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DTSTART;TZID=Europe/Paris:20260929T140000
DTEND;TZID=Europe/Paris:20260929T150000
DTSTAMP:20260910T152942Z
CREATED:20260910T152942Z
LAST-MODIFIED:20260910T152942Z
UID:10000248-1790690400-1790694000@sfp-alpes.fr
SUMMARY:Natali PLANK (School of Chemical and Physical Sciences and the MacDiarmid Institute for Advanced Materials and Nanotechnology\, Victoria University of Wellington\, New Zealand)
DESCRIPTION:Nanowire and carbon nanotube device structures for Biosensors and Artificial Neural Networks\nRésumé : \nCarbon nanotube (CNT) networks offer a particularly attractive platform due to their simple fabrication\, tunable electronic properties\, and ability to be interrogated through multiple electrical contacts on a single chip [1]. Functionalised carbon nanotube and graphene field effect transistors (CNTFETs and GFETs) have been used as the active channel in biosensors\, with the future promise of lab-on-a-chip diagnostics strongly motivating the research [2]. The ability to effectively sense analytes depends on multiple factors\, the conductivity of the platform [3]\, the robustness of the functionalisation and the selectivity and function of the receptor [4]. \nCarbon nanotubes also offer an interesting base platform for neuromorphic computing via physical reservoirs. Physical reservoir computing exploits the intrinsic dynamics of complex materials to perform temporal information processing with low power consumption and minimal training requirements. Disordered networks of memristive nanowires have emerged as promising neuromorphic architectures\, as they can host large numbers of nonlinear junctions that collectively generate rich spatiotemporal dynamics [5-7]. \nHere I will present our recent work on the development of the CNTFET and GFET platforms with aptamers and insect odorant receptors and the different challenges and device constraints we have encountered. I will also present our work on the development of the CNT platform for physical reservoir computing applications. \n[1]      Topinka\, M. A\, et al. Nano Lett. 2009 9\, 1866–1871 \n[2]      T An et al\, Lab Chip\, 2010\,10\,2052-2056 \n[3]      M Thanihaichelvan M\, et al\, Biosensors and Bioelectronics\, 2019\, 130\, 408-413 \n[4]      Nguyen et al.\, Nanomaterials\, 2021 11 (9)\, 2280 \n[5]      Milano\, G\, et al. Nat. Mater. 2022\, 21 (2)\, 195–202. \n[6]      Kotooka\, T.\, et al. Thermally Stable Ag 2 Se Nanowire Network as an Effective In-Materio Physical Reservoir Computing Device. 2024\, 2400443\, 1–10.  \n[7]      Zhu\, R.\, et al Online Dynamical Learning and Sequence Memory with Neuromorphic Nanowire Networks. Nat. Commun. 2023\, 14 (1)\, 6697.  \n\nShort Bio/CV\nDr Natalie Plank is Deputy Director for Commercialisation and Industry Engagement and an Associate Professor in Physics in the School of Chemical and Physical Sciences at Victoria University of Wellington. Natalie completed a BSc (Hons) in Astrophysics at The University of Edinburgh before doing an MSc in Microelectronics. She then completed her PhD on the functionalisation of carbon nanotubes for molecular electronics with Rebecca Cheung also at The University of Edinburgh. \nNatalie’s research interests are in the area of nanomaterial device fabrication and the characterisation of novel materials. Her current work focuses on nanomaterial device platforms for sensing technology and artificial neural networks. She is interested in carbon nanotubes and ZnO nanowires for nanowire transistor applications and in particular the ability to functionalise the nanomaterial channels with specific biomarkers or memristive molecules. Natalie’s core interests are in low cost fabrication techniques which allow for high throughput of devices whilst maintaining the particular material properties of the unique nanowire system. \n_ \nContact : deborah.verger@grenoble-inp.fr
URL:https://sfp-alpes.fr/event/natali-plank-school-of-chemical-and-physical-sciences-and-the-macdiarmid-institute-for-advanced-materials-and-nanotechnology-victoria-university-of-wellington-new-zealand/
LOCATION:LMGP – salle des séminaires\, Grenoble INP -Phelma 3 parvis Louis Néel\, Grenoble\, 38054\, France
CATEGORIES:Séminaire
ORGANIZER;CN="LMGP":MAILTO:deborah.verger@grenoble-inp.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260929T140000
DTEND;TZID=Europe/Paris:20260929T160000
DTSTAMP:20260827T161753Z
CREATED:20260827T161753Z
LAST-MODIFIED:20260827T161753Z
UID:10000231-1790690400-1790697600@sfp-alpes.fr
SUMMARY:Soutenance de Thèse par Léa VALET (CEA-Irig/Biosanté)
DESCRIPTION:Rôles respectifs de Bone Morphogenetic Protein 10 (BMP10) cardiaque et hépatique dans le système cardiovasculaire\nRésumé : \nL’Activin receptor-like kinase 1 (ALK1) est un récepteur principalement exprimé par les cellules endothéliales\, et les mutations perte de fonction de son gène\, ACVRL1\, sont responsables de la télangiectasie hémorragique héréditaire (HHT) aussi appelée maladie de Rendu-Osler\, une pathologie rare caractérisée par de multiples anomalies vasculaires. Ses ligands de haute affinité\, Bone Morphogenetic Protein 9 (BMP9) et Bone Morphogenetic Protein 10 (BMP10)\, jouent un rôle central dans le maintien de l’homéostasie vasculaire. BMP9 est produit par les cellules étoilées du foie\, tandis que BMP10 est classiquement décrit comme étant majoritairement synthétisé par les cardiomyocytes de l’oreillette droite. Toutefois\, des travaux récents ont mis en évidence une production de BMP10 par les cellules étoilées du foie\, remettant en question cette vision classique et suggérant l’existence d’une source hépatique jusqu’alors largement sous-estimée. Cette observation soulève une question fondamentale : quelle est l’origine du BMP10 circulant biologiquement actif et quelle est la contribution respective du cœur et du foie au maintien de l’homéostasie vasculaire dépendante d’ALK1 ? \nPour répondre à cette question\, nous avons développé de nouveaux modèles murins permettant une délétion tissu-spécifique de Bmp10 : une délétion inductible dans les cardiomyocytes et une délétion constitutive dans les cellules étoilées du foie. Ces modèles ont été croisés avec des souris invalidées pour Bmp9 afin d’analyser les conséquences vasculaires de la perte combinée des différents ligands capables d’activer ALK1. Après validation génétique de ces modèles\, nous avons cherché à identifier l’origine du BMP10 circulant biologiquement actif et à caractériser les conséquences physiopathologiques associées à la perte de ces deux ligands. \nDe manière surprenante\, nos résultats révèlent que la délétion de Bmp10 dans le foie entraîne une disparition complète du BMP10 circulant biologiquement actif\, tandis que sa délétion cardiaque n’altère ni sa concentration plasmatique ni son activité biologique. Ces données démontrent ainsi que\, contrairement à ce qui était admis jusqu’à présent\, le foie\, et non le cœur\, constitue la principale source de BMP10 circulant actif. Sur le plan phénotypique\, les souris déficientes pour Bmp9 et Bmp10 hépatique présentent d’importantes altérations vasculaires locales : perte de l’identité endothéliale des sinusoïdes hépatiques associée à une dérégulation de voies métaboliques et à une accumulation de fibres de collagène dans le foie. De façon remarquable\, ces altérations ne se limitent pas au foie mais s’accompagnent d’une atteinte vasculaire systémique\, caractérisée par l’apparition d’anomalies artérioveineuses au niveau intestinal et rénal. Nous mettons également en évidence une atteinte pulmonaire sévère associée à une dilatation marquée des capillaires pulmonaires\, une désorganisation profonde du parenchyme pulmonaire ainsi qu’une augmentation importante de la perméabilité vasculaire. À l’inverse\, aucun de ces phénotypes n’est observé lors de la délétion combinée de Bmp9 et de Bmp10 cardiaque. \nCe travail révèle ainsi un rôle jusqu’alors insoupçonné du foie comme source principale de BMP10 circulant actif. En association avec BMP9\, ce ligand apparaît indispensable au maintien de l’intégrité endothéliale et de l’homéostasie vasculaire. Ces résultats redéfinissent notre compréhension des mécanismes contrôlant l’activation endothéliale d’ALK1 in vivo et apportent un nouvel éclairage sur les mécanismes impliqués dans les pathologies vasculaires associées à cette voie de signalisation\, notamment la maladie de Rendu-Osler. ​ ​​​​ \n\n\n_ \nTitle : The Respective Roles of Cardiac and Hepatic Bone Morphogenetic Protein 10 (BMP10) in the Cardiovascular System \nAbstract​​ : \nActivin receptor-like kinase 1 (ALK1) is a receptor predominantly expressed by endothelial cells\, and loss-of-function mutations in its encoding gene\, ACVRL1\, are responsible for hereditary hemorrhagic telangiectasia (HHT)\, also known as Rendu-Osler disease\, a rare vascular disorder characterized by multiple vascular abnormalities. Its high-affinity ligands\, Bone Morphogenetic Protein 9 (BMP9) and Bone Morphogenetic Protein 10 (BMP10)\, play a central role in maintaining vascular homeostasis. BMP9 is produced by hepatic stellate cells\, whereas BMP10 is essentially described as synthesized by right atrial cardiomyocytes. However\, recent studies have demonstrated BMP10 production by hepatic stellate cells\, challenging this classical view and suggesting the existence of a previously underevaluated hepatic source. This observation raises a fundamental question: what is the origin of biologically active circulating BMP10\, and what are the respective contributions of the heart and the liver to ALK1-dependent vascular homeostasis? \nTo address this question\, we developed novel mouse models allowing tissue-specific deletion of Bmp10\, including an inducible cardiomyocyte-specific knockout and a constitutive hepatic stellate cell-specific knockout (KO). These models were crossed with Bmp9-KO mice to investigate the vascular consequences of the combined loss of the different ligands capable of activating ALK1. Following genetic validation of these models\, we sought to identify the origin of biologically active circulating BMP10 and to characterize the pathophysiological consequences associated with the loss of these two ligands. \nStrikingly\, our results demonstrate that hepatic deletion of Bmp10 leads to the complete loss of biologically active circulating BMP10\, whereas cardiac deletion does not affect either its plasma concentration or its biological activity. These findings demonstrate that\, contrary to the current view\, the liver\, rather than the heart\, is the primary source of biologically active circulating BMP10. Phenotypically\, mice deficient in Bmp9 and hepatic Bmp10 display major local vascular alterations associated with disruption of liver sinusoidal endothelial identity\, dysregulation of hepatic metabolic pathways\, and collagen deposition in the liver. Remarkably\, these alterations are not restricted to the liver but are accompanied by systemic vascular defects\, including the development of arteriovenous abnormalities in the intestine and kidneys. We also demonstrate severe pulmonary alterations characterized by marked dilation of pulmonary capillaries\, profound disruption of lung parenchymal architecture\, and a substantial increase in vascular permeability. In contrast\, none of these phenotypes are observed following the combined deletion of Bmp9 and cardiac Bmp10. \nOverall\, this work uncovers a previously unrecognized role of the liver as the principal source of biologically active circulating BMP10. Together with BMP9\, this ligand is essential for maintaining endothelial integrity and vascular homeostasis. These findings redefine our understanding of the mechanisms governing endothelial ALK1 activation in vivo and provide new insights into the mechanisms underlying vascular diseases associated with this signaling pathway\, particularly hereditary hemorrhagic telangiectasia. \n_ \nATTENTION ! L’entrée d​u site CEA-Grenoble nécessite une autorisation préalable et sur présentation de votre pièce d’identité le jour de votre venue (CI ou passeport\, car le permis de conduire n’est pas recevable). Veuillez impérat​ivement nous contacter par mail avant le 19​ septembre : envoyer un mail \n\n\n\n\nNote : Entry to the CEA-Grenoble site requires prior authorization and the presentation of your ID on the day of your visit (ID card or passport; driver’s licenses are not accepted). Please request this authorization before September 19th to send an e-mail​
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-lea-valet-cea-irig-biosante/
LOCATION:CEA – Salle de Séminaire IRIG (1005 – 445)\, 17\, avenue des Martyrs\, Grenoble\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IRIG - CEA":MAILTO:irig.communication@cea.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261001T130000
DTEND;TZID=Europe/Paris:20261001T140000
DTSTAMP:20260917T134744Z
CREATED:20260917T134744Z
LAST-MODIFIED:20260917T134744Z
UID:10000255-1790859600-1790863200@sfp-alpes.fr
SUMMARY:Alice CLEYNEN (LJK\, Grenoble)
DESCRIPTION:Les différentes facettes de l’ARN : les opportunités ouvertes par le séquençage direct par nanopore\nRésumé : \nLe séquençage direct de l’ARN (Direct RNA Sequencing\, DRS) par nanopore (Oxford Nanopore Technologies) est une technologie qui lit les molécules d’ARN telles qu’elles existent dans la cellule\, sans jamais les copier. Cette absence d’amplification change la donne à plusieurs titres : elle évite les biais d’estimation de l’abondance des ARN inhérents à toute étape de PCR\, et surtout elle préserve les modifications chimiques qui décorent nativement les molécules — des marques aujourd’hui reconnues comme un véritable langage réactionnel. Autre atout\, les lectures produites (des « long-reads ») couvrent la molécule dans son intégralité\, ce qui permet d’assigner directement chaque lecture à un isoforme\, plutôt que de devoir les reconstruire a posteriori à partir de données au niveau du gène. Cerise sur le gâteau\, le DRS donne aussi accès à la longueur de la queue poly(A)\, dont un nombre croissant d’études souligne le rôle déterminant dans la stabilité et la traduction des ARN. \n_ \nContact : lucie.lamothe@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/alice-cleynen-ljk-grenoble/
LOCATION:IMAG – Salle de Réunion\, 150 place du Torrent\, St Martin d’Hères\, 38400\, France
CATEGORIES:Séminaire
ORGANIZER;CN="TIMC - IMAG":MAILTO:lucie.lamothe@univ-grenoble-alpes.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261001T140000
DTEND;TZID=Europe/Paris:20261001T150000
DTSTAMP:20260911T092949Z
CREATED:20260911T092949Z
LAST-MODIFIED:20260911T092949Z
UID:10000250-1790863200-1790866800@sfp-alpes.fr
SUMMARY:Zacharias AMARA (Conservatoire National des Arts et Métiers\, Paris)
DESCRIPTION:From Interface Engineering to Wavelength Control: Selective Photocatalytic Oxidations\nRésumé : \nIn this research seminar\, we present our group’s recent advances in the development of heterogenized photocatalytic systems for selective oxidation reactions. Central to our approach is the creation of well-defined catalytic interfaces through simple and scalable heterogenization strategies\, enabling the use of green solvents while simultaneously enhancing catalyst reactivity\, robustness\, and long-term stability. These engineered interfaces provide a versatile platform for efficient photo-oxidation under mild and sustainable reaction conditions. \nBeyond catalyst design\, control over interfacial phenomena is extended to the reactor level through the implementation of continuous-flow processing. Flow photoreactors offer precise control over mass and heat transfer\, as well as improved photon management\, allowing these heterogenized systems to operate at significantly higher space–time yields. As a result\, photo-\noxidation reactions can be performed with unprecedented productivity\, reproducibility\, and scalability. \nFinally\, an additional level of control is achieved by tuning the excitation wavelength across the visible spectrum and toward lower-energy photons in the near-infrared (NIR) region. Access to wavelength-selective photoactivation enables new photo-oxygenation pathways and unlocks levels of chemoselectivity that are inaccessible under conventional higher-energy irradiation. Together\, the combined control of catalytic interfaces\, reactor architecture\, and light energy establishes a unified strategy for highly selective and efficient photocatalytic oxidation processes. \nFor key references from our group\, see: a) Amara\, Zimberlin\, Atakpa\, Al Ayi\, Lancel\, ACS Inorg. Org. Chem. Au\, 2026\, 6\, 8–22 ; b) Al Ayi\, Atakpa\, Arab\, Lancel\, Amara\, Eur. J. Org. Chem.\, 2024 e202400634 ; c) Lancel\, Lindgren\, Monnereau\, Amara\, Photochem. Photobiol. Sci. 2023\, 23\, 79-92 ; d) Lancel\, Golisano\, Monnereau\, Gomez\, Port\, Amara\, ACS Sustain. Chem. Eng. 2023\, 11\, 15674–15684 ; e) Lancel\, Zimberlin\, Gomez\, Port\, Khrouz\, Monnereau\, Amara J. Org. Chem. 2023\, 88\, 10\, 6498–6508; f) Terra\, Desgranges\, Amara\, Moores\, Catalysis Today\, 2023\, 407\, 52-58 ; g) Lancel\, Gomez\, Port\, Amara\, Front. Chem. Eng.\, 2021\, 3\, 752364. ; h) Gellé\, Price\, Voisard\, Brodusch\, Gauvin\, Amara\, Moores\, ACS Appl. Mater. Interfaces\, 2021\, 13\, 35606-35616 ; i) Blanchard\, Asbai\, Cottet\, Boissonnat\, Port\, Amara\, Org. Process Res. Dev.\, 2020\, 24\, 822-826 ; j) Tambosco\, Segura\, Seyrig\, Cabrera\, Port\, Ferroud\, Amara\, ACS Catal. 2018\, 8\, 4383-4389 \n_ \nContact : adrien.quintard@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/zacharias-amara-conservatoire-national-des-arts-et-metiers-paris/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261015T140000
DTEND;TZID=Europe/Paris:20261015T150000
DTSTAMP:20260911T130347Z
CREATED:20260911T130150Z
LAST-MODIFIED:20260911T130347Z
UID:10000251-1792072800-1792076400@sfp-alpes.fr
SUMMARY:Elise DUMONT (Institut de Chimie de Nice\, Université Côte d’Azur)
DESCRIPTION:Modeling the dynamics of DNA (photo)lesions: from reactivity to repair\nRésumé : \nFormation and repair of DNA lesions embrace a rich and combinatorial chemistry\, where atomic-scale simulations are increasingly helpful to complement and extent experimental evidences. \nThe modeling of DNA structure\, dynamics\, and (photo)chemistry has benefited from a series of recent methodological developments that now allow\, for instance capturing DNA-photosensitizers interactions\, probing new excited-state mechanisms for DNA lesions induction or photostability [1]\, and rationalize the photochemistry or photocatalytic properties of drugs within DNA owing to hybrid QM/MM-MD schemes. \nI will present a series of examples where computational approaches can palliate\, at least partly\, the absence of NMR\, FRET or X-ray data for damaged DNA oligonucleotides\, DNA-drug\nbinding modes or even DNA-proteins interactions at the nucleosomal scale [2\,3]. I will also situate DNA-ligand interactions\, which can be helpful for the design of next-generation G-\nquadruplex-specific photosensitizers [4] or new DNA-inspired photocatalysts [5]. \n[1] A. Frances-Monerris\, H. Gattuso\, D. Roca-Sanjuan\, I. Tunon\, M. Marazzi\, E. Dumont\, A. Monari\, Chem. Sci.\, 2018\, 9:7902-7911\n[2] E. Matouskova\, E. Bignon\, V. E. P. Claerbout\, T. Drsata\, N. Gillet\, A. Monari. E. Dumont\, F. Lankas\, J. Chem. Theory. Comput.\, 2020\, 16(9):5972-5981\n[3] T. Wen\, M. Kermarrec\, E. Dumont\, N. Gillet\, M. M. Greenberg\, J. Am. Chem. Soc.\, 2023\, 145(43):23702-23714\n[4] M. Deiana et al.\, Nucl. Acids. Res.\, 2023\, 51(12):6264-6285\n[5] Z. Pastorel\, J. Zani\, M. Noël\, A. Bartocci\, S. Arseniyadis\, E. Dumont\, Y. Canac\, O. Baslé\, M. Smietana\, Nat. Comm.\, 2026\, 17:7527 \n_ \nContact : anne.milet@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/elise-dumont-institut-de-chimie-de-nice-universite-cote-dazur/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261016T103000
DTEND;TZID=Europe/Paris:20261016T113000
DTSTAMP:20260918T091036Z
CREATED:20260918T091036Z
LAST-MODIFIED:20260918T091036Z
UID:10000261-1792146600-1792150200@sfp-alpes.fr
SUMMARY:Xavier RIBAS SALAMAÑA (Universitat de Girona)
DESCRIPTION:Supramolecular Nanocages as Masks for Fullerene Regiofunctionalization and Beyond\nRésumé : \nThe design of a confined cavity dictates the type of guest to be encapsulated\, and supramolecular cages are tunable scaffolds that allow the rational design of their cavities. Nowadays\, easily accessible C60 and C70 fullerene mono-adducts are mainly used in any application (1) due to the hampered accessibility to pure alternative fullerene poly-adduct derivatives. In general\, multi-adduct mixtures with uncontrolled regioselectivity (multi-isomers) are obtained\, and chromatographic purification is too costly and time-consuming. Herein\, porphyrin-based supramolecular nanocapsules (2\,3) are used as supramolecular shadow masks to tame the over-reactivity of Bingel-type cyclopropanation reactions and to have full control over the equatorial regioselectivity\nand the number of additions. Furthermore\, the regioselectivity control is finely tuned using a three-shell Matryoshka-like assembly towards synthesizing a single trans-3 bis-Bingel-C60 for the first time (4). Also\, the mask strategy is extended to C60 and C70 for Bingel and Diels-Alder (5\,6). We envision that the described protocol will produce a plethora of derivatives for applications such as solar cells. We will also discuss our recent selective purification of fullertube mixtures and beyond (7\,8). \nReferences :\n1. E. Castro\, L. Echegoyen et al. J. Mater. Chem. C\, 2018\, 6\, 2635.\n2. C. García-Simón\, X. Ribas\, et al. Nat. Commun. 2014\, 5:5557.\n3. C. Fuertes-Espinosa\, X. Ribas\, et al\, Chem 2020\, 6\, 169–186.\n4. E. Ubasart\, X. Ribas\, et al\, Nat. Chem. 2021\, 13\, 420-427.\n5. V. Iannace\, X. Ribas et al\, J. Am. Chem. Soc. 2024\, 146\, 5186−5194.\n6. T. Pèlachs\, X. Ribas et al\, CCS Chem. 2025\, 7\, 703–715\n7. V. Iannace\, X. Ribas et al\, J. Am. Chem. Soc. 2025\, 147\, 36079−36084\n8. V. Iannace\, X. Ribas\, Acc. Chem. Res. 2026\, 59\, 1414−1425 \n_ \nContact : noemie.lalaoui@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/xavier-ribas-salamana-universitat-de-girona/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261016T111500
DTEND;TZID=Europe/Paris:20261016T121500
DTSTAMP:20260918T092550Z
CREATED:20260918T092501Z
LAST-MODIFIED:20260918T092550Z
UID:10000262-1792149300-1792152900@sfp-alpes.fr
SUMMARY:Gyorgy SZALOKI (Université Paul Sabatier – Toulouse)
DESCRIPTION:Towards confined gold catalysis\nRésumé : \nGold complexes have been the subject of an intense research over the past decade.[1] The main driving force to this interest is to impart new reactivity to these complexes\, that can be leveraged in catalysis. In addition to the widely used ligand engineering strategy\,[2] the concept of confining gold complexes within supramolecular cages has also shown a great\npotential.[3] Toste et coll. have demonstrated\, that small cationic gold complexes (LAu+\, L = Me3P)\, generated within anionic cages show a markedly different reactivity compared to their non-confined analogues. However\, the small cavity size of the cage (251 Å3) has not allowed to extend this concept to larger complexes (L = tBuP\, NHC) and substrates. Indeed\, one obstacle\nto overcome is the synthesis of large anionic cages\, that is far from being straightforward.\nIn order to design and synthesize large anionic cages\, we have implemented a rational approach combining modellizations and cavity size calculations.[4] As a result\, we have prepared an anionic\, cyclotricatechylene based supramolecular cage 1 with a large cavity (558 Å3).[5] Recently\, we have been studying the host-guest chemistry of this cage\, in order to prepare the confined gold-catalyst (Au+@1\, Figure 1). The catalytic activity of Au+@1 is being studied\, with special attention to the synthetically challenging gold catalyzed macrocyclizations. \nFigure 1. Concept: Using the confinement effect to alter the reactivity of gold complexes. \nAcknowledgements\nThe CNRS\, the ANR and the French Ministry of Higher Education and Research is gratefully acknowledged for funding. \nReferences\n[1] L. Rochigiani\, M. Bochmann Chem. Rev. 2021\, 121\, 8364.\n[2] J. Rodriguez\, G. Szalóki\, E. D. Sosa Carizzo\, N. Saffon-Merceron\, K. Miqueu\, D. Bourissou Angew. Chem. Int. Ed.\, 2020\, 59\, 1511;\n(b) G. Szalóki\, J. Babinot\, V. Martin-Diaconescu\, S. Mallet-Ladeira\, Y. Garcia-Rodeja\, K. Miqueu\, D. Bourissou Chem. Sci. 2022\, 13\, 10499.\n[3] M. Morimoto\, S. M. Bierschenk\, K. T. Xia\, R. G. Bergman\, K. N. Raymond\, D. F. Toste Nat. Catal. 2020\, 3\, 969.\n[4] J. V. S. Guerra\, L. F. G. Alves\, D. Bourissou\, P. S. Lopes-de-Oliveira\, G. Szalóki J. Chem. Inf. Model. 2023\, 63\, 3772.\n[5] Y. Diack\, S. Mallet-Ladeira\, D. Lesage\, J. V. S. Guerra\, D. Bourissou\, G. Szalóki Chem. Commun. 2025\, 61\, 8003 \n_ \nContact : noemie.lalaoui@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/gyorgy-szaloki-universite-paul-sabatier-toulouse/
LOCATION:DCM – Salle C209\, DCM - Bât Chimie Recherche 301 rue de la Chimie\, St Martin d'Hères\, 38400\, France
CATEGORIES:Séminaire
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261016T133000
DTEND;TZID=Europe/Paris:20261016T153000
DTSTAMP:20260911T131722Z
CREATED:20260911T131722Z
LAST-MODIFIED:20260911T131722Z
UID:10000252-1792157400-1792164600@sfp-alpes.fr
SUMMARY:Soutenance de Thèse par Irene SUAREZ ANTUNA (DCM (équipe CIRe))
DESCRIPTION:Bio-inspired strategies for small molecule activation: from photochemical H2 production to electrochemical CO2 reduction\n_ \nContact : Nathalie.Camerino@univ-grenoble-alpes.fr \n 
URL:https://sfp-alpes.fr/event/soutenance-de-these-par-irene-suarez-antuna-dcm-equipe-cire/
LOCATION:Maison Jean Kuntzmann – amphithéâtre\, 110\, rue de la Chimie\, Saint-Martin-d'Hères\, 38400\, France
CATEGORIES:Soutenance,Soutenance de Thèse
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261026T140000
DTEND;TZID=Europe/Paris:20261026T150000
DTSTAMP:20260911T134555Z
CREATED:20260911T134555Z
LAST-MODIFIED:20260911T134555Z
UID:10000253-1793023200-1793026800@sfp-alpes.fr
SUMMARY:Ramón RIAL (Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS)\, Departamento de Física Aplicada\, Universidade de Santiago de Compostela\, Spain)
DESCRIPTION:Dynamic Supramolecular Eutectogels with Reversible Light Driven Reconfiguration\nRésumé : \nDeep eutectic solvents (DESs) constitute a highly tunable class of liquid media formed by the association of two or more components (e.g.\, a hydrogen-bond donor and an organic salt)\, whose extensive hydrogen bonding interactions result in a pronounced depression of the melting point. Their composition-dependent physicochemical properties make DESs particularly attractive for directing the self-assembly of functional soft materials [1\,2]. In this context\, eutectogels (gels formed within DES media)\, offer a versatile platform in which solvent–solute interactions can be exploited to modulate macroscopic material properties beyond those dictated by the gelator alone [3]. \nHerein\, we report a versatile strategy for the design of light-responsive eutectogels with intrinsically tunable mechanical properties. The approach relies on the supramolecular co-assembly of an amphiphilic component with a rationally designed azobenzene derivative engineered for high solubility in water-free DES media. Through complementary characterization across molecular and mesoscale length scales\, we provided a detailed understanding of the heterotypic interactions underlying the formation of elongated\, one-dimensional supramolecular networks. We further establish that photoisomerization of the azobenzene units induces pronounced rearrangements of these networks\, providing a molecular-level mechanism for controlling the material’s hierarchical organization. \nUpon ultraviolet irradiation\, this molecular reconfiguration leads to an abrupt gel-to-sol transition\, effectively erasing the material’s solid-like mechanical response. Subsequent exposure to visible light reverses the process\, restoring the gel state and recovering a mechanically robust network that remains stable during prolonged storage without appreciable loss of performance. Remarkably\, the optically driven transition is highly reversible and cyclable\, enabling repeated switching between gel and sol states without detectable deterioration of structural integrity or mechanical properties. Collectively\, these results demonstrate how molecular photochemical events can be translated into reversible macroscopic mechanical actuation\, establishing DES-based supramolecular eutectogels as promising platforms for dynamically reconfigurable soft matter. \nReferences :\n[1] Hansen\, B. et al.\, Chem. Rev. 2021\, 101\, 1232-1285.\n[2] P. A. Mercadal\, A. González\, A. Beloqui\, L. C. Tomé\, D. Mecerreyes\, M. Calderón and M. L. Picchio\, JACS Au\, 2024\, 4\, 3744-3758.\n[3] A. Sanchez-Fernandez\, J. F. Poon\, A. E. Leung\, S. F. Prevost and C. Dicko\, ACS Nano\, 2024\, 18\, 18314-18326. \nOrsolya Czakkel (College 9 Secretary) \nExternal visitors may ask for a site access to : tellier@ill.fr \nZoom link : https://ill.zoom.us/j/93326326401?pwd=mq7JqMLctpkqw7hIcPWTq6QGt8nGOg.1 – Password : SeminarC3 \n 
URL:https://sfp-alpes.fr/event/ramon-rial-centro-singular-de-investigacion-en-quimica-bioloxica-e-materiais-moleculares-ciqus-departamento-de-fisica-aplicada-universidade-de-santiago-de-compostela-spain/
LOCATION:ILL – Salle de Séminaire (110-111)\, ILL 50 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
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