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DTSTART;TZID=Europe/Paris:20260929T110000
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DTSTAMP:20260925T162852Z
CREATED:20260925T162805Z
LAST-MODIFIED:20260925T162852Z
UID:10000279-1790679600-1790683200@sfp-alpes.fr
SUMMARY:Ru-Juan LIU (ShanghaiTech University\, China)
DESCRIPTION:Beyond M6A : TRNA modifications from mechanism to therapeutic engineering\nRésumé : \nRNA modifications are essential regulators of RNA structure and function\, yet much of our mechanistic understanding of tRNA modifications has historically come from studies in bacteria and yeast. How these modifications are precisely installed\, dynamically regulated\, and functionally diversified in higher eukaryotes remains much less understood. By combining RNA mass spectrometry\, high-throughput tRNA sequencing\, and other approaches\, our laboratory has systematically investigated tRNA modifications in mammalian cells. We have identified multiple previously uncharacterized tRNA-modifying and demodification enzymes\, uncovered dynamic regulation and crosstalk among tRNA modifications\, and revealed unexpected functional diversification of RNA-modifying enzymes during evolution\, including expansion of their substrate repertoires from tRNAs to mRNAs and acquisition of non-catalytic functions. Using the m5C methyltransferases NSUN2 and NSUN6 as examples\, I will discuss how these enzymes recognize distinct tRNA and mRNA substrates and how substrate specificity shapes their biological functions. Finally\, I will highlight how these mechanistic insights can be exploited to engineer therapeutic tRNAs and mRNAs with improved properties. \n_ \nContact : appaixfl@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/ru-juan-li-shanghaitech-university-china/
LOCATION:IAB – Salle de séminaire\, IAB Site Santé - Allée des Alpes\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IAB":MAILTO:appaixfl@univ-grenoble-alpes.fr
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DTSTART;TZID=Europe/Paris:20260929T140000
DTEND;TZID=Europe/Paris:20260929T150000
DTSTAMP:20260910T152942Z
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UID:10000248-1790690400-1790694000@sfp-alpes.fr
SUMMARY:Natali PLANK (School of Chemical and Physical Sciences and the MacDiarmid Institute for Advanced Materials and Nanotechnology\, Victoria University of Wellington\, New Zealand)
DESCRIPTION:Nanowire and carbon nanotube device structures for Biosensors and Artificial Neural Networks\nRésumé : \nCarbon nanotube (CNT) networks offer a particularly attractive platform due to their simple fabrication\, tunable electronic properties\, and ability to be interrogated through multiple electrical contacts on a single chip [1]. Functionalised carbon nanotube and graphene field effect transistors (CNTFETs and GFETs) have been used as the active channel in biosensors\, with the future promise of lab-on-a-chip diagnostics strongly motivating the research [2]. The ability to effectively sense analytes depends on multiple factors\, the conductivity of the platform [3]\, the robustness of the functionalisation and the selectivity and function of the receptor [4]. \nCarbon nanotubes also offer an interesting base platform for neuromorphic computing via physical reservoirs. Physical reservoir computing exploits the intrinsic dynamics of complex materials to perform temporal information processing with low power consumption and minimal training requirements. Disordered networks of memristive nanowires have emerged as promising neuromorphic architectures\, as they can host large numbers of nonlinear junctions that collectively generate rich spatiotemporal dynamics [5-7]. \nHere I will present our recent work on the development of the CNTFET and GFET platforms with aptamers and insect odorant receptors and the different challenges and device constraints we have encountered. I will also present our work on the development of the CNT platform for physical reservoir computing applications. \n[1]      Topinka\, M. A\, et al. Nano Lett. 2009 9\, 1866–1871 \n[2]      T An et al\, Lab Chip\, 2010\,10\,2052-2056 \n[3]      M Thanihaichelvan M\, et al\, Biosensors and Bioelectronics\, 2019\, 130\, 408-413 \n[4]      Nguyen et al.\, Nanomaterials\, 2021 11 (9)\, 2280 \n[5]      Milano\, G\, et al. Nat. Mater. 2022\, 21 (2)\, 195–202. \n[6]      Kotooka\, T.\, et al. Thermally Stable Ag 2 Se Nanowire Network as an Effective In-Materio Physical Reservoir Computing Device. 2024\, 2400443\, 1–10.  \n[7]      Zhu\, R.\, et al Online Dynamical Learning and Sequence Memory with Neuromorphic Nanowire Networks. Nat. Commun. 2023\, 14 (1)\, 6697.  \n\nShort Bio/CV\nDr Natalie Plank is Deputy Director for Commercialisation and Industry Engagement and an Associate Professor in Physics in the School of Chemical and Physical Sciences at Victoria University of Wellington. Natalie completed a BSc (Hons) in Astrophysics at The University of Edinburgh before doing an MSc in Microelectronics. She then completed her PhD on the functionalisation of carbon nanotubes for molecular electronics with Rebecca Cheung also at The University of Edinburgh. \nNatalie’s research interests are in the area of nanomaterial device fabrication and the characterisation of novel materials. Her current work focuses on nanomaterial device platforms for sensing technology and artificial neural networks. She is interested in carbon nanotubes and ZnO nanowires for nanowire transistor applications and in particular the ability to functionalise the nanomaterial channels with specific biomarkers or memristive molecules. Natalie’s core interests are in low cost fabrication techniques which allow for high throughput of devices whilst maintaining the particular material properties of the unique nanowire system. \n_ \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/natali-plank-school-of-chemical-and-physical-sciences-and-the-macdiarmid-institute-for-advanced-materials-and-nanotechnology-victoria-university-of-wellington-new-zealand/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
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