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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260703T093000
DTEND;TZID=Europe/Paris:20260703T113000
DTSTAMP:20260625T141107Z
CREATED:20260625T141107Z
LAST-MODIFIED:20260625T141107Z
UID:10000206-1783071000-1783078200@sfp-alpes.fr
SUMMARY:Soutenance de thèse par Léonard OLIVOTTO (CEA-Irig/LCBM)
DESCRIPTION:Conception de catalyseurs hybrides enzyme/nanomatériaux et de solvants sur mesure pour réduire le CO2 par des procédés photochimiques et électrochimiques en présence d’oxygène\nRésumé : \nDans la recherche de nouvelles voies de valorisation du CO2 respectueuses de l’environnement\, l’utilisation d’enzymes représente une approche prometteuse. Parmi elles\, la monoxyde de carbone déshydrogénase (NiFe-CODH) réduit de manière réversible le CO2 en CO avec une performance et une sélectivité remarquable en conditions douces. Pour ces raisons\, plusieurs études ont exploré les [NiFe]-CODH en vue d’applications dans la réduction électrocatalytique et photocatalytique du CO2.\nCependant\, l’extrême sensibilité à l’oxygène de leur site actif constitué d’un centre multimétallique NiFE4S4\, limite leur intégration dans des dispositifs industriels. Par conséquent\, plusieurs stratégies ont été développées pour améliorer la tolérance à l’O2 des systèmes électrocatalytiques et photocatalytiques à base d’enzymes. Parmi celles-ci\, l’utilisation de solvants eutectiques profonds (DES) s’est avérée être une méthode intéressante pour la production photocatalytique d’hydrogène à base d’enzymes. \nDans cette thèse\, plusieurs méthodes de modification de surface pour la conception d’électrodes à base de nanotubes de carbone visant à optimiser l’interface CODH-électrode et\, par conséquent\, à améliorer les performances électrocatalytiques pour la réduction du CO2 ont été développées. Une fois optimisées en milieu aqueux\, les performances des bioélectrodes ont été étudiées dans des DES\, et l’effet protecteur de ce solvant non conventionnel contre l’exposition à l’O2 a été exploré. Les connaissances acquises jusque-là ont finalement été réutilisées pour développer des photosystèmes hybrides semi-conducteur-enzyme (SEHP). Le nitrure de carbone a été modifié par une méthode de greffage au diazonium\, caractérisé et démontré comme coopérant avec la CODH pour réaliser de la photoproduction de CO.\nLe système était également opérationnel dans un DES\, avec des performances catalytiques améliorées\, ce qui laisse entrevoir un avenir prometteur pour le développement de SEHP à base de CODH sensibles à l’O2. \nDans l’ensemble\, ces travaux constituent une nouvelle étape vers l’intégration de biocatalyseurs sensibles à l’O2 dans les technologies pertinentes d’utilisation du CO2. ​​​​ \n_ \nContact : alain.farchi@cea.fr \n 
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-leonard-olivotto-cea-irig-lcbm/
LOCATION:Bâtiment André Rassat / Chimie E – Salle de conférence RDC​\, 470 rue de la Chimie\, Gières\, 38610\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260703T110000
DTEND;TZID=Europe/Paris:20260703T120000
DTSTAMP:20260703T084805Z
CREATED:20260626T133757Z
LAST-MODIFIED:20260703T084805Z
UID:10000210-1783076400-1783080000@sfp-alpes.fr
SUMMARY:Catherine ROYER (Rensselaer Polytechnic Institute\, New York)
DESCRIPTION:Pressure-based mapping of protein conformational landscapes\nRésumé : \nProtein function depends upon dynamics\, and while in recent years great progress has been made in predicting protein structure from sequence\, the sequence determinants of functional dynamics have yet to be defined. We have developed an approach using a combination of high-pressure NMR\, SAXS\, fluorescence\, and computation to locally and globally map protein stability and functional dynamics. On a model repeat protein system we find that single amino acid substitutions lead to large changes in local stability and apparent folding cooperativity\, while global stabilities of the variant proteins are similar. In the case of the Arf GTPases\, which undergo massive conformational changes during their nucleotide switch transition\, we demonstrated that the switch mechanism implicates the population of a functional molten globule. Moreover\, we discovered the sequence determinants of back-to-front allosteric control of the switch that differentiates switching probabilities of the Arf family members\, and likely many other small GTPases. \n_ \nCes séminaires\, ainsi que les soutenances et cours sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire et de l’adresser\, plus de 48h à l’avance\, à ce contact. Pensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/catherine-royer-rensselaer-polytechnic-institute-new-york/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260706T110000
DTEND;TZID=Europe/Paris:20260706T120000
DTSTAMP:20260702T131525Z
CREATED:20260702T131457Z
LAST-MODIFIED:20260702T131525Z
UID:10000212-1783335600-1783339200@sfp-alpes.fr
SUMMARY:Guillaume MESTDAGH (INRIA Montbonnot)
DESCRIPTION:Coupling osmosis and mechanics in vertex-based models for plant tissue growth\nRésumé : \nUnderstanding plant growth is fundamental to address global challenges such as food security\, biodiversity\, and soil‑erosion control. The development of plants involves many interconnected physical processes\, occurring at various spatial and temporal scales\, making modeling an indispensable complement to experiments. In particular\, discrete vertex-based models have successfully described the coupling between inter-cell water fluxes and mechanical deformations of cell walls\, in response to a prescribed inner water pressure. \nA two-dimensional vertex-based model represents a group of cells as a tiling of polygons\, with the edges between polygons representing cell walls. Existing vertex-based models postulate a fixed water pressure inside cells as the force driving growth. In reality\, this inner pressure itself is the consequence of osmosis\, a chemical process by which water is attracted into cells with a higher concentration of solute. However\, capturing the interplay between mechanics and solute dynamics in plant tissues into one model remains a challenge that requires novel mathematical frameworks. \nIn this talk\, I will present a new approach to couple solute and water fluxes with mechanics and growth in vertex-based models. The proposed approach is based on a variational formalism where the system physics is described in terms of free energy and dissipation function. After building the model and deriving the evolution equations of the system\, I will show that the resulting formulation can be turned into a numerical method. Finally\, I will illustrate the model properties through a few numerical simulations and discuss its interest for the study of plant growth. \nContact : philippe.marmottant@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/uillaume-mestdagh-inria-montbonnot/
LOCATION:LiPhy – Salle de conférence\, LiPhy 140 avenue de la Physique\, St Martin d'Hères\, 38402\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260707T110000
DTEND;TZID=Europe/Paris:20260707T120000
DTSTAMP:20260702T132320Z
CREATED:20260702T132320Z
LAST-MODIFIED:20260702T132320Z
UID:10000213-1783422000-1783425600@sfp-alpes.fr
SUMMARY:Jérémie TOPIN (Department of Chemistry\, Université Côte d'Azur\, Nice)
DESCRIPTION:The molecular language of smell : reading odors through receptors\nRésumé : \nThis morning\, you may have enjoyed a cup of coffee or tea and felt that its aroma had stimulated your sense of smell. The volatile molecules in your favourite beverage are recognized by the olfactory receptors (ORs) expressed in your olfactory epithelium. But among your 400 ORs\, which ones were activated by these molecules ?\nTo answer this question\, and more generally to determine the molecular recognition spectrum of ORs\, we design the Molecule to Olfactory Receptor M2OR database\n(https://m2or.chemsensim.fr/)\, which brings together 75\,050 bioassay experiments for 51\,683 distinct OR-molecule pairs.[1] We further combine protein language[2] with graph neural networks to predict OR activation\, and propose a tailored architecture incorporating inductive biases from the protein-molecule interaction.[3] This model outperforms state-of-the-art drug- target interaction prediction models as well as standard GNN baselines. Notably\, our predictions are in agreement with combinatorial coding theory in olfaction. \nReferences\n[1] Lalis\, M.\, Hladiš\, M.\, Khalil\, S. A.\, Briand\, L.\, Fiorucci\, S.\, & Topin\, J\, 2024. M2OR: a database of olfactory receptor–odorant pairs for understanding the molecular mechanisms of olfaction. Nucleic Acids Research\, 52(D1)\, D1370-D1379.\n[2] Elnaggar\, A.\, Heinzinger\, M.\, Dallago\, C.\, Rehawi\, G.\, Wang\, Y.\, Jones\, L.\, … & Rost\, B. (2021). Prottrans: Toward understanding the language of life through self-supervised learning. IEEE transactions on pattern analysis and machine intelligence 2022\, 44(10)\, 7112-7127.\n[3] Hladiš\, M.\, Lalis\, M.\, Fiorucci\, S.\, & Topin\, J. Matching receptor to odorant with protein language and graph neural networks 2023. In The Eleventh International Conference on Learning Representations. \nContact : lucie.sancey@univ-grenoble-alpes.fr ou emmanuel.brun@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/jeremie-topin-department-of-chemistry-universite-cote-dazur-nice/
LOCATION:IAB – Salle de séminaire\, IAB Site Santé - Allée des Alpes\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IAB":MAILTO:appaixfl@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260709T140000
DTEND;TZID=Europe/Paris:20260709T160000
DTSTAMP:20260625T143634Z
CREATED:20260625T143510Z
LAST-MODIFIED:20260625T143634Z
UID:10000208-1783605600-1783612800@sfp-alpes.fr
SUMMARY:Soutenance de thèse par Lorenzo LOMBARDI (CEA-Irig/SyMMES)
DESCRIPTION:Production d’hydrogène à partir de points quantiques par photoélectrolyse de l’eau\nRésumé : \nLes boites quantiques (QD) sont des nanomatériaux semi-conducteurs prometteurs pour la production d’hydrogène par énergie solaire\, grâce à leur forte absorption lumineuse\, leurs coefficients d’extinction élevés et leurs propriétés électroniques modulables. Le développement d’alternatives respectueuses de l’environnement aux QD à base de cadmium est essentiel pour une dissociation de l’eau par voies photocatalytiques et photoélectrochimiques (PEC) durables. Dans ce contexte\, cette thèse étudie les QD à base de CuIn(Ga)S2 pour la production d’hydrogène par photo(électro)lyse de l’eau\, en mettant l’accent sur la relation entre synthèse\, chimie de surface et propriétés optoélectroniques.\nLes travaux explorent d’abord la synthèse organique de QD Cu(In)GaS2 par injection à chaud et chauffage\, combinée à l’ingénierie de l’enveloppe. L’injection à chaud permet d’obtenir des QD CuGaS2/ZnS/ZnS fortement émissifs\, mais des problèmes de purification liés à des résidus de précurseurs sont observés\, limitant la reproductibilité. Les méthodes de chauffage offrent un meilleur contrôle de croissance et une procédure plus simple. Des structures multishell (ZnS\, GaSx\, Al2O3) améliorent la stabilité colloïdale et améliorent les propriétés de photoluminescence. Les positions de bandes sont compatibles avec la production d’hydrogène\, comme confirmé par des analyses électrochimiques et spectroscopiques\, et l’échange de ligands permet le transfert des QD vers des milieux aqueux.\nLa thèse se concentre ensuite sur les synthèses aqueuses (batch\, micro-ondes et flux continu)\, plus durables et facilement scalables. Une nouvelle synthèse hydrothermique assistée par micro-ondes de QD CuInGaS2/GaSx est développée pour étudier l’incorporation du gallium en fonction des ligands. Différents ligands et architectures de surface sont explorés\, montrant un impact marqué sur composition et propriétés optiques. Seuls certains ligands aminocarboxyliques favorisent l’incorporation du gallium\, mise en évidence par spectroscopie d’absorption des rayons X\, tandis que la diffusion neutronique à petit angle fournit des informations structurales complémentaires. La structure électronique est étudiée par voltamétrie cyclique\, XPS\, UPS et PYSA\, corrélant niveaux de bande et performances. Une synthèse en flux continu de QD CuInGaS2 est également mise au point\, démontrant la scalabilité du procédé. Ces approches conduisent à des QD stables présentant des rendements quantiques jusqu’à 20 % et des durées de vie supérieures à 300 ns.\nEnfin\, les performances photocatalytiques et photoélectrochimiques sont évaluées. En photocatalyse\, les QD CuIn(Ga)S2 recouverts de glutathion produisent de l’hydrogène sans cocatalyseur\, tandis que leur association avec des catalyseurs moléculaires permet d’atteindre des TON jusqu’à 12047\, parmi les plus élevés pour des QD sans métaux lourds. En PEC\, des électrodes de TiO2 sensibilisées présentent des photocourants anodiques jusqu’à 1\,45 mA/cm2 à 1\,23 V vs RHE en conditions neutres et sans donneur de trous\, plaçant ces systèmes parmi les plus performants. L’ajout de CoPi entraîne une augmentation modeste du photocourant (5 %) et un décalage cathodique de 0\,2 V\, indiquant que les limitations proviennent surtout des processus de génération\, d’injection et de transport de charge plutôt que de la cinétique catalytique.\nDans l’ensemble\, ce travail démontre le fort potentiel des QD CuIn(Ga)S2 pour la production d’hydrogène durable. Il met en évidence le rôle central de la stratégie de synthèse\, du contrôle de la chimie de surface\, de la gestion des défauts et de l’ingénierie interfaciale pour optimiser les performances photocatalytiques et photoélectrochimiques. Ces résultats fournissent une base solide pour le développement de systèmes à base de QD efficaces et évolutifs pour la conversion de l’énergie solaire en carburants chimiques.​​​​​ \n_ \nContact : alain.farchi@cea.fr
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-lorenzo-lombardi-cea-irig-symmes/
LOCATION:GreEN-ER – Amphi 2A006\, 21 avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Soutenance,Soutenance de Thèse
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260710T110000
DTEND;TZID=Europe/Paris:20260710T120000
DTSTAMP:20260703T084646Z
CREATED:20260626T134823Z
LAST-MODIFIED:20260703T084646Z
UID:10000211-1783681200-1783684800@sfp-alpes.fr
SUMMARY:Marion JESPERSEN (Department of Microbiology\, Monash University)
DESCRIPTION:Functional and structural insights into O2-adapted hydrogenases\nRésumé : \nHydrogenases are metalloenzymes that catalyse the interconversion of protons and electrons into molecular hydrogen (H2)\, providing valuable models for robust and sustainable H2 catalysts. However\, most characterised hydrogenases are inhibited by oxygen (O2)\, limiting their biotechnological potential. Although diverse [NiFe]- and [FeFe]-hydrogenases have evolved adaptations that support activity\, stability\, or recovery following O2 exposure\, the molecular basis of O2 adaptation remains poorly understood. \nIn this talk\, I will present our ongoing work on O2-adapted hydrogenases from bacteria and archaea inhabiting aerobic soils\, thermoacidophilic environments\, and the gut. By combining physiological\, biochemical\, structural\, and computational approaches\, we investigate how distinct hydrogenase lineages support H2 metabolism under oxygen-exposed conditions.These systems include the high-affinity group 1h [NiFe]-hydrogenase from Mycobacterium smegmatis\, the Sulfolobales clade 2 [NiFe]-hydrogenase from Metallosphaera sedula\, and gut microbial [FeFe]-hydrogenases\, including group B enzymes from Bacteroides species and a group A1 enzyme from Clostridium perfringens. Together\, they highlight the diversity of hydrogenase architectures\, cofactor arrangements\, and electron-transfer strategies that may contribute to O2 resilience. \nOverall\, this work expands the functional and structural repertoire of O2-adapted hydrogenases\, informing our understanding of microbial H2 metabolism and the search for enzymes suited to H2-based biocatalysis. \n_ \nCes séminaires\, ainsi que les soutenances et cours sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire et de l’adresser\, plus de 48h à l’avance\, à ce contact. Pensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/marion-jespersen-department-of-microbiology-monash-university/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260720T110000
DTEND;TZID=Europe/Paris:20260720T120000
DTSTAMP:20260703T133346Z
CREATED:20260703T133346Z
LAST-MODIFIED:20260703T133346Z
UID:10000216-1784545200-1784548800@sfp-alpes.fr
SUMMARY:Garry S. HANAN (Département de chimie\, Université de Montréal\, Canada)
DESCRIPTION:Developing New Photosensitizers based on Transition Metal Ions for Green Energy Applications\nRésumé : \nRising global population and increased CO2 levels in the atmosphere have focused attention on developing alternative and widely available carbon-free energy sources (1\,2). Ourresear ch focuses on harnessing the unique properties of excited states in metal complexes to drive self-assembly processes and develop innovative energy applications. By leveraging the photophysical and photochemical behaviors of these complexes\, we explore how light-induced excitations can be utilized to control molecular organization and energy transfer at the nanoscale. The parallels with Natural Photosynthesis are evident: light energy is captured by self-assembled Light Harvesting Complexes and is channeled to a reaction centre which induces electron transfer and the eventual production of chemical energy (3). \nOur approach involves the synthesis of polypyridyl-based metal complexes\, which are known for their stability and tunable electronic properties. By manipulating the excited states of these complexes\, we demonstrate how light can act as a stimulus to induce self-assembly\, leading to the formation of well-defined nanostructures with potential applications in catalysis\, sensing\, and optoelectronics (4). Additionally\, we extend our approach to the development of photoactive molecular devices capable of storing and transferring electrons\, offering insights into the design of next-generation photosensitizers for chemical energy production (5). We have also moved from second- and third-row transition metal ions to the first row\, and explore energy applications of these abundant\, inexpensive and relatively non-toxic metal ions (6). \nReferences\n1. https://ourworldindata.org/world-population-growth (01-05-2026).\n2. https://www.iea.org/world (01-05-2026).\n3. V. Balzani\, A. Credi\, M. Venturi\, Chem Sus Chem 2008\, 1\, 26.\n4. B. Laramée-Milette\, F. Puntoriero\, F. Nastasi\, S. Campagna\, G. S. Hanan\, Chem. Eur. J.\, 2017 23\, 16497.\n5. G. M. Mercier\, E. Rousset\, I. Oubaha\, K. Bandyopadhyay\, A. K. Pal\, I. Ciofini\, L.-M. Chamoreau\, V. Marvaud\, G. S. Hanan\, Chem. Commun. 2025 61 (77)\, 14911-14914.\n6. A. Saha\, G. Turner\, M. Cibian\, S. Serroni\, S. Genovese\, S. Campagna\, G. S. Hanan\, F. Nastasi\, submitted for publication. \nGarry Hanan is professor in the Department of Chemistry at the Université de Montréal\, where he leads the Green Energy Group and is a member of the Centre for Green Chemistry and Catalysis. He earned his B. Sc. from the University of Winnipeg\, Canada\, his PhD from Université Louis Pasteur in Strasbourg\, France\, under the supervision of Jean-Marie Lehn and subsequently conducted postdoctoral studies in Germany with Manfred T. Reetz and in Italy with Vincenzo Balzani and Sebastiano Campagna. Professor Hanan’s research focuses on the design and synthesis of supramolecular photocatalysts capable of harvesting solar energy to drive chemical\ntransformations\, most notably the photoproduction of fuels via water-splitting (producing H₂) and CO₂ reduction.\nHe has received numerous distinctions\, including awards from IUPAC and NSERC\, highlighting his contributions to sustainable chemistry and molecular materials science. He also actively promotes international student exchange. \nContact : frederique.loiseau@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/garry-s-hanan-departement-de-chimie-universite-de-montreal-canada/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260721T140000
DTEND;TZID=Europe/Paris:20260721T150000
DTSTAMP:20260709T121303Z
CREATED:20260709T121303Z
LAST-MODIFIED:20260709T121303Z
UID:10000218-1784642400-1784646000@sfp-alpes.fr
SUMMARY:Ben HUMPHREYS (Institut Laue-Langevin (ILL) Grenoble\, France)
DESCRIPTION:Advancing our Understanding of Responsive Polymer Brushes\nRésumé : \n\nInterfacial properties of a surface can be extensively modified through the addition of a polymer brush layer; a dense array of end-tethered polymers grafted to a surface. When a polymer brush is synthesised with a stimulus responsive polymer\, the surface properties can be tailored to respond\, often reversibly\, to external stimuli such as temperature\, light\, pH\, solvent or electric fields. While these so-called smart materials are particularly promising for high-value applications such as sensors\, nanoactuation and microfluidics\, their response can be significantly influenced by additives such as osmolytes and salts. Unlike untethered polymer systems\, research into the influence of additives for responsive polymer brushes has been sparse\, yet this knowledge is crucial when advancing their utilisation in biomedical and industrial applications. \nThroughout my research career I have primarily focused on the influence of salts and osmolytes on temperature and pH responsive homo- and co-polymer brushes. I will firstly discuss my synthetic methodologies and choice of responsive polymers. This will be followed by a comprehensive outline of the approaches used to investigate these responsive coatings. Here\, starting with the simplest systems\, then gradually increasing complexity\, I have been able to systematically understand the influence of individual additives/changes. This information is invaluable when considering the complex real-world applications that can benefit from the utilisation of smart\, responsive polymer brush surface coatings. \nShort Bio/CV\nIn 2015 I graduated from the University of Newcastle\, Australia\, with a Bachelor of Science\, 1st class honors\, majoring in Chemistry\, followed by my PhD at the same university (2015-2019) titled “Nanostructure of Temperature Responsive Polymer Brushes Modulated by Salt Identity”. I then accepted a post-doc position at Lund University in Sweden\, investigating the internal structural changes of a triglyceride film throughout enzymatic digestion\, with particular focus on the influence of pH and how this influences the species present throughout the lipolytic process. In 2023 I started in my current position as instrument responsible for the D17 neutron reflectometer at the ILL where I have re-established my research on responsive polymer brushes with a focus on osmolyte and salt additives in aqueous solutions. \n_ \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/ben-humphreys-institut-laue-langevin-ill-grenoble-france/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260908T110000
DTEND;TZID=Europe/Paris:20260908T120000
DTSTAMP:20260903T153516Z
CREATED:20260903T153408Z
LAST-MODIFIED:20260903T153516Z
UID:10000238-1788865200-1788868800@sfp-alpes.fr
SUMMARY:Delphine DELACOUR (IBDM \, Marseille (France))
DESCRIPTION:Deciphering the principles of epithelial tissue organization\nRésumé : \nEpithelia constitute the primary physical barrier against external insults while simultaneously ensuring organ function. Defects in epithelial assembly or function lead to a broad spectrum of pathological conditions\, ranging from rare developmental disorders to cancer. Despite their fundamental importance\, the mechanisms by which epithelial cells coordinate individual behaviors across entire tissues to ensure spatial organization\, integrity\, and function remain poorly understood. To date\, epithelial coherence has been studied predominantly in invertebrate systems or in transformed cell lines\, limiting our understanding of its regulation in physiological mammalian contexts.\nThe intestinal epithelium represents an exceptional model to address these questions. It is one of the most rapidly renewing tissues in mammals and is continuously exposed to challenges. Its homeostasis relies on the precise balance between cell proliferation\, differentiation\, migration\, and death. However\, the cellular and developmental principles governing intestinal tissue organization and maintenance remain largely unexplored. \nThe overarching objective of this project is to elucidate how functional domains of the intestinal epithelium are established\, maintained\, and coordinated in space and time. Specifically\, the project aims to : \n1. understand the mechanisms that preserve the integrity of the proliferative compartment and determine their role in crypt formation and maintenance ;\n2. uncover epithelial connectivity and collective behavior within the differentiated compartment\, both under homeostatic conditions and in response to perturbations. \nA major strength of this project lies in its integrative and comparative strategy\, combining in vivo and in vitro murine models with human disease-relevant systems. The project brings together advanced approaches in cell and developmental biology\, tissue engineering\, histology\, molecular biology\, biophysics\, and computational modeling. This multidisciplinary framework will enable the identification of adaptive mechanisms by which epithelial cells polarize\, self-organize\, and dynamically regulate their fate in response to their environment\, with broad implications for developmental biology\, regenerative medicine\, and disease pathology. \n_ \nContact : monika.dolega@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/delphine-delacour-ibdm-marseille-france/
LOCATION:IAB – Salle de séminaire\, IAB Site Santé - Allée des Alpes\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IAB":MAILTO:appaixfl@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260911T110000
DTEND;TZID=Europe/Paris:20260911T120000
DTSTAMP:20260827T154120Z
CREATED:20260827T154120Z
LAST-MODIFIED:20260827T154120Z
UID:10000226-1789124400-1789128000@sfp-alpes.fr
SUMMARY:Alexander BRONSTEIN (Institute of Science & Technology\, Autriche)
DESCRIPTION:Experiment-guided generative models for protein structure and dynamics\nRésumé : \n\nProteins exist as a dynamic ensemble of multiple conformations\, and these motions are often crucial for their functions. However\, current structure prediction methods predominantly yield a single conformation\, overlooking the conformational heterogeneity revealed by diverse experimental modalities. I will present a framework for building experiment-grounded protein structure generative models that infer conformational ensembles consistent with measured experimental data. The key idea is to treat state-of-the-art protein structure predictors (e.g.\, AlphaFold3) as sequence-conditioned structural priors\, and cast ensemble modeling as posterior inference of protein structures given experimental measurements. Through extensive real-data experiments\, I will demonstrate the generality of our method to incorporate a variety of experimental measurements. In particular\, our framework uncovers previously unmodeled conformational heterogeneity from crystallographic densities\, and generates high-accuracy NMR ensembles orders of magnitude faster than the state-of-the-art and often better fitting the experimental data than the publicly deposited structures to the Protein Data Bank. I believe that this approach will unlock building predictive models that fully embrace experimentally observed conformational diversity.​\n_\n​\n\n\n\nLes séminaires et soutenances sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire  et de l’adresser\, plus de 48h à l’avance\, à ce contact.\nPensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/alexander-bronstein-institute-of-science-technology-autriche/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260914T140000
DTEND;TZID=Europe/Paris:20260914T150000
DTSTAMP:20260910T141150Z
CREATED:20260910T141150Z
LAST-MODIFIED:20260910T141150Z
UID:10000242-1789394400-1789398000@sfp-alpes.fr
SUMMARY:Alberto CARTA ( Laboratory for Material simulations\, Paul Scherrer Institut\, Villigen)
DESCRIPTION:Of bandits and Bohr magnetons : balancing exploration and exploitation in magnetic landscapes\nRésumé : \nThe energy landscape of strongly interacting magnetic materials is a high-dimensional\, rugged terrain populated by a multitude of metastable states with distinct magnetizations\, oxidation states\, and orbital orders. Identifying the true ground state within this complexity remains a significant hurdle for the computational design of materials with tunable magnetic properties.\nBuilding on the work of Ponet et al. [1\,2]\, we systematically characterize this terrain to reveal the fundamental drivers of its complexity. We trace its origins to a core competition between the DFT functional’s preference for delocalization and the Hubbard +U correction’s drive for localization. This primary conflict is further modulated by a hierarchy of magnetic interactions\, including Hund’s coupling\, superexchange\, and Kugel-Khomskii physics\, which collectively define the energetic valleys and barriers across both high and low energy scales.\nTo overcome these barriers\, we propose a novel approach inspired by a completely different field: advertisement/recommendation engines (contextual Bandits) currently powering social media feeds and large parts of the Internet. By leveraging bandit strategies that balance the exploration of unknown configurations with the exploitation of known areas\, we demonstrate an efficient method for navigating this landscape. Our results show that these strategies successfully identify the lowest energy states where traditional methods often fail\, providing a robust framework for predicting and engineering the properties of strongly correlated magnetic materials. \n[1] Ponet\, L.\, Di Lucente\, E.\, & Marzari\, N. (2024). The energy landscape of magnetic materials. npj Computational Materials\, 10(1)\, 151.\n[2] Haddadi\, F.\, Campi\, D.\, dos Santos\, F.\, Mounet\, N.\, Ponet\, L.\, Marzari\, N.\, & Gibertini\, M. (2025). Exploring the magnetic landscape of easily-exfoliable two-dimensional materials (arXiv:2509.09531v2). \n_ \nContact : matteo.dastuto@neel.cnrs.fr
URL:https://sfp-alpes.fr/event/alberto-carta-laboratory-for-material-simulations-paul-scherrer-institut-villigen/
LOCATION:CNRS – Salle Louis Weil (E424)\, CNRS - Institut Néel 25 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260915T110000
DTEND;TZID=Europe/Paris:20260915T120000
DTSTAMP:20260910T142118Z
CREATED:20260910T142118Z
LAST-MODIFIED:20260910T142118Z
UID:10000243-1789470000-1789473600@sfp-alpes.fr
SUMMARY:Thomas KISBY (Centre for Nanotechnology in Medicine\, Manchester (UK)
DESCRIPTION:Nanoscale approaches to brain tumour therapy : harnessing biology for targeted therapeutics\nRésumé : \nGlioblastoma remains one of the most challenging cancers to treat\, in part because conventional approaches struggle to selectively access and target the cells responsible for recurrence. This talk will explore how nanoscale technologies can exploit the biology of brain tumours and the brain to create new therapeutic opportunities. Using graphene oxide\, a nanomaterial with preferential interaction with tumour-associated immune cells\, I will describe how we can use this as a locally administered platform for both more localised chemotherapy and targeted tumour immunomodulation. \nI will then discuss a new approach that exploits the biological response to tumour resection itself : a transient postoperative window in which the blood–brain barrier becomes selectively\npermeable to clinically used liposomal nanomedicines. By linking the timing and biology of surgery with nanoscale drug delivery\, we have developed an approach to specifically target residual disease at the site of recurrence. Together\, these studies illustrate how understanding and exploiting biological processes can guide the design and application of nanotherapeutics for brain cancer. \n_ \nContact : anne-laure.bulin@univ-grenoble-aleps.fr
URL:https://sfp-alpes.fr/event/thomas-kisby-centre-for-nanotechnology-in-medicine-manchester-uk/
LOCATION:IAB – Salle de séminaire\, IAB Site Santé - Allée des Alpes\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IAB":MAILTO:appaixfl@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260918T100000
DTEND;TZID=Europe/Paris:20260918T110000
DTSTAMP:20260828T133335Z
CREATED:20260828T133107Z
LAST-MODIFIED:20260828T133335Z
UID:10000233-1789725600-1789729200@sfp-alpes.fr
SUMMARY:Sandrine GERBER (Deputy Director of the Institute of Chemical Sciences and Engineering (ISIC) at EPFL) -  Franck LEBRIN (PhD​ Director of an international Inserm JointLab at Leiden University Medical Center​ (LUMC\, Department of Internal Medicine))
DESCRIPTION:1) Multifunctional harmonic nanoparticles for targeted bioimaging and drug delivery.\n\n\n​​​​​​​2) Targeting pericytes for microvascular stabilization.\nRésumé : \n\nSandrine GERBER\nIs e​xpert in organic synthesis\, engineering of polymer and lipid-based nanoparticles for gene delivery\, surface functionalization of nanomaterials for theranostic applications as well as DNA biosensors for viral screening.\nThe research program of her group is devoted to the development of new chemical entities for bio-applications. Her team is mainly interested in the design\, synthesis and evaluation of functionalized nanomaterials and biomaterials for therapeutic applications as imaging probes\, drug nanocarriers and biosensors. In particular\, harmonic nanoparticles are bioconjugated to cancer targeting ligands\, caged therapeutic cargos and complementary contrast agents to develop new theranostic tools. Chitosan-based copolymers are engineered for the delivery of plasmid DNA and siRNA in the context of liver metabolic diseases and oncology. The functionalization of glass slides and gold interdigitated electrodes with peptide- and polymer-based spacers is used for the development of DNA biosensors for viral screening.​\n​\nFranck LEBRIN\n​Is a vascular biologist​ and a member of Inserm Abroad. His research focuses on microvascular disorders\, particularly Hereditary Hemorrhagic Telangiectasia (HHT)\, with an emphasis on endothelial–pericyte interactions. He develops advanced human hiPSC- and mouse-based models\, combined with ultrasound imaging\, to investigate disease mechanisms and support translational research. His work has contributed to the development of AKT inhibitors currently in Phase I and III clinical trials\, as well as small molecules promoting vessel stability and integrity for HHT and pericyte-related diseases affecting the brain\, eye\, and kidney. He is Vice-Chair of Cure HHT International and founder of RougeTX\, a spin-off developing pericyte-focused therapies.​\n\n\n_\n\n\n\n\n\nATTENTION ! L’accès à Clinatec est réservé aux porteurs de laissez-passer CEA
URL:https://sfp-alpes.fr/event/sandrine-gerber-deputy-director-of-the-institute-of-chemical-sciences-and-engineering-isic-at-epfl-franck-lebrin-phd-director-of-an-international-inserm-jointlab-at-leiden-university/
LOCATION:Clinatec\, amphithéâtre\, 17\, avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260918T140000
DTEND;TZID=Europe/Paris:20260918T160000
DTSTAMP:20260703T085657Z
CREATED:20260703T085657Z
LAST-MODIFIED:20260703T085657Z
UID:10000215-1789740000-1789747200@sfp-alpes.fr
SUMMARY:Soutenance de thèse par Mélanie LOPES (CEA-Irig/BGE)
DESCRIPTION:Vascularisation d’ilots pancréatiques sur puce microfluidique pour le suivi du diabète de type 1\nRésumé : \nLe diabète de type 1 est une maladie auto-immune caractérisée par la destruction des cellules βpancréatiques. Bien que la transplantation d’îlots de Langerhans puisse restaurer une sécrétion endogène d’insuline chez certains patients\, son efficacité à long terme reste limitée par la perte du greffon\, une revascularisation insuffisante\, l’hypoxie\, l’inflammation et le rejet immunitaire. Un enjeu majeur est donc de développer des modèles humains in vitro capables de reproduire le microenvironnement des îlots pancréatiques\, notamment leur niche vasculaire. \nL’objectif de cette thèse était de développer des modèles humains vascularisés et perfusables d’îlots pancréatiques compatibles sur la puce microfluidique serpentin précédemment développée. Premièrement\, des organoïdes pancréatiques multicellulaires pré-endothélialisés\, appelés Langerhanoïdes\, ont été générés à partir de cellules EndoCβH5 ou d’îlots humains dissociés\, associés à des cellules endothéliales et stromales. Leur structure 3D\, la sécrétion d’insuline\, le développement d’un réseau endothélial endothéliales avec le microenvironnement et la perfusion sur la puce microfluidique serpentin ont été évalués. Concernant les Langerhanoïdes\, les résultats ont montré que l’identité et la proportion des cellules stromales influençait fortement la compaction des Langerhanoïdes et l’intégration des cellules endothéliales. \nDans un deuxième temps\, un gel à base de lysat plaquettaire humain (hPLG) a été développé afin de fournir un microenvironnement bioactif\, sans composant xénogénique\, capable de soutenir le développement d’un réseau endothélial et la survie des cellules endocrine. Cependant\, les propriétés mécaniques d’hPLG a limité son utilisation sur puce. Ainsi\, un gel hybride associant lysat plaquettaire humain et fibrine humaine a donc été développé afin d’améliorer les propriétés mécaniques du gel en conservant ses propriétés pro-angiogéniques et cytoprotectrices. \nCe travail met en évidence le potentiel\, mais aussi les défis\, associés au développement de modèles pancréatiques perfusables. La formation d’un réseau endothélial a été obtenu\, mais la perfusion intratissulaire reste dépendante de la composition cellulaire\, des propriétés mécaniques des gels et du design de la puce. Ces modèles sont prometteurs pour étudier les interactions endocrines–vasculaires\, le recrutement immunitaire\, les réponses aux traitements\, la transplantation d’îlots et la médecine personnalisée dans le diabète de type 1​. ​​​​ \n  \n\n\nATTENTION ! L’entrée du site CEA-Grenoble nécessite une autorisation préalable et sur présentation de votre pièce d’identité le jour de votre venue (CI ou passeport\, car le permis de conduire n’est pas recevable). Veuillez impérat​ivement nous contacter par mail avant le 04 septembre : envoyer un mail
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-melanie-lopes-cea-irig-bge/
LOCATION:CEA – Salle de Séminaire IRIG (1005 – 445)\, 17\, avenue des Martyrs\, Grenoble\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260923T140000
DTEND;TZID=Europe/Paris:20260923T160000
DTSTAMP:20260827T154932Z
CREATED:20260827T154932Z
LAST-MODIFIED:20260827T154932Z
UID:10000228-1790172000-1790179200@sfp-alpes.fr
SUMMARY:Soutenance de Thèse par Béatrice VIBERT (CEA-Irig/IBS)
DESCRIPTION:Design of innovative tools for the NMR studies of glycosylated therapeutic antibodies at atomic resolution \nRésumé : \n\nThanks to their high specificity and the few associated side effects\, monoclonal antibodies are excellent candidates for the treatment of numerous diseases including cancers\, infectious diseases\, and neurodegenerative disorders. This class of biopharmaceuticals has expanded considerably in recent years and now represents an increasingly important proportion of approved therapeutic molecules. Monoclonal antibodies must undergo extensive quality controls throughout their development before going on the market\, and new techniques are required to reliably and precisely characterize these emerging biopharmaceuticals. In particular\, knowing the three-dimensional structure of these proteins is essential to ensure their efficacy and safety. The structure of therapeutic antibodies can be affected at different development stages by changes in the production protocol\, the formulation buffer\, or the storage conditions. It is also critical to detect any structural modification between two production batches. However\, the methods routinely used today in the pharmaceutical industry do not provide detailed information about the structure of antibodies in solution. Nuclear magnetic resonance (NMR) spectroscopy is a technique capable of delivering structural information at atomic resolution. Although biomolecular NMR has long been limited to the study of low-molecular-weight proteins\, methyl-based NMR has recently emerged as a powerful tool for monitoring the structure of therapeutic antibodies under formulation conditions. Nevertheless\, significant methodological developments are still required to make NMR a quality-control tool capable of translating each observed spectral change into the localisation of impacted residues. \n​The work presented in this thesis manuscript focuses on developing innovative tools to precisely characterize therapeutic antibodies in solution using NMR. To simplify spectrum analysis and mprove their quality\, the crystallizable fragment (Fc) and the antigen-binding fragment (Fab) were studied separately. A first essential step in analysing these fragments by NMR is the assignment of signals to their corresponding amino acids. By combining cell-free expression of antibody fragments enriched in 2H\, 13C et 15N with high-quality NMR spectra acquisition\, nearly all signals were assigned. The main structural difference between fragments produced in a cell-free system and therapeutic antibodies produced in mammalian cells is the presence of glycans at asparagine 297 of the Fc fragment\, which induces changes in biological activity. Faced with the impossibility of implementing a technique of enzymatic glycosylation of the Fc fragment produced in a cell-free system\, isotopically enriched antibodies produced in eukaryotic cells were employed. Thus\, the spectrum of a glycosylated Fc was assigned by comparison with that of the non-glycosylated Fc. By combining these results with the work performed on the Fab fragment of the anti-LAMP1 antibody\, the methyl groups resonances of the full antibody could be assigned. A method was also developped to accelerate methyl resonance assignment of IgG1 Fab fragments. This work therefore transformed methyl-based NMR into a tool capable of locating any structural modification of an antibody by overlaying simple 2D spectra acquired under formulation conditions. This tool made it possible to characterize the structural impact of glycosylation\, of methionine oxidation in the Fc\, of Fab interaction with its antigen\, as well as the dynamics of a full antibody and its fragments​.\n_ \n\n\n\n\nLes séminaires et soutenances sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire  et de l’adresser\, plus de 48h à l’avance\, à ce contact.\nPensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-beatrice-vibert-cea-irig-ibs/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260924T113000
DTEND;TZID=Europe/Paris:20260924T123000
DTSTAMP:20260917T150745Z
CREATED:20260917T150745Z
LAST-MODIFIED:20260917T150745Z
UID:10000258-1790249400-1790253000@sfp-alpes.fr
SUMMARY:Jérémie POSCHMANN (Université de Nantes)
DESCRIPTION:Functional genomics of brain disease : linking regulatory mechanisms\, circulating immune states and clinical trajectories\nRésumé : \nMy research uses func-onal genomics to characterize disease associated molecular states and to understand how they relate to biological mechanisms\, clinical heterogeneity and patient trajectories. I first used functional genomics directly in human brain tissue to identify regulatory alterations associated with disease. In autism spectrum disorder\, genome wide profiling revealed that clinically and genetically heterogeneous patients nevertheless shared convergent changes in regulatory activity. Subsequent studies in other brain disorders showed that this convergence at the molecular level was a recurrent feature and established functional genomics as a powerful approach to resolve disease-associated regulatory states. I subsequently extended this approach to circulating cells\, with the objective of accessing disease associated molecular states in living patients. In severe brain injury and psychiatric disorders\, our studies identified\nimmune and regulatory signatures associated with clinical trajectories and disease severity. These results support the use of circulating immune states to characterize biological heterogeneity beyond conventional diagnostic categories and provide a basis for patient stratification. A complementary programme in genetically defined neurodevelopmental disorders allows us to investigate these molecular alterations in a causal framework. By profiling patient blood cells carrying pathogenic variants in chromatin and proteostasis regulators\, we can connect a defined genetic alteration to its molecular consequences and to disease-relevant cellular pathways. \nTogether\, these studies establish a func-onal genomics framework that links regulatory mechanisms to accessible biomarkers and clinical trajectories in neurological and psychiatric disease. \n_ \nContact : yury.lages@univ-grenoble-alpes.fr ou sebastien.carnicella@univ-grenoble-alpes.fr \n 
URL:https://sfp-alpes.fr/event/jeremie-poschmann-universite-de-nantes/
LOCATION:GIN – Amphi Serge Kampf\, Grenoble Institut des Neurosciences (GIN) Bât. Edmond J. Safra\, Chemin Fortune Ferrini CHU\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260925T093000
DTEND;TZID=Europe/Paris:20260925T113000
DTSTAMP:20260903T150140Z
CREATED:20260903T150140Z
LAST-MODIFIED:20260903T150140Z
UID:10000235-1790328600-1790335800@sfp-alpes.fr
SUMMARY:Soutenance de Thèse par Pierre GUENZI-TIBERI (CEA-Irig/LPCV)
DESCRIPTION:Génomique des algues des neiges : du génome à la cellule et aux populations\nRésumé : \nLa neige est peuplée d’organismes unicellulaires dont très peu d’espèces ont été décrites\, et aucun génome caractérisé. Au dessus de la limite de l’habitat des arbres\, les formes pionnières sont des microalgues photosynthétiques\, dont certaines peuvent devenir dominantes\, accumulant des caroténoïdes et colorant la neige en rouge. Dans le cadre du programme Alpalga​ des collectes effectuées par les laboratoires proposant ce projet\, dans la Zone Atelier Alpes réalisées de 2017 à 2022 ont permis d’isoler des espèces différentes : 4 génomes d’algues cultivables ont été séquencés\, 1 génome d’algue non cultivable est en cours de séquençage à partir de données métagénomiques et 1 champignon unicellulaire des neiges est aussi en cours de séquençage. Le projet de thèse vise donc la première caractérisation génomique de microorganismes eucaryotes peuplant la neige\, aux niveaux moléculaires\, cellulaires (génomique fonctionnelle)\, et des des populations afin de déchiffrer les mécanismes génomiques et éco-physiologiques permettant de ‘vivre dans la neige’. \nLe projet reposera sur une expertise importante de l’étudiant.e en bioinformatique/analyse de génomes (annotation\, comparaison de génomes\, métagénomique)\, nécessitant un accès à des données de génomique originales en grande partie déjà disponibles. Le projet combine donc une part à faible risque\, voire sans risque\, d’annotation et de génomique comparative. Pour le deuxième volet\, le risque sera maitrisé en se focalisant sur un nombre raisonnable d’espèces\, caractéristiques des environnements explorés.​ \n  \n\n\nTitle : Snow algae genomics: from genomes to cells and populations \nAbstract​​ : \nSnow is populated by unicellular organisms of which very few species have been described\, and no genome characterized. Above the tree line\, the pioneer forms are photosynthetic microalgae\, some of which can become dominant\, accumulating carotenoids and coloring the snow red. As part of the Alpalga program collections carried out by the laboratories proposing this project\, in the Zone Atelier Alpes carried out from 2017 to 2022\, made it possible to isolate different species: 4 genomes of culturable algae have been sequenced\, 1 non-culturable algal genome is being sequenced from metagenomic data and 1 unicellular snow fungus is also being sequenced. The thesis project therefore aims for the first genomic characterization of eukaryotic microorganisms populating the snow\, at the molecular\, cellular (functional genomics)\, and population levels in order to decipher the genomic and eco-physiological mechanisms allowing ‘living in the snow’.\nThe project will be based on the student’s significant expertise in bioinformatics/genome analysis (annotation\, genome comparison\, metagenomics)\, requiring access to original genomic data that is largely already available. The project therefore combines a low-risk\, or even no-risk\, part of annotation and comparative genomics. For the second part\, the risk will be controlled by focusing on a reasonable number of species\, characteristic of the environments explored.\n_ \n\n\n\n\n\nATTENTION ! L’entrée d​u site CEA-Grenoble nécessite une autorisation préalable et sur présentation de votre pièce d’identité le jour de votre venue (CI ou passeport\, car le permis de conduire n’est pas recevable). Veuillez impérat​ivement nous contacter par mail avant le 19​ septembre : envoyer un mail \nNote : Entry to the CEA-Grenoble site requires prior authorization and the presentation of your ID on the day of your visit (ID card or passport; driver’s licenses are not accepted). Please request this authorization before September 19th to send an e-mail​
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-pierre-guenzi-tiberi-cea-irig-lpcv/
LOCATION:CEA Grenoble – Amphi Dautreppe\, 17\, avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260925T110000
DTEND;TZID=Europe/Paris:20260925T120000
DTSTAMP:20260827T154550Z
CREATED:20260827T154550Z
LAST-MODIFIED:20260827T154550Z
UID:10000227-1790334000-1790337600@sfp-alpes.fr
SUMMARY:Toyoyuki OSE (Hokkaido University\, Japon​)
DESCRIPTION:Viral strategies for immune evasion targeting the JAK-STAT pathway\nRésumé : \n\nThe capacity of viruses to target and inhibit immune signaling by the principal antiviral cytokines\, interferons (IFNs)\, is critical to the outcomes of infection and disease\, and is mediated by viral IFN-antagonist proteins. We have been working on viral IFN-antagonists from the order Mononegavirales such as genus Lyssavirus (e.g.\, rabies virus) and Morbillivirus (e.g.\, measles virus) that counteract the JAK-STAT system. STAT family members mediate signaling in the JAK–STAT pathway and are activated by phosphorylation at a conserved tyrosine residue\, resulting in dimerization through reciprocal interactions between the phosphotyrosine and a SH2 domain.\nTyrosine-phosphorylated STAT (pY-STAT) then translocates to the nucleus to induce the expression of genes encoding antiviral proteins. Although the active and functional forms of STATs are conventionally considered to be dimers\, STATs can undergo higher-order oligomerization\, which is implicated in regulating transcriptional activity. \nWe presented the cryo-EM structures of the tetrameric form of intact pY-STAT1 in complex with DNA or the P protein of rabies viruses [1\,2]. We explained the molecular architecture of the interactions by which P protein selectively antagonizes phosphorylated\, activated STAT1. This novel binding mode explains previously undefined mechanisms by which P protein inhibits importin binding\, DNA binding\, and the conformational transition of activated STAT1 into its DNA-binding form\, thus efficiently shutting down antiviral signaling. We also clarified that the C-terminal domain of the V protein from measles virus selectively binds to the core-region of STAT2 but not STAT13. We were able to monitor that binding of V and IRF9 to STAT2-core is competitive ; V disrupts a preformed STAT2–IRF9 interaction\, suggesting a new mechanism by which V can prevent type I IFN signaling by preventing STAT1–STAT2–IRF9 (the ISGF3 complex) formation [3\,4]. Taken together\, our findings substantially advance molecular understanding of viral evasion of antiviral immunity\, with high resolution molecular insights having the potential to inform novel intervention strategies for a lethal viral disease. \n1. Rabies virus antagonizes interferon signaling by targeting phosphorylated STAT1 tetramers. bioRxiv 2026.07.29.741124 (2026) doi:10.64898/2026.07.29.741124.\n2. Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein. Sci. Signal. 18\, eads2210 (2025).\n3. The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9. J. Virol. 94\, e01169-20 (2020).\n4. Solution structure of the C-terminal domain of the measles virus V protein in its free form and mechanistic analysis of STAT2 targeting. J. Virol. 99\, e00739-25 (2025).​ \n_\n\n\n\n\nLes séminaires et soutenances sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire  et de l’adresser\, plus de 48h à l’avance\, à ce contact.\nPensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/toyoyuki-ose-hokkaido-university-japon/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260925T140000
DTEND;TZID=Europe/Paris:20260925T160000
DTSTAMP:20260917T143353Z
CREATED:20260827T160938Z
LAST-MODIFIED:20260917T143353Z
UID:10000230-1790344800-1790352000@sfp-alpes.fr
SUMMARY:ATTENTION !!! Changement de salle !!! - Soutenance de Thèse par Chalimar SALAMEH (CEA-Irig/SyMMES)
DESCRIPTION:Développement de biocapteurs interférométriques multiplexés sur fibres optiques pour le diagnostic moléculaire in vivo\nRésumé : \nLe diagnostic médical est un processus complexe et itératif\, souvent dépendant de biopsies invasives qui comportent des risques de complications et des délais dans l’obtention des résultats. Pour passer de biopsies ex situ à des biopsies in situ\, ce projet s’appuie sur la technologie de laboratoire sur fibre afin de développer une plateforme de diagnostic peu invasive. Le dispositif proposé consiste en une fibre optique flexible à 12 cœurs recouverte de deux couches minces : une couche semi-réfléchissante de Ta2O5 et une cavité optique en SiO2. Ces couches transforment la fibre en un capteur interférométrique. En immobilisant une couche biologique de biosondes sur la surface\, le dispositif est converti en un biocapteur capable d’interagir avec les analytes cibles dans l’environnement étudié. \nLa réponse optique du dispositif a été modélisée en utilisant la Méthode des Matrices de Transfert sous Python. Les variations de l’indice de réfraction du milieu environnant modifient l’intensité globale de la réflectivité en fonction de la longueur d’onde\, définissant la sensibilité en volume près du bout de la fibre. À l’inverse\, la sensibilité en surface est évaluée par l’ajout d’une biocouche et l’augmentation de son épaisseur\, ce qui simule la liaison d’analytes. Cet accroissement du chemin optique induit un décalage mesurable du spectre de réflectivité. Le modèle numérique démontre la capacité du biocapteur à découpler les sensibilités en volume et en surface en ajustant simplement la longueur d’onde de travail. \nAfin de caractériser la sensibilité et la résolution du capteur\, un montage optique basé sur un éclairage de Köhler en mode réflexion a été conçu. Un filtre angulaire supprime la réflexion spéculaire sur la face avant de la fibre\, permettant une interrogation en intensité à des longueurs d’onde discrètes dans le spectre visible. La validation expérimentale utilisant différentes concentrations de glycérol a montré un fort accord avec les simulations numériques : les courbes et les signes de sensibilité de volume se correspondent pour différentes combinaisons de couches interférométriques. La sensibilité la plus élevée atteinte se situe autour de 800%/RIU\, avec une résolution de l’ordre de 10-4 RIU. \nDe plus\, la sensibilité en surface\, évaluée au moyen d’une technique de dépôt de polyélectrolytes couche par couche et en considérant une épaisseur de bicouche hydratée entre 5 et 10 nm\, a été comprise entre 0\,13 et 9\,05 %/nm selon l’échantillon et le cœur. En s’appuyant sur ces résultats\, diverses stratégies de fonctionnalisation ont été développées pour convertir le capteur physique en biocapteur\, allant de modifications homogènes à des modifications localisées. Pour ces dernières\, un montage optique UV a été construit pour balayer et illuminer des régions d’intérêt spécifiques sur la surface de la fibre. En utilisant un agent de liaison photosensible\, la NHS-diazirine\, l’immobilisation et l’hybridation localisées d’oligonucléotides ont été réalisées avec succès sur de multiples substrats : lames de verre\, conduits d’image\, assemblages de fibres à 6000 cœurs et la fibre optique à 12 cœurs. Ces résultats ont été validés soit par imagerie de fluorescence\, soit par un suivi en temps réel des interactions biomoléculaires en solution tampon\, via la mesure de l’intensité lumineuse moyenne retro-réfléchie par les cœurs de la fibre. En particulier\, l’hybridation des oligonucléotides a entraîné une augmentation de 0.75 à 1% du signal normalisé\, suivie d’une amplification de 2.5% lors de l’injection de streptavidine. Toutes ces avancées ouvrent la voie à des diagnostics in vivo multiplexés.​​​​​ \n_ \nATTENTION ! L’entrée du site CEA-Grenoble nécessite une autorisation préalable et sur présentation de votre pièce d’identité le jour de votre venue (CI ou passeport\, car le permis de conduire n’est pas recevable). Veuillez impérat​ivement nous contacter par mail avant le 14 septembre : envoyer un mail \n\n\nNote : Entry to the CEA-Grenoble site requires prior authorization and the presentation of your ID on the day of your visit (ID card or passport; driver’s licenses are not accepted). Please request this authorization before September 14th to send an e-mail​
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-chalimar-salameh-cea-irig-symmes/
LOCATION:CEA-Grenoble\, Bâtiment YSpot\, Plateau de la création (Rdc)\, 17\, avenue des Martyrs\, Grenoble\, 38000\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260929T140000
DTEND;TZID=Europe/Paris:20260929T150000
DTSTAMP:20260910T152942Z
CREATED:20260910T152942Z
LAST-MODIFIED:20260910T152942Z
UID:10000248-1790690400-1790694000@sfp-alpes.fr
SUMMARY:Natali PLANK (School of Chemical and Physical Sciences and the MacDiarmid Institute for Advanced Materials and Nanotechnology\, Victoria University of Wellington\, New Zealand)
DESCRIPTION:Nanowire and carbon nanotube device structures for Biosensors and Artificial Neural Networks\nRésumé : \nCarbon nanotube (CNT) networks offer a particularly attractive platform due to their simple fabrication\, tunable electronic properties\, and ability to be interrogated through multiple electrical contacts on a single chip [1]. Functionalised carbon nanotube and graphene field effect transistors (CNTFETs and GFETs) have been used as the active channel in biosensors\, with the future promise of lab-on-a-chip diagnostics strongly motivating the research [2]. The ability to effectively sense analytes depends on multiple factors\, the conductivity of the platform [3]\, the robustness of the functionalisation and the selectivity and function of the receptor [4]. \nCarbon nanotubes also offer an interesting base platform for neuromorphic computing via physical reservoirs. Physical reservoir computing exploits the intrinsic dynamics of complex materials to perform temporal information processing with low power consumption and minimal training requirements. Disordered networks of memristive nanowires have emerged as promising neuromorphic architectures\, as they can host large numbers of nonlinear junctions that collectively generate rich spatiotemporal dynamics [5-7]. \nHere I will present our recent work on the development of the CNTFET and GFET platforms with aptamers and insect odorant receptors and the different challenges and device constraints we have encountered. I will also present our work on the development of the CNT platform for physical reservoir computing applications. \n[1]      Topinka\, M. A\, et al. Nano Lett. 2009 9\, 1866–1871 \n[2]      T An et al\, Lab Chip\, 2010\,10\,2052-2056 \n[3]      M Thanihaichelvan M\, et al\, Biosensors and Bioelectronics\, 2019\, 130\, 408-413 \n[4]      Nguyen et al.\, Nanomaterials\, 2021 11 (9)\, 2280 \n[5]      Milano\, G\, et al. Nat. Mater. 2022\, 21 (2)\, 195–202. \n[6]      Kotooka\, T.\, et al. Thermally Stable Ag 2 Se Nanowire Network as an Effective In-Materio Physical Reservoir Computing Device. 2024\, 2400443\, 1–10.  \n[7]      Zhu\, R.\, et al Online Dynamical Learning and Sequence Memory with Neuromorphic Nanowire Networks. Nat. Commun. 2023\, 14 (1)\, 6697.  \n\nShort Bio/CV\nDr Natalie Plank is Deputy Director for Commercialisation and Industry Engagement and an Associate Professor in Physics in the School of Chemical and Physical Sciences at Victoria University of Wellington. Natalie completed a BSc (Hons) in Astrophysics at The University of Edinburgh before doing an MSc in Microelectronics. She then completed her PhD on the functionalisation of carbon nanotubes for molecular electronics with Rebecca Cheung also at The University of Edinburgh. \nNatalie’s research interests are in the area of nanomaterial device fabrication and the characterisation of novel materials. Her current work focuses on nanomaterial device platforms for sensing technology and artificial neural networks. She is interested in carbon nanotubes and ZnO nanowires for nanowire transistor applications and in particular the ability to functionalise the nanomaterial channels with specific biomarkers or memristive molecules. Natalie’s core interests are in low cost fabrication techniques which allow for high throughput of devices whilst maintaining the particular material properties of the unique nanowire system. \n_ \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/natali-plank-school-of-chemical-and-physical-sciences-and-the-macdiarmid-institute-for-advanced-materials-and-nanotechnology-victoria-university-of-wellington-new-zealand/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260929T140000
DTEND;TZID=Europe/Paris:20260929T160000
DTSTAMP:20260827T161753Z
CREATED:20260827T161753Z
LAST-MODIFIED:20260827T161753Z
UID:10000231-1790690400-1790697600@sfp-alpes.fr
SUMMARY:Soutenance de Thèse par Léa VALET (CEA-Irig/Biosanté)
DESCRIPTION:Rôles respectifs de Bone Morphogenetic Protein 10 (BMP10) cardiaque et hépatique dans le système cardiovasculaire\nRésumé : \nL’Activin receptor-like kinase 1 (ALK1) est un récepteur principalement exprimé par les cellules endothéliales\, et les mutations perte de fonction de son gène\, ACVRL1\, sont responsables de la télangiectasie hémorragique héréditaire (HHT) aussi appelée maladie de Rendu-Osler\, une pathologie rare caractérisée par de multiples anomalies vasculaires. Ses ligands de haute affinité\, Bone Morphogenetic Protein 9 (BMP9) et Bone Morphogenetic Protein 10 (BMP10)\, jouent un rôle central dans le maintien de l’homéostasie vasculaire. BMP9 est produit par les cellules étoilées du foie\, tandis que BMP10 est classiquement décrit comme étant majoritairement synthétisé par les cardiomyocytes de l’oreillette droite. Toutefois\, des travaux récents ont mis en évidence une production de BMP10 par les cellules étoilées du foie\, remettant en question cette vision classique et suggérant l’existence d’une source hépatique jusqu’alors largement sous-estimée. Cette observation soulève une question fondamentale : quelle est l’origine du BMP10 circulant biologiquement actif et quelle est la contribution respective du cœur et du foie au maintien de l’homéostasie vasculaire dépendante d’ALK1 ? \nPour répondre à cette question\, nous avons développé de nouveaux modèles murins permettant une délétion tissu-spécifique de Bmp10 : une délétion inductible dans les cardiomyocytes et une délétion constitutive dans les cellules étoilées du foie. Ces modèles ont été croisés avec des souris invalidées pour Bmp9 afin d’analyser les conséquences vasculaires de la perte combinée des différents ligands capables d’activer ALK1. Après validation génétique de ces modèles\, nous avons cherché à identifier l’origine du BMP10 circulant biologiquement actif et à caractériser les conséquences physiopathologiques associées à la perte de ces deux ligands. \nDe manière surprenante\, nos résultats révèlent que la délétion de Bmp10 dans le foie entraîne une disparition complète du BMP10 circulant biologiquement actif\, tandis que sa délétion cardiaque n’altère ni sa concentration plasmatique ni son activité biologique. Ces données démontrent ainsi que\, contrairement à ce qui était admis jusqu’à présent\, le foie\, et non le cœur\, constitue la principale source de BMP10 circulant actif. Sur le plan phénotypique\, les souris déficientes pour Bmp9 et Bmp10 hépatique présentent d’importantes altérations vasculaires locales : perte de l’identité endothéliale des sinusoïdes hépatiques associée à une dérégulation de voies métaboliques et à une accumulation de fibres de collagène dans le foie. De façon remarquable\, ces altérations ne se limitent pas au foie mais s’accompagnent d’une atteinte vasculaire systémique\, caractérisée par l’apparition d’anomalies artérioveineuses au niveau intestinal et rénal. Nous mettons également en évidence une atteinte pulmonaire sévère associée à une dilatation marquée des capillaires pulmonaires\, une désorganisation profonde du parenchyme pulmonaire ainsi qu’une augmentation importante de la perméabilité vasculaire. À l’inverse\, aucun de ces phénotypes n’est observé lors de la délétion combinée de Bmp9 et de Bmp10 cardiaque. \nCe travail révèle ainsi un rôle jusqu’alors insoupçonné du foie comme source principale de BMP10 circulant actif. En association avec BMP9\, ce ligand apparaît indispensable au maintien de l’intégrité endothéliale et de l’homéostasie vasculaire. Ces résultats redéfinissent notre compréhension des mécanismes contrôlant l’activation endothéliale d’ALK1 in vivo et apportent un nouvel éclairage sur les mécanismes impliqués dans les pathologies vasculaires associées à cette voie de signalisation\, notamment la maladie de Rendu-Osler. ​ ​​​​ \n\n\n_ \nTitle : The Respective Roles of Cardiac and Hepatic Bone Morphogenetic Protein 10 (BMP10) in the Cardiovascular System \nAbstract​​ : \nActivin receptor-like kinase 1 (ALK1) is a receptor predominantly expressed by endothelial cells\, and loss-of-function mutations in its encoding gene\, ACVRL1\, are responsible for hereditary hemorrhagic telangiectasia (HHT)\, also known as Rendu-Osler disease\, a rare vascular disorder characterized by multiple vascular abnormalities. Its high-affinity ligands\, Bone Morphogenetic Protein 9 (BMP9) and Bone Morphogenetic Protein 10 (BMP10)\, play a central role in maintaining vascular homeostasis. BMP9 is produced by hepatic stellate cells\, whereas BMP10 is essentially described as synthesized by right atrial cardiomyocytes. However\, recent studies have demonstrated BMP10 production by hepatic stellate cells\, challenging this classical view and suggesting the existence of a previously underevaluated hepatic source. This observation raises a fundamental question: what is the origin of biologically active circulating BMP10\, and what are the respective contributions of the heart and the liver to ALK1-dependent vascular homeostasis? \nTo address this question\, we developed novel mouse models allowing tissue-specific deletion of Bmp10\, including an inducible cardiomyocyte-specific knockout and a constitutive hepatic stellate cell-specific knockout (KO). These models were crossed with Bmp9-KO mice to investigate the vascular consequences of the combined loss of the different ligands capable of activating ALK1. Following genetic validation of these models\, we sought to identify the origin of biologically active circulating BMP10 and to characterize the pathophysiological consequences associated with the loss of these two ligands. \nStrikingly\, our results demonstrate that hepatic deletion of Bmp10 leads to the complete loss of biologically active circulating BMP10\, whereas cardiac deletion does not affect either its plasma concentration or its biological activity. These findings demonstrate that\, contrary to the current view\, the liver\, rather than the heart\, is the primary source of biologically active circulating BMP10. Phenotypically\, mice deficient in Bmp9 and hepatic Bmp10 display major local vascular alterations associated with disruption of liver sinusoidal endothelial identity\, dysregulation of hepatic metabolic pathways\, and collagen deposition in the liver. Remarkably\, these alterations are not restricted to the liver but are accompanied by systemic vascular defects\, including the development of arteriovenous abnormalities in the intestine and kidneys. We also demonstrate severe pulmonary alterations characterized by marked dilation of pulmonary capillaries\, profound disruption of lung parenchymal architecture\, and a substantial increase in vascular permeability. In contrast\, none of these phenotypes are observed following the combined deletion of Bmp9 and cardiac Bmp10. \nOverall\, this work uncovers a previously unrecognized role of the liver as the principal source of biologically active circulating BMP10. Together with BMP9\, this ligand is essential for maintaining endothelial integrity and vascular homeostasis. These findings redefine our understanding of the mechanisms governing endothelial ALK1 activation in vivo and provide new insights into the mechanisms underlying vascular diseases associated with this signaling pathway\, particularly hereditary hemorrhagic telangiectasia. \n_ \nATTENTION ! L’entrée d​u site CEA-Grenoble nécessite une autorisation préalable et sur présentation de votre pièce d’identité le jour de votre venue (CI ou passeport\, car le permis de conduire n’est pas recevable). Veuillez impérat​ivement nous contacter par mail avant le 19​ septembre : envoyer un mail \n\n\n\n\nNote : Entry to the CEA-Grenoble site requires prior authorization and the presentation of your ID on the day of your visit (ID card or passport; driver’s licenses are not accepted). Please request this authorization before September 19th to send an e-mail​
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-lea-valet-cea-irig-biosante/
LOCATION:CEA – Salle de Séminaire IRIG (1005 – 445)\, 17\, avenue des Martyrs\, Grenoble\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261001T130000
DTEND;TZID=Europe/Paris:20261001T140000
DTSTAMP:20260917T134744Z
CREATED:20260917T134744Z
LAST-MODIFIED:20260917T134744Z
UID:10000255-1790859600-1790863200@sfp-alpes.fr
SUMMARY:Alice CLEYNEN (LJK\, Grenoble)
DESCRIPTION:Les différentes facettes de l’ARN : les opportunités ouvertes par le séquençage direct par nanopore\nRésumé : \nLe séquençage direct de l’ARN (Direct RNA Sequencing\, DRS) par nanopore (Oxford Nanopore Technologies) est une technologie qui lit les molécules d’ARN telles qu’elles existent dans la cellule\, sans jamais les copier. Cette absence d’amplification change la donne à plusieurs titres : elle évite les biais d’estimation de l’abondance des ARN inhérents à toute étape de PCR\, et surtout elle préserve les modifications chimiques qui décorent nativement les molécules — des marques aujourd’hui reconnues comme un véritable langage réactionnel. Autre atout\, les lectures produites (des « long-reads ») couvrent la molécule dans son intégralité\, ce qui permet d’assigner directement chaque lecture à un isoforme\, plutôt que de devoir les reconstruire a posteriori à partir de données au niveau du gène. Cerise sur le gâteau\, le DRS donne aussi accès à la longueur de la queue poly(A)\, dont un nombre croissant d’études souligne le rôle déterminant dans la stabilité et la traduction des ARN. \n_ \nContact : lucie.lamothe@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/alice-cleynen-ljk-grenoble/
LOCATION:IMAG – Salle de Réunion\, 150 place du Torrent\, St Martin d’Hères\, 38400\, France
CATEGORIES:Séminaire
ORGANIZER;CN="TIMC - IMAG":MAILTO:lucie.lamothe@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261001T140000
DTEND;TZID=Europe/Paris:20261001T150000
DTSTAMP:20260911T092949Z
CREATED:20260911T092949Z
LAST-MODIFIED:20260911T092949Z
UID:10000250-1790863200-1790866800@sfp-alpes.fr
SUMMARY:Zacharias AMARA (Conservatoire National des Arts et Métiers\, Paris)
DESCRIPTION:From Interface Engineering to Wavelength Control: Selective Photocatalytic Oxidations\nRésumé : \nIn this research seminar\, we present our group’s recent advances in the development of heterogenized photocatalytic systems for selective oxidation reactions. Central to our approach is the creation of well-defined catalytic interfaces through simple and scalable heterogenization strategies\, enabling the use of green solvents while simultaneously enhancing catalyst reactivity\, robustness\, and long-term stability. These engineered interfaces provide a versatile platform for efficient photo-oxidation under mild and sustainable reaction conditions. \nBeyond catalyst design\, control over interfacial phenomena is extended to the reactor level through the implementation of continuous-flow processing. Flow photoreactors offer precise control over mass and heat transfer\, as well as improved photon management\, allowing these heterogenized systems to operate at significantly higher space–time yields. As a result\, photo-\noxidation reactions can be performed with unprecedented productivity\, reproducibility\, and scalability. \nFinally\, an additional level of control is achieved by tuning the excitation wavelength across the visible spectrum and toward lower-energy photons in the near-infrared (NIR) region. Access to wavelength-selective photoactivation enables new photo-oxygenation pathways and unlocks levels of chemoselectivity that are inaccessible under conventional higher-energy irradiation. Together\, the combined control of catalytic interfaces\, reactor architecture\, and light energy establishes a unified strategy for highly selective and efficient photocatalytic oxidation processes. \nFor key references from our group\, see: a) Amara\, Zimberlin\, Atakpa\, Al Ayi\, Lancel\, ACS Inorg. Org. Chem. Au\, 2026\, 6\, 8–22 ; b) Al Ayi\, Atakpa\, Arab\, Lancel\, Amara\, Eur. J. Org. Chem.\, 2024 e202400634 ; c) Lancel\, Lindgren\, Monnereau\, Amara\, Photochem. Photobiol. Sci. 2023\, 23\, 79-92 ; d) Lancel\, Golisano\, Monnereau\, Gomez\, Port\, Amara\, ACS Sustain. Chem. Eng. 2023\, 11\, 15674–15684 ; e) Lancel\, Zimberlin\, Gomez\, Port\, Khrouz\, Monnereau\, Amara J. Org. Chem. 2023\, 88\, 10\, 6498–6508; f) Terra\, Desgranges\, Amara\, Moores\, Catalysis Today\, 2023\, 407\, 52-58 ; g) Lancel\, Gomez\, Port\, Amara\, Front. Chem. Eng.\, 2021\, 3\, 752364. ; h) Gellé\, Price\, Voisard\, Brodusch\, Gauvin\, Amara\, Moores\, ACS Appl. Mater. Interfaces\, 2021\, 13\, 35606-35616 ; i) Blanchard\, Asbai\, Cottet\, Boissonnat\, Port\, Amara\, Org. Process Res. Dev.\, 2020\, 24\, 822-826 ; j) Tambosco\, Segura\, Seyrig\, Cabrera\, Port\, Ferroud\, Amara\, ACS Catal. 2018\, 8\, 4383-4389 \n_ \nContact : adrien.quintard@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/zacharias-amara-conservatoire-national-des-arts-et-metiers-paris/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261015T140000
DTEND;TZID=Europe/Paris:20261015T150000
DTSTAMP:20260911T130347Z
CREATED:20260911T130150Z
LAST-MODIFIED:20260911T130347Z
UID:10000251-1792072800-1792076400@sfp-alpes.fr
SUMMARY:Elise DUMONT (Institut de Chimie de Nice\, Université Côte d’Azur)
DESCRIPTION:Modeling the dynamics of DNA (photo)lesions: from reactivity to repair\nRésumé : \nFormation and repair of DNA lesions embrace a rich and combinatorial chemistry\, where atomic-scale simulations are increasingly helpful to complement and extent experimental evidences. \nThe modeling of DNA structure\, dynamics\, and (photo)chemistry has benefited from a series of recent methodological developments that now allow\, for instance capturing DNA-photosensitizers interactions\, probing new excited-state mechanisms for DNA lesions induction or photostability [1]\, and rationalize the photochemistry or photocatalytic properties of drugs within DNA owing to hybrid QM/MM-MD schemes. \nI will present a series of examples where computational approaches can palliate\, at least partly\, the absence of NMR\, FRET or X-ray data for damaged DNA oligonucleotides\, DNA-drug\nbinding modes or even DNA-proteins interactions at the nucleosomal scale [2\,3]. I will also situate DNA-ligand interactions\, which can be helpful for the design of next-generation G-\nquadruplex-specific photosensitizers [4] or new DNA-inspired photocatalysts [5]. \n[1] A. Frances-Monerris\, H. Gattuso\, D. Roca-Sanjuan\, I. Tunon\, M. Marazzi\, E. Dumont\, A. Monari\, Chem. Sci.\, 2018\, 9:7902-7911\n[2] E. Matouskova\, E. Bignon\, V. E. P. Claerbout\, T. Drsata\, N. Gillet\, A. Monari. E. Dumont\, F. Lankas\, J. Chem. Theory. Comput.\, 2020\, 16(9):5972-5981\n[3] T. Wen\, M. Kermarrec\, E. Dumont\, N. Gillet\, M. M. Greenberg\, J. Am. Chem. Soc.\, 2023\, 145(43):23702-23714\n[4] M. Deiana et al.\, Nucl. Acids. Res.\, 2023\, 51(12):6264-6285\n[5] Z. Pastorel\, J. Zani\, M. Noël\, A. Bartocci\, S. Arseniyadis\, E. Dumont\, Y. Canac\, O. Baslé\, M. Smietana\, Nat. Comm.\, 2026\, 17:7527 \n_ \nContact : anne.milet@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/elise-dumont-institut-de-chimie-de-nice-universite-cote-dazur/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261016T103000
DTEND;TZID=Europe/Paris:20261016T113000
DTSTAMP:20260918T091036Z
CREATED:20260918T091036Z
LAST-MODIFIED:20260918T091036Z
UID:10000261-1792146600-1792150200@sfp-alpes.fr
SUMMARY:Xavier RIBAS SALAMAÑA (Universitat de Girona)
DESCRIPTION:Supramolecular Nanocages as Masks for Fullerene Regiofunctionalization and Beyond\nRésumé : \nThe design of a confined cavity dictates the type of guest to be encapsulated\, and supramolecular cages are tunable scaffolds that allow the rational design of their cavities. Nowadays\, easily accessible C60 and C70 fullerene mono-adducts are mainly used in any application (1) due to the hampered accessibility to pure alternative fullerene poly-adduct derivatives. In general\, multi-adduct mixtures with uncontrolled regioselectivity (multi-isomers) are obtained\, and chromatographic purification is too costly and time-consuming. Herein\, porphyrin-based supramolecular nanocapsules (2\,3) are used as supramolecular shadow masks to tame the over-reactivity of Bingel-type cyclopropanation reactions and to have full control over the equatorial regioselectivity\nand the number of additions. Furthermore\, the regioselectivity control is finely tuned using a three-shell Matryoshka-like assembly towards synthesizing a single trans-3 bis-Bingel-C60 for the first time (4). Also\, the mask strategy is extended to C60 and C70 for Bingel and Diels-Alder (5\,6). We envision that the described protocol will produce a plethora of derivatives for applications such as solar cells. We will also discuss our recent selective purification of fullertube mixtures and beyond (7\,8). \nReferences :\n1. E. Castro\, L. Echegoyen et al. J. Mater. Chem. C\, 2018\, 6\, 2635.\n2. C. García-Simón\, X. Ribas\, et al. Nat. Commun. 2014\, 5:5557.\n3. C. Fuertes-Espinosa\, X. Ribas\, et al\, Chem 2020\, 6\, 169–186.\n4. E. Ubasart\, X. Ribas\, et al\, Nat. Chem. 2021\, 13\, 420-427.\n5. V. Iannace\, X. Ribas et al\, J. Am. Chem. Soc. 2024\, 146\, 5186−5194.\n6. T. Pèlachs\, X. Ribas et al\, CCS Chem. 2025\, 7\, 703–715\n7. V. Iannace\, X. Ribas et al\, J. Am. Chem. Soc. 2025\, 147\, 36079−36084\n8. V. Iannace\, X. Ribas\, Acc. Chem. Res. 2026\, 59\, 1414−1425 \n_ \nContact : noemie.lalaoui@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/xavier-ribas-salamana-universitat-de-girona/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261016T111500
DTEND;TZID=Europe/Paris:20261016T121500
DTSTAMP:20260918T092550Z
CREATED:20260918T092501Z
LAST-MODIFIED:20260918T092550Z
UID:10000262-1792149300-1792152900@sfp-alpes.fr
SUMMARY:Gyorgy SZALOKI (Université Paul Sabatier – Toulouse)
DESCRIPTION:Towards confined gold catalysis\nRésumé : \nGold complexes have been the subject of an intense research over the past decade.[1] The main driving force to this interest is to impart new reactivity to these complexes\, that can be leveraged in catalysis. In addition to the widely used ligand engineering strategy\,[2] the concept of confining gold complexes within supramolecular cages has also shown a great\npotential.[3] Toste et coll. have demonstrated\, that small cationic gold complexes (LAu+\, L = Me3P)\, generated within anionic cages show a markedly different reactivity compared to their non-confined analogues. However\, the small cavity size of the cage (251 Å3) has not allowed to extend this concept to larger complexes (L = tBuP\, NHC) and substrates. Indeed\, one obstacle\nto overcome is the synthesis of large anionic cages\, that is far from being straightforward.\nIn order to design and synthesize large anionic cages\, we have implemented a rational approach combining modellizations and cavity size calculations.[4] As a result\, we have prepared an anionic\, cyclotricatechylene based supramolecular cage 1 with a large cavity (558 Å3).[5] Recently\, we have been studying the host-guest chemistry of this cage\, in order to prepare the confined gold-catalyst (Au+@1\, Figure 1). The catalytic activity of Au+@1 is being studied\, with special attention to the synthetically challenging gold catalyzed macrocyclizations. \nFigure 1. Concept: Using the confinement effect to alter the reactivity of gold complexes. \nAcknowledgements\nThe CNRS\, the ANR and the French Ministry of Higher Education and Research is gratefully acknowledged for funding. \nReferences\n[1] L. Rochigiani\, M. Bochmann Chem. Rev. 2021\, 121\, 8364.\n[2] J. Rodriguez\, G. Szalóki\, E. D. Sosa Carizzo\, N. Saffon-Merceron\, K. Miqueu\, D. Bourissou Angew. Chem. Int. Ed.\, 2020\, 59\, 1511;\n(b) G. Szalóki\, J. Babinot\, V. Martin-Diaconescu\, S. Mallet-Ladeira\, Y. Garcia-Rodeja\, K. Miqueu\, D. Bourissou Chem. Sci. 2022\, 13\, 10499.\n[3] M. Morimoto\, S. M. Bierschenk\, K. T. Xia\, R. G. Bergman\, K. N. Raymond\, D. F. Toste Nat. Catal. 2020\, 3\, 969.\n[4] J. V. S. Guerra\, L. F. G. Alves\, D. Bourissou\, P. S. Lopes-de-Oliveira\, G. Szalóki J. Chem. Inf. Model. 2023\, 63\, 3772.\n[5] Y. Diack\, S. Mallet-Ladeira\, D. Lesage\, J. V. S. Guerra\, D. Bourissou\, G. Szalóki Chem. Commun. 2025\, 61\, 8003 \n_ \nContact : noemie.lalaoui@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/gyorgy-szaloki-universite-paul-sabatier-toulouse/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
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DTSTART;TZID=Europe/Paris:20261016T133000
DTEND;TZID=Europe/Paris:20261016T153000
DTSTAMP:20260911T131722Z
CREATED:20260911T131722Z
LAST-MODIFIED:20260911T131722Z
UID:10000252-1792157400-1792164600@sfp-alpes.fr
SUMMARY:Soutenance de Thèse par Irene SUAREZ ANTUNA (DCM (équipe CIRe))
DESCRIPTION:Bio-inspired strategies for small molecule activation: from photochemical H2 production to electrochemical CO2 reduction\n_ \nContact : Nathalie.Camerino@univ-grenoble-alpes.fr \n 
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-irene-suarez-antuna-dcm-equipe-cire/
LOCATION:Maison Jean Kuntzmann – amphithéâtre\, 110\, rue de la Chimie\, Saint-Martin-d'Hères\, 38400\, France
CATEGORIES:Soutenance,Soutenance de Thèse
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DTSTART;TZID=Europe/Paris:20261026T140000
DTEND;TZID=Europe/Paris:20261026T150000
DTSTAMP:20260911T134555Z
CREATED:20260911T134555Z
LAST-MODIFIED:20260911T134555Z
UID:10000253-1793023200-1793026800@sfp-alpes.fr
SUMMARY:Ramón RIAL (Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS)\, Departamento de Física Aplicada\, Universidade de Santiago de Compostela\, Spain)
DESCRIPTION:Dynamic Supramolecular Eutectogels with Reversible Light Driven Reconfiguration\nRésumé : \nDeep eutectic solvents (DESs) constitute a highly tunable class of liquid media formed by the association of two or more components (e.g.\, a hydrogen-bond donor and an organic salt)\, whose extensive hydrogen bonding interactions result in a pronounced depression of the melting point. Their composition-dependent physicochemical properties make DESs particularly attractive for directing the self-assembly of functional soft materials [1\,2]. In this context\, eutectogels (gels formed within DES media)\, offer a versatile platform in which solvent–solute interactions can be exploited to modulate macroscopic material properties beyond those dictated by the gelator alone [3]. \nHerein\, we report a versatile strategy for the design of light-responsive eutectogels with intrinsically tunable mechanical properties. The approach relies on the supramolecular co-assembly of an amphiphilic component with a rationally designed azobenzene derivative engineered for high solubility in water-free DES media. Through complementary characterization across molecular and mesoscale length scales\, we provided a detailed understanding of the heterotypic interactions underlying the formation of elongated\, one-dimensional supramolecular networks. We further establish that photoisomerization of the azobenzene units induces pronounced rearrangements of these networks\, providing a molecular-level mechanism for controlling the material’s hierarchical organization. \nUpon ultraviolet irradiation\, this molecular reconfiguration leads to an abrupt gel-to-sol transition\, effectively erasing the material’s solid-like mechanical response. Subsequent exposure to visible light reverses the process\, restoring the gel state and recovering a mechanically robust network that remains stable during prolonged storage without appreciable loss of performance. Remarkably\, the optically driven transition is highly reversible and cyclable\, enabling repeated switching between gel and sol states without detectable deterioration of structural integrity or mechanical properties. Collectively\, these results demonstrate how molecular photochemical events can be translated into reversible macroscopic mechanical actuation\, establishing DES-based supramolecular eutectogels as promising platforms for dynamically reconfigurable soft matter. \nReferences :\n[1] Hansen\, B. et al.\, Chem. Rev. 2021\, 101\, 1232-1285.\n[2] P. A. Mercadal\, A. González\, A. Beloqui\, L. C. Tomé\, D. Mecerreyes\, M. Calderón and M. L. Picchio\, JACS Au\, 2024\, 4\, 3744-3758.\n[3] A. Sanchez-Fernandez\, J. F. Poon\, A. E. Leung\, S. F. Prevost and C. Dicko\, ACS Nano\, 2024\, 18\, 18314-18326. \nOrsolya Czakkel (College 9 Secretary) \nExternal visitors may ask for a site access to : tellier@ill.fr \nZoom link : https://ill.zoom.us/j/93326326401?pwd=mq7JqMLctpkqw7hIcPWTq6QGt8nGOg.1 – Password : SeminarC3 \n 
URL:https://sfp-alpes.fr/event/ramon-rial-centro-singular-de-investigacion-en-quimica-bioloxica-e-materiais-moleculares-ciqus-departamento-de-fisica-aplicada-universidade-de-santiago-de-compostela-spain/
LOCATION:ILL – Salle de Séminaire (110-111)\, ILL 50 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
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