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DTSTART;TZID=Europe/Paris:20260317T140000
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DTSTAMP:20260227T085338Z
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SUMMARY:Klaus MØLMER (Niels Bohr Institute\, University of Copenhagen)
DESCRIPTION:Quantum optics with radiation on the move\nRésumé : \nWith the scaling of quantum technologies to many separate material quantum components\, we may have to couple these systems by propagating quantum radiation\, in the form of light\, microwaves or phonons. There are\, however\, rather fundamental obstacles to the treatment of propagation of quantum radiation and its interaction with matter. These obstacles include the general multimode character of propagating fields and the duration and spatial extent of useful light and microwave pulses. The talk will review a recent theoretical approach to deal theoretically with these obstacles\, and it will present examples of new\, unforeseen\, possibilities for easy preparation and manipulation “on the fly” of quantum states of light and matter. \nCoffee and croissants will be offered after the colloquium in front of the room ! \nPersonne à contacter : Michele Filippone (michele.filippone@cea.fr)
URL:https://sfp-alpes.fr/event/klaus-molmer-niels-bohr-institute-university-of-copenhagen/
LOCATION:CNRS – Salle René Pauthenet (J229)\, CNRS – LNCMI\, 25 avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Séminaire
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DTSTAMP:20260227T144239Z
CREATED:20260227T144116Z
LAST-MODIFIED:20260227T144239Z
UID:10000085-1773756000-1773759600@sfp-alpes.fr
SUMMARY:Montserrat SOLER-LÓPEZ (Macromolecular X-ray Crystallography\, Imaging and Scattering Group\, ESRF)
DESCRIPTION:Mitochondrial Bioenergetics in Alzheimer’s Disease : Insights from the European Synchrotron\nRésumé : \n\nAlzheimer’s disease (AD) is a devastating neurodegenerative disorder increasingly linked to defects in mitochondrial bioenergetics. At the European Synchrotron Radiation Facility (ESRF)\, we investigate the structural and functional mechanisms that underlie mitochondrial dysfunction in AD\, with a focus on respiratory complex I\, a central player in cellular energy production [1\,2]. \nUsing an integrative biology approach\, we combine macromolecular crystallography\, cryo-electron microscopy\, X-ray imaging\, and spectroscopy to analyse the architecture and regulation of mitochondrial complex I and its assembly factors (MCIA proteins) across spatial and temporal scales. Our structural and functional studies reveal novel regulatory mechanisms of energy metabolism\, including phosphorylation-dependent modulation at the interface of respiration and fatty acid oxidation. Importantly\, we demonstrate that AD-related amyloid oligomers disrupt these regulatory processes within neuronal mitochondria\, thereby contributing to oxidative stress and impaired bioenergetics in AD [3\,4]. Recent synchrotron-based imaging\, including X-ray fluorescence and nano-tomography\, has further provided first insights into the ultrastructure of mitochondrial assemblies in situ. \nCollectively\, these findings highlight how the ESRF’s interdisciplinary\, state-of-the-art methodologies enable breakthroughs in deciphering the molecular basis of neurodegeneration\, offering new perspectives for diagnostic markers and therapeutic strategies targeting mitochondrial dysfunction in Alzheimer’s disease. \n[1] Giachin et al. Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases. Front. Mol. Biosci. 2016\, 3:43 \n[2] McGregor & Soler-Lopez. Structural basis of bioenergetic protein complexes in Alzheimer’s disease pathogenesis. Cur Opin Struct Biol. 2023\, 80:102573 \n[3] Giachin et al. Assembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination. Angew. Chem. Int. Ed. 2021\, 60(9):4689 \n[4] McGregor et al. The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination. Nat Commun. 2023\, 14(1):8248 \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/montserrat-soler-lopez-5macromolecular-x-ray-crystallography-imaging-and-scattering-group-esrf/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
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