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TZID:Europe/Paris
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260315T000000
DTEND;TZID=Europe/Paris:20260320T235959
DTSTAMP:20260124T041542Z
CREATED:20260124T041542Z
LAST-MODIFIED:20260124T041542Z
UID:10000033-1773532800-1774051199@sfp-alpes.fr
SUMMARY:Grenoble Neurotech School 2026
DESCRIPTION:Plus d’informations : https://neurotech2026.sciencesconf.org/?lang=en \n  \nContact : salma.mezzi@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/grenoble-neurotech-school-2026/
LOCATION:Centre Paul Langevin\, Aussois\, France
CATEGORIES:Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260316T110000
DTEND;TZID=Europe/Paris:20260316T120000
DTSTAMP:20260312T153303Z
CREATED:20260312T153257Z
LAST-MODIFIED:20260312T153303Z
UID:10000100-1773658800-1773662400@sfp-alpes.fr
SUMMARY:Martha MERROW (LMU Munich\, Germany)
DESCRIPTION:A circadian clock in Bacillus subtilis\nRésumé : \nThe circadian clock is a molecular machine that is present in each one of our cells\, directing diverse processes in a cell(developmentally)-specific manner. The natural state of the clock is ‘entrainment’\, namely through synchronization with zeitgeber signals (such as the light/dark cycle) in the environment. Once moved to constant conditions\, a free running rhythm of approximately 24h can be observed\, demonstrating the endogenous nature of the clock. One can understand how the clock relates to our lives by noting the timing of the sleep wake cycle: this is determined by the interaction of the biological (circadian) oscillator and the external zeitgeber cycle. Disrupting the clock in humans and mice leads to increased cancers\, metabolic disease and decreased cognitive performance\, likely through misexpression of key regulators. The circadian clock is an essential aspect of biology and its function can be regarded as a biophysical phenomenon. \nCircadian clocks have been described in all kingdoms of life except for the Eubacteria – until very recently. I will discuss the circadian clock in the model prokaryote\, Bacillus subtilis. We observe rhythms in gene expression\, in colony morphology on agar\, and in metabolism and in planktonic cultures. The circadian transcriptome shows pervasive regulation of gene expression by the biological clock\, even more extensively than sigma factors. The clock is thus a major regulatory phenomenon in this bacterium. Our work begs the questions ‘what is the same as clocks in higher organisms?’ and ‘what is different?’. \nContact : irina.mihalcescu@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/martha-merrow-lmu-munich-germany/
LOCATION:LiPhy\, Salle de Conférence\, 140 rue de la Physique\, St Martin d'Hères\, 38400
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260317T140000
DTEND;TZID=Europe/Paris:20260317T150000
DTSTAMP:20260227T144239Z
CREATED:20260227T144116Z
LAST-MODIFIED:20260227T144239Z
UID:10000085-1773756000-1773759600@sfp-alpes.fr
SUMMARY:Montserrat SOLER-LÓPEZ (Macromolecular X-ray Crystallography\, Imaging and Scattering Group\, ESRF)
DESCRIPTION:Mitochondrial Bioenergetics in Alzheimer’s Disease : Insights from the European Synchrotron\nRésumé : \n\nAlzheimer’s disease (AD) is a devastating neurodegenerative disorder increasingly linked to defects in mitochondrial bioenergetics. At the European Synchrotron Radiation Facility (ESRF)\, we investigate the structural and functional mechanisms that underlie mitochondrial dysfunction in AD\, with a focus on respiratory complex I\, a central player in cellular energy production [1\,2]. \nUsing an integrative biology approach\, we combine macromolecular crystallography\, cryo-electron microscopy\, X-ray imaging\, and spectroscopy to analyse the architecture and regulation of mitochondrial complex I and its assembly factors (MCIA proteins) across spatial and temporal scales. Our structural and functional studies reveal novel regulatory mechanisms of energy metabolism\, including phosphorylation-dependent modulation at the interface of respiration and fatty acid oxidation. Importantly\, we demonstrate that AD-related amyloid oligomers disrupt these regulatory processes within neuronal mitochondria\, thereby contributing to oxidative stress and impaired bioenergetics in AD [3\,4]. Recent synchrotron-based imaging\, including X-ray fluorescence and nano-tomography\, has further provided first insights into the ultrastructure of mitochondrial assemblies in situ. \nCollectively\, these findings highlight how the ESRF’s interdisciplinary\, state-of-the-art methodologies enable breakthroughs in deciphering the molecular basis of neurodegeneration\, offering new perspectives for diagnostic markers and therapeutic strategies targeting mitochondrial dysfunction in Alzheimer’s disease. \n[1] Giachin et al. Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases. Front. Mol. Biosci. 2016\, 3:43 \n[2] McGregor & Soler-Lopez. Structural basis of bioenergetic protein complexes in Alzheimer’s disease pathogenesis. Cur Opin Struct Biol. 2023\, 80:102573 \n[3] Giachin et al. Assembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination. Angew. Chem. Int. Ed. 2021\, 60(9):4689 \n[4] McGregor et al. The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination. Nat Commun. 2023\, 14(1):8248 \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/montserrat-soler-lopez-5macromolecular-x-ray-crystallography-imaging-and-scattering-group-esrf/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260317T140000
DTEND;TZID=Europe/Paris:20260317T150000
DTSTAMP:20260227T085338Z
CREATED:20260227T085330Z
LAST-MODIFIED:20260227T085338Z
UID:10000075-1773756000-1773759600@sfp-alpes.fr
SUMMARY:Klaus MØLMER (Niels Bohr Institute\, University of Copenhagen)
DESCRIPTION:Quantum optics with radiation on the move\nRésumé : \nWith the scaling of quantum technologies to many separate material quantum components\, we may have to couple these systems by propagating quantum radiation\, in the form of light\, microwaves or phonons. There are\, however\, rather fundamental obstacles to the treatment of propagation of quantum radiation and its interaction with matter. These obstacles include the general multimode character of propagating fields and the duration and spatial extent of useful light and microwave pulses. The talk will review a recent theoretical approach to deal theoretically with these obstacles\, and it will present examples of new\, unforeseen\, possibilities for easy preparation and manipulation “on the fly” of quantum states of light and matter. \nCoffee and croissants will be offered after the colloquium in front of the room ! \nPersonne à contacter : Michele Filippone (michele.filippone@cea.fr)
URL:https://sfp-alpes.fr/event/klaus-molmer-niels-bohr-institute-university-of-copenhagen/
LOCATION:CNRS – Salle René Pauthenet (J229)\, CNRS – LNCMI\, 25 avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260319T140000
DTEND;TZID=Europe/Paris:20260319T150000
DTSTAMP:20260305T151747Z
CREATED:20260305T151014Z
LAST-MODIFIED:20260305T151747Z
UID:10000094-1773928800-1773932400@sfp-alpes.fr
SUMMARY:Matthieu RAYNAL (Sorbonne Université\, CNRS\, Institut Parisien de Chimie Moléculaire (IPCM))
DESCRIPTION:Supramolecular helical catalysts : chirality induction and beyond\nRésumé : \nHelices are commonly formed by symmetry breaking operating during the bottom-up assembly of small molecules or monomers and their sense of rotation can be controlled by various methods. Important progress has been made in controlling the chiral and structural properties of supramolecular discrete assemblies and polymers.[1] Benzene-1\,3\,5- tricarboxamide[2] (BTA) are ubiquitous synthons for the preparation of hydrogen-bonded helices but it remains to be demonstrated how a given macroscopic property\, notably related to chirality (e.g. chiroptical\, magnetic\, catalytic)\, can be affected by tuning the structure of these supramolecular polymers or copolymers. We demonstrated that the supramolecular chirality of BTA assemblies can be transferred to intrinsically achiral metal centres (Rh\, Cu) located at their periphery.[3] How the selectivity of a catalytic reaction of reference can be affected by the nature of the monomers\, the presence of metal centres\, and the addition of achiral additives will be particularly discussed.[4] Not only a fine tuning of the chirality of the supramolecular assemblies but also a proper control of their dynamicity is key to address important challenges. We recently disclose the possibility to select one major (70%-79%) amongst four possible stereoisomers of an amino alcohol by applying the supramolecular helical catalyst in either concomitant (with no inversion of catalyst handedness) or sequential (with inversion of catalyst handedness) hydrosilylation and hydroamination reactions [5]. \nReferences : \n[1] Yashima E. et al. Chem. Rev.\, 2016\, 116\, 13752.\n[2] Cantekin S. et al. Chem. Soc. Rev.\, 2012\, 41\, 6125.\n[3] Desmarchelier A. et al. J. Am. Chem. Soc.\, 2016\, 138\, 4908.\n[4] (a) Li Y. et al. J. Am. Chem Soc.\, 2020\, 142\, 5676. (b) Martínez-Aguirre M. A. et al. Angew. Chem. Int. Ed.\, 2021\, 60\, 4183. (c) Hammoud A. et al. Chem. Eur. J.\, 2023\, e202300189. (d) Kong H. et al. ChemistryEurope\, 2023\, 1\, e202300027.\n[5] Chen\, R. et al. Nature Commun.\, 2024\, 15\, 4116 \n_ \nContact : adrien.quintard@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/matthieu-raynal-sorbonne-universite-cnrs-institut-parisien-de-chimie-moleculaire-ipcm/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260319T140000
DTEND;TZID=Europe/Paris:20260319T150000
DTSTAMP:20260227T145253Z
CREATED:20260227T145207Z
LAST-MODIFIED:20260227T145253Z
UID:10000086-1773928800-1773932400@sfp-alpes.fr
SUMMARY:Rebeca RIBEIRO (C2N\, Paris-Saclay)
DESCRIPTION:Twist-Angle-Controlled Anomalous Gating in Bilayer Graphene/BN Heterostructures\nRésumé : \nAnomalous gating effects—such as gate ineffectiveness and pronounced hysteresis—have been observed in graphene-based systems encapsulated in boron nitride (BN) and linked to a possible ferroelectric state. However\, their origin\, stability\, and reproducibility remain under debate. During this talk\, I will present charge transport experiments in dual-gated\, dynamically rotatable van der Waals heterostructures based on bilayer graphene encapsulated in BN. Remarkably\, the angular degree of freedom acts as an ON/OFF switch for the anomalous gating response. We show that the angular alignment between the two BN layers is the key parameter governing these effects. Both gate ineffectiveness and hysteresis are highly sensitive to small angular changes\, and they clearly change in behavior\, which we classify into three distinct regimes. \nContact : florence.levy-bertrand@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/rebeca-ribeiro-c2n-paris-saclay/
LOCATION:CNRS – Salle Rémy Lemaire (K223)\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260320T110000
DTEND;TZID=Europe/Paris:20260320T120000
DTSTAMP:20260313T171306Z
CREATED:20260227T100104Z
LAST-MODIFIED:20260313T171306Z
UID:10000079-1774004400-1774008000@sfp-alpes.fr
SUMMARY:Chrystel GENOUD (EPFL\, Lausane\, Suisse)
DESCRIPTION:Understanding tissue by volumeEM – some examples from an EM platform\nSéminaire dans le cadre de la Journée Microscopie Electronique \nRésumé : \nUnderstanding the complex architecture of cells and tissues requires imaging technologies that can bridge the gap between ultrastructural details and large-volume context in room temperature and cryo-EM. Volume electron microscopy (volume EM) addresses this need by enabling 3D imaging of biological samples at nanometer resolution over tens to hundreds of microns. In this presentation\, I will provide an overview of volume EM techniques available on our platform based on examples and how we combine it with correlative light and electron microscopy.I will also show how we are adressing the targeting of small structures in lare tissue in cryo-ET by using the serial lift-out method and cryo-CLEM. The example of targeting the Casparian strip in the root of Arabidopsis thaliana will be developed. \nContact : ibs.seminaires@ibs
URL:https://sfp-alpes.fr/event/chrystel-genoud-epfl-lausane-suisse/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260320T123000
DTEND;TZID=Europe/Paris:20260320T131500
DTSTAMP:20260227T153942Z
CREATED:20260213T092546Z
LAST-MODIFIED:20260227T153942Z
UID:10000065-1774009800-1774012500@sfp-alpes.fr
SUMMARY:Pascal BOUSSEMART (Expert IA Générative (Orange Recherche Grenoble))
DESCRIPTION:L’IA au coeur du travail\nRésumé : \nOn parle beaucoup d’intelligence artificielle dans l’entreprise. Trop souvent comme d’un outil. Parfois comme d’une menace. Rarement comme d’un déplacement profond du rôle de l’employé\, du manager et de l’organisation elle‑même. \nÀ partir d’exemples concrets vécus (interaction réelle avec une IA\, arbitrages humains\, conflits de sens\, décisions managériales)\, la conférence explore : l’impact de l’IA sur le métier\, l’autonomie\, la responsabilité et la reconnaissance et aussi comment l’entreprise doit se reconfigurer. \nIl ne s’agit pas de dire si l’IA est « bonne » ou « mauvaise ». Il s’agit de comprendre ce que devient l’employé quand penser\, décider\, écrire\, analyser ne lui appartiennent plus totalement.  \nUne conférence pour dirigeants\, managers\, chercheurs et salariés qui refusent les discours simplistes\, et veulent explorer ce choc discret mais radical qui est en cours dans le monde du travail. \nÀ propos des intervenants : \nPascal BOUSSEMART est expert en Intelligence Artificielle Générative et Formateur en Prompt Engineering chez Orange Recherche Grenoble. \nIngénieur diplômé Mines-Telecom\, il cumule plus de 30 ans d’expérience dans l’innovation technologique. Véritable pionnier de l’IA générative\, Pascal est l’auteur de plusieurs brevets dans ce domaine très innovant et il a participé au dépôt des projets coopératifs de recherche européens dont le dernier en 2025 sur l’impact des IA en entreprise. Il est également le créateur et animateur du\n« Papotage IA Gen » chez Orange\, un espace hebdomadaire dédié au partage et à la veille sur les usages de ces technologies. \nContact : giant.campus@cea.fr
URL:https://sfp-alpes.fr/event/pascal-boussemart-expert-ia-generative-orange-recherche-grenoble/
LOCATION:Amphi Minatec\, 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="GIANT":MAILTO:giant.campus@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260320T133000
DTEND;TZID=Europe/Paris:20260320T143000
DTSTAMP:20260305T154053Z
CREATED:20260226T162747Z
LAST-MODIFIED:20260305T154053Z
UID:10000073-1774013400-1774017000@sfp-alpes.fr
SUMMARY:ATTENTION !!! Séminaire reporté. Initialement prévu le 30 mars  !!! - Bjoern WEHINGER (ESRF)
DESCRIPTION:Neutron and x-rays scattering on quantum magnets at high pressures and low temperatures\nRésumé : \nApplication of external pressure acts as clean tuning parameter of inter-atomic distances and bond angles and therefor allows for precise control of magnetic interactions in condensed matter. Extreme conditions can thus be used to stabilize novel quantum phases and drive systems close to quantum criticality where new and exciting phenomena are expected. Within this seminar I will show how recent advances in neutron and x-ray scattering allows to access fingerprints of quantum correlations and present novel results on quantum magnets at the extreme. \n_ \nArno Hiezz (College 4 Secretary) \nExternal visitors may ask for a site access to tellier(at)ill.fr \n 
URL:https://sfp-alpes.fr/event/bjoern-wehinger-esrf/
LOCATION:ILL – Salle de Séminaire (110-111)\, ILL 50 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260323T110000
DTEND;TZID=Europe/Paris:20260323T120000
DTSTAMP:20260320T094546Z
CREATED:20260320T094540Z
LAST-MODIFIED:20260320T094546Z
UID:10000101-1774263600-1774267200@sfp-alpes.fr
SUMMARY:Chloé ROFFAY (IMP Vienna\, Austria)
DESCRIPTION:Uncovering the forces driving the fate and shape of the extraembryonic amnion during human gastrulation\nRésumé : \nExtraembryonic tissues provide key molecular signals and mechanical support to the growing embryo. For instance\, the extraembryonic amnion\, which forms a fluid-filled sac surrounding the embryo\, was recently shown to trigger germ layer specification during gastrulation\, by secreting BMP ligands. Despite the key roles of extraembryonic tissues in embryo development\, little is still known regarding their molecular and biophysical programs\, particularly in human. Using a 2D stem cell-based model of human gastrulation\, termed gastruloid discs\, we found that amnion cells undergo a sharp columnar-to-squamous transition concomitantly with fate specification. Via biophysical modelling\, direct force measurements\, pharmacological and genetic perturbations\, we showed that this morphogenetic transition is amnion-intrinsic and it is driven by active wetting\, i.e. a transition from tensile to adhesion-dominated cellular states. Molecularly\, active wetting is implemented via a rewiring of cytoskeleton composition\, from actomyosin to keratin-based cytoskeletal networks\, akin to a bistable toggle-switch in gene regulatory networks. Strikingly\, blocking shape changes at the colony edge results both in defective cellular states in the amnion and impaired gastruloid disc morphogenesis within the embryonic compartment. Together\, our findings establish that a cytoskeletal toggle switch couples fate specification to tissue architecture in the human amnion and suggest an unexpectedly active mechanical role for extraembryonic tissues in shaping the embryo proper. \nContact : thomas.boudou@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/chloe-roffay-imp-vienna-austria/
LOCATION:LiPhy – Salle de conférence\, LiPhy 140 avenue de la Physique\, St Martin d'Hères\, 38402\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260323T140000
DTEND;TZID=Europe/Paris:20260323T150000
DTSTAMP:20260306T162442Z
CREATED:20260306T161739Z
LAST-MODIFIED:20260306T162442Z
UID:10000098-1774274400-1774278000@sfp-alpes.fr
SUMMARY:Stéphanie ROCCIA (LPSC-CNRS/UGA\, GRENOBLE)
DESCRIPTION:The search for neutron electric dipole moment at PSI\nRésumé : \nThe Universe and its history are simultaneously very well understood and still a big mystery. We have amazing tools from satellites to\nobservatories to weight the universe over its history. But the components of the Universe can simply not yet be explained by physicists. To get the full picture\, we need to identify and understand the interactions at play throughout the life of the Universe. This is the meeting point between particle physics and cosmology. At this meeting point stands the neutron\, a common particle that we can uniquely use in high precision experiments.\nI will present how experiments searching for a permanent electric dipole moment of the neutron (nEDM) aim at discovering new sources of CP violation beyond the Standard Model of particle physics and understanding the origin of the matter-antimatter asymmetry of the Universe. The quest for the neutron electric dipole moment started more than sixty years ago. In recent experiments\, polarized ultra-cold neutrons are stored in material bottles.\nI will present the ongoing efforts at the Paul Scherrer Institute in Switzerland where the n2EDM spectrometer has taken the first “physics data” in 2025. A large fraction of this dataset is dedicated to measurements of the UCN spectrum. I will present the newest UCN spectroscopy techniques that were recently published and the reasons for the importance of a deep understanding of the UCN spectrum. \n— \nHanno Filter (College 3 Secretary) \nExternal visitors may ask for a site access to tellier(at)ill.fr \nZoom link : https://ill.zoom.us/j/98964195699?pwd=vPhNT17CAeoDUr7QX4PjfyPnWsHuMU.1 – Password : SeminarC3
URL:https://sfp-alpes.fr/event/stephanie-roccia-lpsc-cnrs-uga-grenoble-2/
LOCATION:ILL – Salle de Séminaire (110-111)\, ILL 50 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260326T130000
DTEND;TZID=Europe/Paris:20260326T140000
DTSTAMP:20260313T094659Z
CREATED:20260213T094059Z
LAST-MODIFIED:20260313T094659Z
UID:10000067-1774530000-1774533600@sfp-alpes.fr
SUMMARY:Martial MARBOUTY (Institut Pasteur – Paris)
DESCRIPTION:Phages with a broad host range are common across ecosystems\nContact : lucie.lamothe@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/martial-marbouty-institut-pasteur-paris/
LOCATION:IMAG – Salle de Réunion\, 150 place du Torrent\, St Martin d’Hères\, 38400\, France
CATEGORIES:Séminaire
ORGANIZER;CN="TIMC - IMAG":MAILTO:lucie.lamothe@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260327T110000
DTEND;TZID=Europe/Paris:20260327T120000
DTSTAMP:20260320T095209Z
CREATED:20260320T095205Z
LAST-MODIFIED:20260320T095209Z
UID:10000102-1774609200-1774612800@sfp-alpes.fr
SUMMARY:Jacopo DE NARDIS (Cergy Paris University)
DESCRIPTION:Anticoncentration of Wave Functions and Information-Protected Phases in Noisy Quantum Chaotic Systems\nRésumé : \nI will present recent results on noisy quantum chaotic dynamics\, with a particular focus on wave-function anticoncentration—characterized\, for instance\, through bitstrings output distributions—and on Information-protected phases that persist at finite circuit depth. \nContact : serge.florens@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/jacopo-de-nardis-cergy-paris-university/
LOCATION:LPMMC – salle Roger Maynard (G421)\, CNRS - LPMMC 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260330T090000
DTEND;TZID=Europe/Paris:20260330T110000
DTSTAMP:20260227T151057Z
CREATED:20260227T100731Z
LAST-MODIFIED:20260227T151057Z
UID:10000080-1774861200-1774868400@sfp-alpes.fr
SUMMARY:Soutenance de Thèse de Mohammad CHORFA (IBS/Groupe Synchrotron)
DESCRIPTION:Effets de la dynamique structurale d’une famille de protéines fluorescentes infrarouges sur leurs propriétés de fluorescence\nRésumé : \nCe travail de thèse consiste en une étude structurale approfondie d’une famille de protéines fluorescentes infrarouges (IFP) développées à partir du bactérophytochrome d’une bactérie Gram-négative du genre Bradyrhizobium\, constituée de la protéine mIFP et de ses variants décalés vers le bleu iBlueberry et iBlueberry2. Les IFP présentent un fort intérêt en imagerie de corps entier en raison de l’existence d’une fenêtre optique des tissus entre 650 et 900 nm\, au-dessus du domaine de longueur d’onde dans lequel l’hémoglobine et la déoxi-hémoglobine absorbent\, et en-dessous du domaine dans lequel l’eau et les lipides absorbent et diffusent la lumière. Les protéines étudiées ici présentent un pic d’émission de fluorescence entre 660 et 720 nm. \nLe bactériophytochrome et les IFP qui en sont dérivées utilisent la biliverdine\, un produit du catabolisme des hèmes\, comme chromophore afin d’absorber la lumière entre 640 et 690 nm. L’étude structurale a permis de montrer qu’une boucle localisée au voisinage de la biliverdine pouvait aborder un grand nombre de conformations\, à la différence des autres phytochromes et IFP étudiés jusqu’à présent\, où cette boucle ne semble posséder qu’une seule conformation. La conséquence de cette fluctuation conformationnelle est la présence d’une configuration du chromophore jamais encore observée menant à une conformation compacte du macrocycle formé par les quatre cycles pyrroles de la biliverdine\, distincte de la conformation linéaire\, ou étendue\, habituellement observée. Les spectroscopies d’absorption UV-Visible et d’émissions de fluorescence in crystallo\, c’est-à-dire directement appliquées aux cristaux\, ont permis de montrer que la conformation compacte du chromophore menait à un pic d’émission de fluorescence au-delà de 760 nm pour iBlueberry et iBlueberry 2\, et de 800 nm pour mIFP. Cette conformation semble être favorisé par l’empilement cristallin\, et être seulement très faiblement peuplée en solution. \nL’analyse des séquences de bactériophytochromes et d’IFP a permis de mettre en évidence la conformation particulière du coude beta au début de la boucle en question. L’ingénierie de ce coude beta chez un membre d’une autre famille de protéines fluorescentes a montré qu’elle permettait effectivement d’augmenter la plasticité de la boucle. \nCe travail donne des pistes pour modifier la configuration du chromophore au sein de la protéine par ingénierie rationnelle\, notamment en utilisant des méthodes basées sur l’intelligence artificielle\, et ainsi permettre d’obtenir de nouvelles IFPs avec des maxima d’émission en plein milieu de la fenêtre optique des tissus\, afin de mieux utiliser celle-ci dans des expériences de marquage à plusieurs couleurs en imagerie tissulaire ou de corps entier. \nContact :ibs.seminaires@ibs.fr
URL:https://sfp-alpes.fr/event/soutenance-de-these-de-mohammad-chorfa-ibs-groupe-synchrotron/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
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DTSTART;TZID=Europe/Paris:20260330T140000
DTEND;TZID=Europe/Paris:20260330T150000
DTSTAMP:20260312T152502Z
CREATED:20260312T152112Z
LAST-MODIFIED:20260312T152502Z
UID:10000099-1774879200-1774882800@sfp-alpes.fr
SUMMARY:Sander VAN SMAALEN (Laboratory of Crystallography\, Bayerisches Geoinstitut\, University of Bayreuth)
DESCRIPTION:Chiral charge density waves in EuAl4 and related compounds\nRésumé : \nThe BaAl 4 structure type has centrosymmetric\, tetragonal symmetry\, I4/mmm\, with three crystallographically independent atom sites: Ba\, Al1 and Al2. Solid solution series RAl 4-x Gax (R= Eu\, Sr\, Ca\, Ba; 0 < x < 4) crystallize in this structure type [1]\, where Ga preferably occupies the Al2 site. Accordingly\, complete chemical order is found for x = 0\, 2\, 4. Incommensurate charge-density waves (CDWs) have been observed in several of these ordered compounds. For the other values of x\, lack of chemical order leads to suppression of the CDW transition. At much lower temperatures (T = 10–30 K) magnetic order appears for the compounds with magnetic Eu atoms. Here\, we present the crystal structures of the incommensurate CDWs of EuAl 4 \, EuAl 2 Ga2 and SrAl 4 . In particular\, the symmetry of the CDWs is analyzed in view of x-ray diffraction data (present data [2–5])\, and results of transmission electron microscopy (TEM)\, density functional theory (DFT) calculations and inelastic x ray scattering (IXS) from the literature [6–8].\nReferences : \n[1] M. Stavinoha et al.\, Phys. Rev. B 97\, 195146 (2018). Charge density wave behavior and order-disorder in the antiferromagnetic metallic series Eu(Ga1-x Al x )4 .\n[2] S. Ramakrishnan et al.\, IUCrJ 9\, 378–385 (2022). Orthorhombic charge density wave on the tetragonal lattice of EuAl 4 .\n[3] S. R. Kotla et al.\, Phys. Rev. B 112\, 064113 (2025). Broken inversion symmetry in the charge density wave phase in EuAl 4 .\n[4] S. Ramakrishnan et al.\, Phys. Rev. Research 6\, 023277 (2024). Non-centrosymmetric\, transverse structural modulation in SrAl 4 \, and elucidation of its origin in the BaAl 4 family of\ncompounds.\n[5] H. Agarwal et al.\, Phys. Rev. B 111\, 155144 (2025). I-centered versus F-centered orthorhombic symmetry and negative thermal expansion of the charge density wave of EuAl2 Ga2 .\n[6] H. Ni et al.\, Phys. Rev. Mater. 8\, 104414 (2024). Real-space visualization of atomic displacements in a long-wavelength charge density wave using cryogenic 4D-STEM.\n[7] A. N. Korshunov et al.\, Phys. Rev. B 110\, 045102 (2024). Phonon softening and atomic modulations in EuAl 4 .\n[8] F. Z. Yang et al.\, Nature Commun. 16\, 10401 (2025). Incommensurate Transverse Peierls Transition and Signature of Chiral Charge Density Wave in EuAl4 \nContact : andrew.fefferman@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/sander-van-smaalen-laboratory-of-crystallography-bayerisches-geoinstitut-university-of-bayreuth/
LOCATION:CNRS – Salle Louis Weil (E424)\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
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DTSTART;TZID=Europe/Paris:20260331T140000
DTEND;TZID=Europe/Paris:20260331T150000
DTSTAMP:20260227T152234Z
CREATED:20260227T152048Z
LAST-MODIFIED:20260227T152234Z
UID:10000088-1774965600-1774969200@sfp-alpes.fr
SUMMARY:Simon PONTON (chargé de recherche CNRS - SIMaP)
DESCRIPTION:Development of the combinatorial approach for the CVD thin film deposition process : Multiphysics coupling and machine learning\nRésumé : \nThe combinatorial approach applied to chemical vapor deposition processes integrating high-throughput experiments\, computational simulations\, and machine learning seems to emerge as a transformative paradigm to accelerate the discovery of novel materials. Through systematic gradient explorations\, large-scale datasets can be generated to deepen our understanding of process-structure-property relationships. Machine learning models\, trained on experimental and simulated data enable rapid prediction and identification of high-potential solutions\, thereby guiding future experiments and simulations. The synergy not only reduces the time or cost associated with material discovery but also unlocks access to previously unexplored regions of the materials space. \nShort Bio/CVMy academic journey began in Grenoble\, where I studied chemistry before developing a keen interest in materials sciences\, particularly nanostructures and their processing. Driven by a desire to unravel the underlying mechanisms\, I started my PhD in Toulouse\, between the CIRIMAT and LGC. There\, I expanded my expertise in chemical engineering and Multiphysics simulation. After nearly two years of postdoctoral research\, I sought to broaden my research perspective and joined Polytechnique Montréal in the chemical engineering section for two postdoctoral positions that led to an associate professor role. However\, my longing for French cheese proved irresistible\, I successfully secured a position at CNRS and joined SIMaP in February 2026. \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/simon-ponton-charge-de-recherche-cnrs-simap/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
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DTSTART;TZID=Europe/Paris:20260331T140000
DTEND;TZID=Europe/Paris:20260331T160000
DTSTAMP:20260227T151214Z
CREATED:20260227T101524Z
LAST-MODIFIED:20260227T151214Z
UID:10000082-1774965600-1774972800@sfp-alpes.fr
SUMMARY:Soutenance de Thèse de Espérance AHO (IBS/Groupe Structure et Activité des Glycosaminoglycanes)
DESCRIPTION:Structural and Functional effect of CXCL12/Heparan Sulfate Interactions at the Cell Surface\nRésumé : \nThe glycocalyx is a protective layer covering the surface of cells\, particularly endothelial cells\, and represents a major regulator of cell-environment interactions. It functions as a mechanical barrier\, a mechanosensor\, and a signalling platform that controls vascular permeability. In inflammatory and tumor contexts\, alterations in glycocalyx structure and density promote increased cell adhesion\, extravasation\, and metastatic dissemination. Structurally\, the glycocalyx is composed of glycolipids\, glycoproteins and proteoglycans bearing glycosaminoglycan (GAG) chains\, including heparan sulfate (HS). These linear polysaccharides\, organized into sulfated and non-sulfated domains\, interact with numerous proteins\, including growth factors and chemokines\, thereby modulating their bioavailability and biological activity. Notably\, chemokine-HS interactions are essential for the formation of chemotactic gradients involved in leukocyte recruitment\, inflammatory extravasation\, and tumor progression. The chemokine CXCL12 (stromal cell-derived factor-1\, SDF-1)\, a member of the CXC chemokine family\, exists as six distinct isoforms generated by alternative splicing of the CXCL12 gene. These isoforms share a common N-terminal sequence but differ in their C-terminal extensions\, which influence their interactions with HS. Among them\, CXCL12γ isoform\, characterized by its exceptionally high affinity for HS\, represent a particularly relevant candidate. \nThis work builds upon previous findings from our group showing\, using biophysical approaches (QCM-D\, FRAP)\, that CXCL12 is able to induce cross-linking of HS chains on biomimetic surfaces\, resulting in HS rigidification\, decreased layer thickness\, and reduced HS lateral mobility. These observations suggest that chemokine-HS interactions can modify the physical properties of HS beyond a simple ligand-presentation role. The central hypothesis of this project is that binding of the CXCL12γ to HS induces remodelling of the endothelial glycocalyx at the cell surface thereby changing cellular mechanical properties and promoting immune cell adhesion. Here\, we investigate the impact of CXCL12γ on HS organization across molecular\, nanoscale\, and cellular levels by combining biomimetic surfaces\, biophysical approaches\, super-resolution microscopy\, and cell-based assays. \nWe show that CXCL12γ reorganizes HS chains at the endothelial cell surface and that all HS-binding sites are required for efficient HS rigidification and network reorganization. CXCL12γ-driven remodeling of the glycocalyx reduces HS thickness and alters its nanoscale topology\, thereby promoting paracellular permeability and formation of adhesive platforms that facilitate leukocyte capture\, and firm adhesion. \nContact : ibs.seminaires@ibs
URL:https://sfp-alpes.fr/event/esperance-aho-ibs-groupe-structure-et-activite-des-glycosaminoglycanes/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
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