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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260316T110000
DTEND;TZID=Europe/Paris:20260316T120000
DTSTAMP:20260312T153303Z
CREATED:20260312T153257Z
LAST-MODIFIED:20260312T153303Z
UID:10000100-1773658800-1773662400@sfp-alpes.fr
SUMMARY:Martha MERROW (LMU Munich\, Germany)
DESCRIPTION:A circadian clock in Bacillus subtilis\nRésumé : \nThe circadian clock is a molecular machine that is present in each one of our cells\, directing diverse processes in a cell(developmentally)-specific manner. The natural state of the clock is ‘entrainment’\, namely through synchronization with zeitgeber signals (such as the light/dark cycle) in the environment. Once moved to constant conditions\, a free running rhythm of approximately 24h can be observed\, demonstrating the endogenous nature of the clock. One can understand how the clock relates to our lives by noting the timing of the sleep wake cycle: this is determined by the interaction of the biological (circadian) oscillator and the external zeitgeber cycle. Disrupting the clock in humans and mice leads to increased cancers\, metabolic disease and decreased cognitive performance\, likely through misexpression of key regulators. The circadian clock is an essential aspect of biology and its function can be regarded as a biophysical phenomenon. \nCircadian clocks have been described in all kingdoms of life except for the Eubacteria – until very recently. I will discuss the circadian clock in the model prokaryote\, Bacillus subtilis. We observe rhythms in gene expression\, in colony morphology on agar\, and in metabolism and in planktonic cultures. The circadian transcriptome shows pervasive regulation of gene expression by the biological clock\, even more extensively than sigma factors. The clock is thus a major regulatory phenomenon in this bacterium. Our work begs the questions ‘what is the same as clocks in higher organisms?’ and ‘what is different?’. \nContact : irina.mihalcescu@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/martha-merrow-lmu-munich-germany/
LOCATION:LiPhy\, Salle de Conférence\, 140 rue de la Physique\, St Martin d'Hères\, 38400
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260317T140000
DTEND;TZID=Europe/Paris:20260317T150000
DTSTAMP:20260227T144239Z
CREATED:20260227T144116Z
LAST-MODIFIED:20260227T144239Z
UID:10000085-1773756000-1773759600@sfp-alpes.fr
SUMMARY:Montserrat SOLER-LÓPEZ (Macromolecular X-ray Crystallography\, Imaging and Scattering Group\, ESRF)
DESCRIPTION:Mitochondrial Bioenergetics in Alzheimer’s Disease : Insights from the European Synchrotron\nRésumé : \n\nAlzheimer’s disease (AD) is a devastating neurodegenerative disorder increasingly linked to defects in mitochondrial bioenergetics. At the European Synchrotron Radiation Facility (ESRF)\, we investigate the structural and functional mechanisms that underlie mitochondrial dysfunction in AD\, with a focus on respiratory complex I\, a central player in cellular energy production [1\,2]. \nUsing an integrative biology approach\, we combine macromolecular crystallography\, cryo-electron microscopy\, X-ray imaging\, and spectroscopy to analyse the architecture and regulation of mitochondrial complex I and its assembly factors (MCIA proteins) across spatial and temporal scales. Our structural and functional studies reveal novel regulatory mechanisms of energy metabolism\, including phosphorylation-dependent modulation at the interface of respiration and fatty acid oxidation. Importantly\, we demonstrate that AD-related amyloid oligomers disrupt these regulatory processes within neuronal mitochondria\, thereby contributing to oxidative stress and impaired bioenergetics in AD [3\,4]. Recent synchrotron-based imaging\, including X-ray fluorescence and nano-tomography\, has further provided first insights into the ultrastructure of mitochondrial assemblies in situ. \nCollectively\, these findings highlight how the ESRF’s interdisciplinary\, state-of-the-art methodologies enable breakthroughs in deciphering the molecular basis of neurodegeneration\, offering new perspectives for diagnostic markers and therapeutic strategies targeting mitochondrial dysfunction in Alzheimer’s disease. \n[1] Giachin et al. Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases. Front. Mol. Biosci. 2016\, 3:43 \n[2] McGregor & Soler-Lopez. Structural basis of bioenergetic protein complexes in Alzheimer’s disease pathogenesis. Cur Opin Struct Biol. 2023\, 80:102573 \n[3] Giachin et al. Assembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination. Angew. Chem. Int. Ed. 2021\, 60(9):4689 \n[4] McGregor et al. The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination. Nat Commun. 2023\, 14(1):8248 \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/montserrat-soler-lopez-5macromolecular-x-ray-crystallography-imaging-and-scattering-group-esrf/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260317T140000
DTEND;TZID=Europe/Paris:20260317T150000
DTSTAMP:20260227T085338Z
CREATED:20260227T085330Z
LAST-MODIFIED:20260227T085338Z
UID:10000075-1773756000-1773759600@sfp-alpes.fr
SUMMARY:Klaus MØLMER (Niels Bohr Institute\, University of Copenhagen)
DESCRIPTION:Quantum optics with radiation on the move\nRésumé : \nWith the scaling of quantum technologies to many separate material quantum components\, we may have to couple these systems by propagating quantum radiation\, in the form of light\, microwaves or phonons. There are\, however\, rather fundamental obstacles to the treatment of propagation of quantum radiation and its interaction with matter. These obstacles include the general multimode character of propagating fields and the duration and spatial extent of useful light and microwave pulses. The talk will review a recent theoretical approach to deal theoretically with these obstacles\, and it will present examples of new\, unforeseen\, possibilities for easy preparation and manipulation “on the fly” of quantum states of light and matter. \nCoffee and croissants will be offered after the colloquium in front of the room ! \nPersonne à contacter : Michele Filippone (michele.filippone@cea.fr)
URL:https://sfp-alpes.fr/event/klaus-molmer-niels-bohr-institute-university-of-copenhagen/
LOCATION:CNRS – Salle René Pauthenet (J229)\, CNRS – LNCMI\, 25 avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260319T140000
DTEND;TZID=Europe/Paris:20260319T150000
DTSTAMP:20260305T151747Z
CREATED:20260305T151014Z
LAST-MODIFIED:20260305T151747Z
UID:10000094-1773928800-1773932400@sfp-alpes.fr
SUMMARY:Matthieu RAYNAL (Sorbonne Université\, CNRS\, Institut Parisien de Chimie Moléculaire (IPCM))
DESCRIPTION:Supramolecular helical catalysts : chirality induction and beyond\nRésumé : \nHelices are commonly formed by symmetry breaking operating during the bottom-up assembly of small molecules or monomers and their sense of rotation can be controlled by various methods. Important progress has been made in controlling the chiral and structural properties of supramolecular discrete assemblies and polymers.[1] Benzene-1\,3\,5- tricarboxamide[2] (BTA) are ubiquitous synthons for the preparation of hydrogen-bonded helices but it remains to be demonstrated how a given macroscopic property\, notably related to chirality (e.g. chiroptical\, magnetic\, catalytic)\, can be affected by tuning the structure of these supramolecular polymers or copolymers. We demonstrated that the supramolecular chirality of BTA assemblies can be transferred to intrinsically achiral metal centres (Rh\, Cu) located at their periphery.[3] How the selectivity of a catalytic reaction of reference can be affected by the nature of the monomers\, the presence of metal centres\, and the addition of achiral additives will be particularly discussed.[4] Not only a fine tuning of the chirality of the supramolecular assemblies but also a proper control of their dynamicity is key to address important challenges. We recently disclose the possibility to select one major (70%-79%) amongst four possible stereoisomers of an amino alcohol by applying the supramolecular helical catalyst in either concomitant (with no inversion of catalyst handedness) or sequential (with inversion of catalyst handedness) hydrosilylation and hydroamination reactions [5]. \nReferences : \n[1] Yashima E. et al. Chem. Rev.\, 2016\, 116\, 13752.\n[2] Cantekin S. et al. Chem. Soc. Rev.\, 2012\, 41\, 6125.\n[3] Desmarchelier A. et al. J. Am. Chem. Soc.\, 2016\, 138\, 4908.\n[4] (a) Li Y. et al. J. Am. Chem Soc.\, 2020\, 142\, 5676. (b) Martínez-Aguirre M. A. et al. Angew. Chem. Int. Ed.\, 2021\, 60\, 4183. (c) Hammoud A. et al. Chem. Eur. J.\, 2023\, e202300189. (d) Kong H. et al. ChemistryEurope\, 2023\, 1\, e202300027.\n[5] Chen\, R. et al. Nature Commun.\, 2024\, 15\, 4116 \n_ \nContact : adrien.quintard@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/matthieu-raynal-sorbonne-universite-cnrs-institut-parisien-de-chimie-moleculaire-ipcm/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260319T140000
DTEND;TZID=Europe/Paris:20260319T150000
DTSTAMP:20260227T145253Z
CREATED:20260227T145207Z
LAST-MODIFIED:20260227T145253Z
UID:10000086-1773928800-1773932400@sfp-alpes.fr
SUMMARY:Rebeca RIBEIRO (C2N\, Paris-Saclay)
DESCRIPTION:Twist-Angle-Controlled Anomalous Gating in Bilayer Graphene/BN Heterostructures\nRésumé : \nAnomalous gating effects—such as gate ineffectiveness and pronounced hysteresis—have been observed in graphene-based systems encapsulated in boron nitride (BN) and linked to a possible ferroelectric state. However\, their origin\, stability\, and reproducibility remain under debate. During this talk\, I will present charge transport experiments in dual-gated\, dynamically rotatable van der Waals heterostructures based on bilayer graphene encapsulated in BN. Remarkably\, the angular degree of freedom acts as an ON/OFF switch for the anomalous gating response. We show that the angular alignment between the two BN layers is the key parameter governing these effects. Both gate ineffectiveness and hysteresis are highly sensitive to small angular changes\, and they clearly change in behavior\, which we classify into three distinct regimes. \nContact : florence.levy-bertrand@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/rebeca-ribeiro-c2n-paris-saclay/
LOCATION:CNRS – Salle Rémy Lemaire (K223)\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
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