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DTSTART;TZID=Europe/Paris:20260710T110000
DTEND;TZID=Europe/Paris:20260710T120000
DTSTAMP:20260703T084646Z
CREATED:20260626T134823Z
LAST-MODIFIED:20260703T084646Z
UID:10000211-1783681200-1783684800@sfp-alpes.fr
SUMMARY:Marion JESPERSEN (Department of Microbiology\, Monash University)
DESCRIPTION:Functional and structural insights into O2-adapted hydrogenases\nRésumé : \nHydrogenases are metalloenzymes that catalyse the interconversion of protons and electrons into molecular hydrogen (H2)\, providing valuable models for robust and sustainable H2 catalysts. However\, most characterised hydrogenases are inhibited by oxygen (O2)\, limiting their biotechnological potential. Although diverse [NiFe]- and [FeFe]-hydrogenases have evolved adaptations that support activity\, stability\, or recovery following O2 exposure\, the molecular basis of O2 adaptation remains poorly understood. \nIn this talk\, I will present our ongoing work on O2-adapted hydrogenases from bacteria and archaea inhabiting aerobic soils\, thermoacidophilic environments\, and the gut. By combining physiological\, biochemical\, structural\, and computational approaches\, we investigate how distinct hydrogenase lineages support H2 metabolism under oxygen-exposed conditions.These systems include the high-affinity group 1h [NiFe]-hydrogenase from Mycobacterium smegmatis\, the Sulfolobales clade 2 [NiFe]-hydrogenase from Metallosphaera sedula\, and gut microbial [FeFe]-hydrogenases\, including group B enzymes from Bacteroides species and a group A1 enzyme from Clostridium perfringens. Together\, they highlight the diversity of hydrogenase architectures\, cofactor arrangements\, and electron-transfer strategies that may contribute to O2 resilience. \nOverall\, this work expands the functional and structural repertoire of O2-adapted hydrogenases\, informing our understanding of microbial H2 metabolism and the search for enzymes suited to H2-based biocatalysis. \n_ \nCes séminaires\, ainsi que les soutenances et cours sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire et de l’adresser\, plus de 48h à l’avance\, à ce contact. Pensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/marion-jespersen-department-of-microbiology-monash-university/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260720T110000
DTEND;TZID=Europe/Paris:20260720T120000
DTSTAMP:20260703T133346Z
CREATED:20260703T133346Z
LAST-MODIFIED:20260703T133346Z
UID:10000216-1784545200-1784548800@sfp-alpes.fr
SUMMARY:Garry S. HANAN (Département de chimie\, Université de Montréal\, Canada)
DESCRIPTION:Developing New Photosensitizers based on Transition Metal Ions for Green Energy Applications\nRésumé : \nRising global population and increased CO2 levels in the atmosphere have focused attention on developing alternative and widely available carbon-free energy sources (1\,2). Ourresear ch focuses on harnessing the unique properties of excited states in metal complexes to drive self-assembly processes and develop innovative energy applications. By leveraging the photophysical and photochemical behaviors of these complexes\, we explore how light-induced excitations can be utilized to control molecular organization and energy transfer at the nanoscale. The parallels with Natural Photosynthesis are evident: light energy is captured by self-assembled Light Harvesting Complexes and is channeled to a reaction centre which induces electron transfer and the eventual production of chemical energy (3). \nOur approach involves the synthesis of polypyridyl-based metal complexes\, which are known for their stability and tunable electronic properties. By manipulating the excited states of these complexes\, we demonstrate how light can act as a stimulus to induce self-assembly\, leading to the formation of well-defined nanostructures with potential applications in catalysis\, sensing\, and optoelectronics (4). Additionally\, we extend our approach to the development of photoactive molecular devices capable of storing and transferring electrons\, offering insights into the design of next-generation photosensitizers for chemical energy production (5). We have also moved from second- and third-row transition metal ions to the first row\, and explore energy applications of these abundant\, inexpensive and relatively non-toxic metal ions (6). \nReferences\n1. https://ourworldindata.org/world-population-growth (01-05-2026).\n2. https://www.iea.org/world (01-05-2026).\n3. V. Balzani\, A. Credi\, M. Venturi\, Chem Sus Chem 2008\, 1\, 26.\n4. B. Laramée-Milette\, F. Puntoriero\, F. Nastasi\, S. Campagna\, G. S. Hanan\, Chem. Eur. J.\, 2017 23\, 16497.\n5. G. M. Mercier\, E. Rousset\, I. Oubaha\, K. Bandyopadhyay\, A. K. Pal\, I. Ciofini\, L.-M. Chamoreau\, V. Marvaud\, G. S. Hanan\, Chem. Commun. 2025 61 (77)\, 14911-14914.\n6. A. Saha\, G. Turner\, M. Cibian\, S. Serroni\, S. Genovese\, S. Campagna\, G. S. Hanan\, F. Nastasi\, submitted for publication. \nGarry Hanan is professor in the Department of Chemistry at the Université de Montréal\, where he leads the Green Energy Group and is a member of the Centre for Green Chemistry and Catalysis. He earned his B. Sc. from the University of Winnipeg\, Canada\, his PhD from Université Louis Pasteur in Strasbourg\, France\, under the supervision of Jean-Marie Lehn and subsequently conducted postdoctoral studies in Germany with Manfred T. Reetz and in Italy with Vincenzo Balzani and Sebastiano Campagna. Professor Hanan’s research focuses on the design and synthesis of supramolecular photocatalysts capable of harvesting solar energy to drive chemical\ntransformations\, most notably the photoproduction of fuels via water-splitting (producing H₂) and CO₂ reduction.\nHe has received numerous distinctions\, including awards from IUPAC and NSERC\, highlighting his contributions to sustainable chemistry and molecular materials science. He also actively promotes international student exchange. \nContact : frederique.loiseau@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/garry-s-hanan-departement-de-chimie-universite-de-montreal-canada/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
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DTSTART;TZID=Europe/Paris:20260721T140000
DTEND;TZID=Europe/Paris:20260721T150000
DTSTAMP:20260709T121303Z
CREATED:20260709T121303Z
LAST-MODIFIED:20260709T121303Z
UID:10000218-1784642400-1784646000@sfp-alpes.fr
SUMMARY:Ben HUMPHREYS (Institut Laue-Langevin (ILL) Grenoble\, France)
DESCRIPTION:Advancing our Understanding of Responsive Polymer Brushes\nRésumé : \n\nInterfacial properties of a surface can be extensively modified through the addition of a polymer brush layer; a dense array of end-tethered polymers grafted to a surface. When a polymer brush is synthesised with a stimulus responsive polymer\, the surface properties can be tailored to respond\, often reversibly\, to external stimuli such as temperature\, light\, pH\, solvent or electric fields. While these so-called smart materials are particularly promising for high-value applications such as sensors\, nanoactuation and microfluidics\, their response can be significantly influenced by additives such as osmolytes and salts. Unlike untethered polymer systems\, research into the influence of additives for responsive polymer brushes has been sparse\, yet this knowledge is crucial when advancing their utilisation in biomedical and industrial applications. \nThroughout my research career I have primarily focused on the influence of salts and osmolytes on temperature and pH responsive homo- and co-polymer brushes. I will firstly discuss my synthetic methodologies and choice of responsive polymers. This will be followed by a comprehensive outline of the approaches used to investigate these responsive coatings. Here\, starting with the simplest systems\, then gradually increasing complexity\, I have been able to systematically understand the influence of individual additives/changes. This information is invaluable when considering the complex real-world applications that can benefit from the utilisation of smart\, responsive polymer brush surface coatings. \nShort Bio/CV\nIn 2015 I graduated from the University of Newcastle\, Australia\, with a Bachelor of Science\, 1st class honors\, majoring in Chemistry\, followed by my PhD at the same university (2015-2019) titled “Nanostructure of Temperature Responsive Polymer Brushes Modulated by Salt Identity”. I then accepted a post-doc position at Lund University in Sweden\, investigating the internal structural changes of a triglyceride film throughout enzymatic digestion\, with particular focus on the influence of pH and how this influences the species present throughout the lipolytic process. In 2023 I started in my current position as instrument responsible for the D17 neutron reflectometer at the ILL where I have re-established my research on responsive polymer brushes with a focus on osmolyte and salt additives in aqueous solutions. \n_ \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/ben-humphreys-institut-laue-langevin-ill-grenoble-france/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
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DTSTART;TZID=Europe/Paris:20260918T140000
DTEND;TZID=Europe/Paris:20260918T160000
DTSTAMP:20260703T085657Z
CREATED:20260703T085657Z
LAST-MODIFIED:20260703T085657Z
UID:10000215-1789740000-1789747200@sfp-alpes.fr
SUMMARY:Soutenance de thèse par Mélanie LOPES (CEA-Irig/BGE)
DESCRIPTION:Vascularisation d’ilots pancréatiques sur puce microfluidique pour le suivi du diabète de type 1\nRésumé : \nLe diabète de type 1 est une maladie auto-immune caractérisée par la destruction des cellules βpancréatiques. Bien que la transplantation d’îlots de Langerhans puisse restaurer une sécrétion endogène d’insuline chez certains patients\, son efficacité à long terme reste limitée par la perte du greffon\, une revascularisation insuffisante\, l’hypoxie\, l’inflammation et le rejet immunitaire. Un enjeu majeur est donc de développer des modèles humains in vitro capables de reproduire le microenvironnement des îlots pancréatiques\, notamment leur niche vasculaire. \nL’objectif de cette thèse était de développer des modèles humains vascularisés et perfusables d’îlots pancréatiques compatibles sur la puce microfluidique serpentin précédemment développée. Premièrement\, des organoïdes pancréatiques multicellulaires pré-endothélialisés\, appelés Langerhanoïdes\, ont été générés à partir de cellules EndoCβH5 ou d’îlots humains dissociés\, associés à des cellules endothéliales et stromales. Leur structure 3D\, la sécrétion d’insuline\, le développement d’un réseau endothélial endothéliales avec le microenvironnement et la perfusion sur la puce microfluidique serpentin ont été évalués. Concernant les Langerhanoïdes\, les résultats ont montré que l’identité et la proportion des cellules stromales influençait fortement la compaction des Langerhanoïdes et l’intégration des cellules endothéliales. \nDans un deuxième temps\, un gel à base de lysat plaquettaire humain (hPLG) a été développé afin de fournir un microenvironnement bioactif\, sans composant xénogénique\, capable de soutenir le développement d’un réseau endothélial et la survie des cellules endocrine. Cependant\, les propriétés mécaniques d’hPLG a limité son utilisation sur puce. Ainsi\, un gel hybride associant lysat plaquettaire humain et fibrine humaine a donc été développé afin d’améliorer les propriétés mécaniques du gel en conservant ses propriétés pro-angiogéniques et cytoprotectrices. \nCe travail met en évidence le potentiel\, mais aussi les défis\, associés au développement de modèles pancréatiques perfusables. La formation d’un réseau endothélial a été obtenu\, mais la perfusion intratissulaire reste dépendante de la composition cellulaire\, des propriétés mécaniques des gels et du design de la puce. Ces modèles sont prometteurs pour étudier les interactions endocrines–vasculaires\, le recrutement immunitaire\, les réponses aux traitements\, la transplantation d’îlots et la médecine personnalisée dans le diabète de type 1​. ​​​​ \n  \n\n\nATTENTION ! L’entrée du site CEA-Grenoble nécessite une autorisation préalable et sur présentation de votre pièce d’identité le jour de votre venue (CI ou passeport\, car le permis de conduire n’est pas recevable). Veuillez impérat​ivement nous contacter par mail avant le 04 septembre : envoyer un mail
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-melanie-lopes-cea-irig-bge/
LOCATION:CEA – Salle de Séminaire IRIG (1005 – 445)\, Laboratoire Irig/Spintec\, salle de séminaire 445\, bâtiment 1005\, CEA-Grenoble\, Grenoble
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:odile.rossignol@cea.fr
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