-LÓPEZ (Macromolecular X-ray Crystallography\, Imaging and Scattering Group\, ESRF)
DESCRIPTION:Mitochondrial Bioenergetics in Alzheimer’s Disease : Insights from the European Synchrotron\nRésumé : \n\nAlzheimer’s disease (AD) is a devastating neurodegenerative disorder increasingly linked to defects in mitochondrial bioenergetics. At the European Synchrotron Radiation Facility (ESRF)\, we investigate the structural and functional mechanisms that underlie mitochondrial dysfunction in AD\, with a focus on respiratory complex I\, a central player in cellular energy production [1\,2]. \nUsing an integrative biology approach\, we combine macromolecular crystallography\, cryo-electron microscopy\, X-ray imaging\, and spectroscopy to analyse the architecture and regulation of mitochondrial complex I and its assembly factors (MCIA proteins) across spatial and temporal scales. Our structural and functional studies reveal novel regulatory mechanisms of energy metabolism\, including phosphorylation-dependent modulation at the interface of respiration and fatty acid oxidation. Importantly\, we demonstrate that AD-related amyloid oligomers disrupt these regulatory processes within neuronal mitochondria\, thereby contributing to oxidative stress and impaired bioenergetics in AD [3\,4]. Recent synchrotron-based imaging\, including X-ray fluorescence and nano-tomography\, has further provided first insights into the ultrastructure of mitochondrial assemblies in situ. \nCollectively\, these findings highlight how the ESRF’s interdisciplinary\, state-of-the-art methodologies enable breakthroughs in deciphering the molecular basis of neurodegeneration\, offering new perspectives for diagnostic markers and therapeutic strategies targeting mitochondrial dysfunction in Alzheimer’s disease. \n[1] Giachin et al. Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases. Front. Mol. Biosci. 2016\, 3:43 \n[2] McGregor & Soler-Lopez. Structural basis of bioenergetic protein complexes in Alzheimer’s disease pathogenesis. Cur Opin Struct Biol. 2023\, 80:102573 \n[3] Giachin et al. Assembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination. Angew. Chem. Int. Ed. 2021\, 60(9):4689 \n[4] McGregor et al. The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination. Nat Commun. 2023\, 14(1):8248 \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/montserrat-soler-lopez-5macromolecular-x-ray-crystallography-imaging-and-scattering-group-esrf/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260317T140000
DTEND;TZID=Europe/Paris:20260317T150000
DTSTAMP:20260227T085338Z
CREATED:20260227T085330Z
LAST-MODIFIED:20260227T085338Z
UID:10000075-1773756000-1773759600@sfp-alpes.fr
SUMMARY:Klaus MØLMER (Niels Bohr Institute\, University of Copenhagen)
DESCRIPTION:Quantum optics with radiation on the move\nRésumé : \nWith the scaling of quantum technologies to many separate material quantum components\, we may have to couple these systems by propagating quantum radiation\, in the form of light\, microwaves or phonons. There are\, however\, rather fundamental obstacles to the treatment of propagation of quantum radiation and its interaction with matter. These obstacles include the general multimode character of propagating fields and the duration and spatial extent of useful light and microwave pulses. The talk will review a recent theoretical approach to deal theoretically with these obstacles\, and it will present examples of new\, unforeseen\, possibilities for easy preparation and manipulation “on the fly” of quantum states of light and matter. \nCoffee and croissants will be offered after the colloquium in front of the room ! \nPersonne à contacter : Michele Filippone (michele.filippone@cea.fr)
URL:https://sfp-alpes.fr/event/klaus-molmer-niels-bohr-institute-university-of-copenhagen/
LOCATION:CNRS – Salle René Pauthenet (J229)\, CNRS – LNCMI\, 25 avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Séminaire
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