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DTSTART;TZID=Europe/Paris:20260710T110000
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DTSTAMP:20260703T084646Z
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UID:10000211-1783681200-1783684800@sfp-alpes.fr
SUMMARY:Marion JESPERSEN (Department of Microbiology\, Monash University)
DESCRIPTION:Functional and structural insights into O2-adapted hydrogenases\nRésumé : \nHydrogenases are metalloenzymes that catalyse the interconversion of protons and electrons into molecular hydrogen (H2)\, providing valuable models for robust and sustainable H2 catalysts. However\, most characterised hydrogenases are inhibited by oxygen (O2)\, limiting their biotechnological potential. Although diverse [NiFe]- and [FeFe]-hydrogenases have evolved adaptations that support activity\, stability\, or recovery following O2 exposure\, the molecular basis of O2 adaptation remains poorly understood. \nIn this talk\, I will present our ongoing work on O2-adapted hydrogenases from bacteria and archaea inhabiting aerobic soils\, thermoacidophilic environments\, and the gut. By combining physiological\, biochemical\, structural\, and computational approaches\, we investigate how distinct hydrogenase lineages support H2 metabolism under oxygen-exposed conditions.These systems include the high-affinity group 1h [NiFe]-hydrogenase from Mycobacterium smegmatis\, the Sulfolobales clade 2 [NiFe]-hydrogenase from Metallosphaera sedula\, and gut microbial [FeFe]-hydrogenases\, including group B enzymes from Bacteroides species and a group A1 enzyme from Clostridium perfringens. Together\, they highlight the diversity of hydrogenase architectures\, cofactor arrangements\, and electron-transfer strategies that may contribute to O2 resilience. \nOverall\, this work expands the functional and structural repertoire of O2-adapted hydrogenases\, informing our understanding of microbial H2 metabolism and the search for enzymes suited to H2-based biocatalysis. \n_ \nCes séminaires\, ainsi que les soutenances et cours sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire et de l’adresser\, plus de 48h à l’avance\, à ce contact. Pensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/marion-jespersen-department-of-microbiology-monash-university/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
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