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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260206T110000
DTEND;TZID=Europe/Paris:20260206T120000
DTSTAMP:20260404T144231
CREATED:20260129T162542Z
LAST-MODIFIED:20260130T141840Z
UID:10000040-1770375600-1770379200@sfp-alpes.fr
SUMMARY:David SKURNIK (Hôpital Necker- Enfants Malades\, Université Paris Cité)
DESCRIPTION:New approaches in vaccine development\nRésumé : \nHigh-throughput sequencing and particularly original applications such as the TnSeq allow a study of host-pathogen interaction at the full genome scale through a systematic analysis off all the virulence factors of a bacteria in a particular setting. For example\, all the genes important or essential for GI tract colonization of the selected pathogenic bacteria. \nThis allows to reveal new targets for vaccine development. Interestingly\, an ongoing adaptation of the TnSeq allows the systematic identification of these antigens of interest. We call this new technology : TnVaccine. \nContact : ibs.seminaires@ibs.fr
URL:https://sfp-alpes.fr/event/david-skurnik-hopital-necker-enfants-malades-universite-paris-cite/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260212T130000
DTEND;TZID=Europe/Paris:20260212T140000
DTSTAMP:20260404T144231
CREATED:20260124T035658Z
LAST-MODIFIED:20260129T135753Z
UID:10000030-1770901200-1770904800@sfp-alpes.fr
SUMMARY:Delphine ROPERS (Inria – Grenoble)
DESCRIPTION:Computational analyses of bacterial mRNA decay\n  \nPlus d’informations : https://bi-gre.github.io/ \nContact : lucie.lamothe@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/delphine-ropers-inria-grenoble/
LOCATION:IMAG – Salle de Réunion\, 150 place du Torrent\, St Martin d’Hères\, 38400\, France
CATEGORIES:Séminaire
ORGANIZER;CN="TIMC - IMAG":MAILTO:lucie.lamothe@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260212T140000
DTEND;TZID=Europe/Paris:20260212T150000
DTSTAMP:20260404T144231
CREATED:20260130T094628Z
LAST-MODIFIED:20260130T102105Z
UID:10000042-1770904800-1770908400@sfp-alpes.fr
SUMMARY:Youngsuk KIM (Pusan National University\, Busan\, South Korea (visiting scientist @ DCM))
DESCRIPTION:Carbene–CS2 : Redox-active Radical Ligands\nContact : david.martin@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/youngsuk-kim-pusan-national-university-busan-south-korea-visiting-scientist-dcm/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260219T113000
DTEND;TZID=Europe/Paris:20260219T123000
DTSTAMP:20260404T144231
CREATED:20260212T155849Z
LAST-MODIFIED:20260212T155849Z
UID:10000059-1771500600-1771504200@sfp-alpes.fr
SUMMARY:Sharlen MOORE (Johns Hopkins University\, Baltimore\, USA)
DESCRIPTION:Revealing abrupt transitions from goal-directed to habitual behavior\nRésumé : \nA fundamental tenet of animal behavior is that decision-making involves multiple ‘controllers.’ Initially\, behavior is goal-directed\, driven by desired outcomes\, shifting later to habitual control\, where cues trigger actions independent of the motivational state. Clark Hull’s question from 1943 still resonates today: “Is this transition [to habit] abrupt\, or is it gradual and progressive?” Despite a century-long belief in gradual transitions\, this question remains unanswered as current methods cannot disambiguate goal-directed versus habitual control in real time. Here\, we introduce a novel ‘volitional engagement’ approach\, motivating animals by palatability rather than biological need. Providing less palatable water in the home cage reduced motivation to ‘work’ for plain water in an auditory discrimination task compared to water-restricted animals. Using quantitative behavior and computational modeling\, we found that palatability-driven animals learned to discriminate as quickly as water-restricted animals but exhibited state-like fluctuations when responding to the reward-predicting cue-reflecting goal-directed behavior. After thousands of trials\, these fluctuations spontaneously and abruptly ceased\, with animals always responding to the reward-predicting cue. In line with habitual control\, post- transition behavior displayed motor automaticity\, decreased error sensitivity (assessed via pupillary responses)\, and insensitivity to sensory-specific outcome devaluation. Bilateral lesions of the habit-related dorsolateral striatum (DLS) blocked transitions to habitual behavior. Finally\, we used bilateral fiber photometry in the putative controllers of goal-directed (dorsomedial striatum\, DMS) and habitual (DLS) behavior to monitor the evolution of neural activity across learning. Both the DMS and DLS exhibited learning- related signatures in cue\, lick\, and outcome-related signaling at similar timescales in parallel. Immediately after transitioning to habitual behavior\, outcome-related signaling was suppressed in the DLS and\, to a lesser extent\, in the DMS\, while cue-evoked responses further sharpened. This abrupt shift (reduction in outcome signaling and sharpening of cue-evoked responses) suggests that sensory cues rather than outcomes drive habitual responding. Our results demonstrate that both controllers (DMS and DLS) exhibit learning-related plasticity in parallel but that the behavioral manifestation of habits emerges spontaneously and abruptly in a DLS-dependent manner\, suggesting the involvement of a higher-level process that arbitrates between the two. \nContact : robin.magnard@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/sharlen-moore-johns-hopkins-university-baltimore-usa/
LOCATION:GIN – Amphi Serge Kampf\, Grenoble Institut des Neurosciences (GIN) Bât. Edmond J. Safra\, Chemin Fortune Ferrini CHU\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
ORGANIZER;CN="GIN":MAILTO:yves.goldberg@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260224T183000
DTEND;TZID=Europe/Paris:20260224T183000
DTSTAMP:20260404T144231
CREATED:20260222T085804Z
LAST-MODIFIED:20260222T090042Z
UID:10000072-1771957800-1771957800@sfp-alpes.fr
SUMMARY:Sophie Abby (TIMC\, Grenoble)
DESCRIPTION:Le premier souffle : comment les microbes ont oxygéné la Terre\nRésumé :  \nCette soirée explore la diversité du vivant à travers l’arbre phylogénétique\, en s’appuyant sur les travaux du projet Quinevol qui étudie les quinones\, molécules essentielles présentes dans tous les organismes vivants. Comment les organismes primitifs respiraient-ils avant l’apparition de l’oxygène ? Comment se sont-ils ensuite adaptés à ce qui était alors un véritable poison ? Un voyage scientifique des origines de la vie jusqu’aux frontières de la recherche actuelle. \n 
URL:https://sfp-alpes.fr/event/sophie-abby-timc-grenoble/
LOCATION:Museum de Grenoble\, 1 Rue Dolomieu\, Grenoble\, 38000\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260226T130000
DTEND;TZID=Europe/Paris:20260226T140000
DTSTAMP:20260404T144231
CREATED:20260130T162946Z
LAST-MODIFIED:20260213T084606Z
UID:10000050-1772110800-1772114400@sfp-alpes.fr
SUMMARY:Céline SCORNAVACCA (ISEM – Montpellier)
DESCRIPTION:A New Algorithm for Computing the Likelihood of a Phylogeny\nContact : lucie.lamothe@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/celine-scornavacca-isem-montpellier/
LOCATION:IMAG – Salle de Réunion\, 150 place du Torrent\, St Martin d’Hères\, 38400\, France
CATEGORIES:Séminaire
ORGANIZER;CN="TIMC - IMAG":MAILTO:lucie.lamothe@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260226T140000
DTEND;TZID=Europe/Paris:20260226T150000
DTSTAMP:20260404T144231
CREATED:20260130T095731Z
LAST-MODIFIED:20260130T102010Z
UID:10000043-1772114400-1772118000@sfp-alpes.fr
SUMMARY:Paulo Henrique MACIEL BUZZETTI (Département de Chimie Moléculaire\, équipe I2BM (nouvel entrant))
DESCRIPTION:From Bio-analytics & Bio-energy : A Journey Through Functional Interfaces & Supramolecular Architectures\nContact : quentin.laurent@univ-grenoble-alpes.fr 
URL:https://sfp-alpes.fr/event/paulo-henrique-maciel-buzzetti-departement-de-chimie-moleculaire-equipe-i2bm-nouvel-entrant/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260227T110000
DTEND;TZID=Europe/Paris:20260227T120000
DTSTAMP:20260404T144231
CREATED:20260129T163105Z
LAST-MODIFIED:20260130T142401Z
UID:10000041-1772190000-1772193600@sfp-alpes.fr
SUMMARY:Jean-Francois COLLET (Institut de Duve\, Bruxelles)
DESCRIPTION:How (and Why) do Gram-Negative Bacteria build an Outer Membrane\nRésumé :  \nGram-negative bacteria are defined by a complex cell envelope in which the outer membrane plays a central role in protection\, nutrient exchange\, and antibiotic resistance. This asymmetric lipid bilayer forms a robust permeability barrier\, yet its biogenesis presents a striking challenge : all outer membrane components are synthesized in the cytoplasm or at the inner membrane and must be transported and assembled across the periplasm without direct energy input. In this talk\, I will discuss how Gram-negative bacteria build their outer membrane and why this process is essential for cellular physiology. I will introduce the major pathways responsible for outer membrane assembly and highlight how their activities need to be coordinated to maintain envelope integrity. I will also present recent work showing that the outer membrane is not merely a passive barrier\, but a mechanically active structure that enables the buildup of periplasmic pressure\, a property critical for envelope stability and bacterial survival. Together\, these findings underscore the outer membrane as a dynamic\, multifunctional organelle and a promising target for future antibacterial strategies. \nContact : ibs.seminaires@ibs.fr
URL:https://sfp-alpes.fr/event/jean-francois-collet-institut-de-duve-bruxelles/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
END:VEVENT
END:VCALENDAR