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DTSTART;TZID=Europe/Paris:20260423T140000
DTEND;TZID=Europe/Paris:20260423T160000
DTSTAMP:20260405T203344
CREATED:20260402T155914Z
LAST-MODIFIED:20260402T155920Z
UID:10000119-1776952800-1776960000@sfp-alpes.fr
SUMMARY:Soutenance de Thèse de Moritz KIRCHNER (IRIG / IBS)
DESCRIPTION:Molecular bases of a multiprotein assembly linking membrane biology to stress adaptation in enterobacteria\nRésumé : \n\nEnteric bacteria encounter a variety of stress factors when infecting their host. This includes but is not limited to acid stress\, oxygen limitation and antibiotic stress. Bacteria counteract such stressors using various stress response systems. A central factor in the stress adaptation of enterobacteria is their cell envelope\, in particular their cell membrane. A system of proteins which has been demonstrated to be involved in multiple stress adaptation pathways is the RavA-ViaA-LdcI triad in Escherichia coli. RavA and ViaA are two proteins with as of yet unknown function that have been shown to sensitise E. coli to aminoglycoside antibiotics under anaerobic conditions. RavA forms a large complex with LdcI\, an inducible lysine decarboxylase which is one of the central enzymes involved in acid stress response of E. coli. Both RavA and ViaA have been shown to bind specific anionic lipids and their lipid binding capacity is strongly linked to their sensitising effect to aminoglycosides.\n​This thesis presents the exploration of the connections these three proteins have to each other and their other binding partners by optical and electron microscopy in order to elucidate how their action leads to antibiotic sensitisation and what role their connection to the cell membrane and acid stress might play in this regard. It is shown that LdcI prefers to localise to the cell periphery to efficiently counteract acid stress and that mutations of its active site lead to large domain movements which might play a crucial role in its enzymatic activity. Furthermore\, an investigation of liposome decoration by RavA and ViaA is presented\, demonstrating the effect they have on membrane shape. In addition\, the first cryo-EM structure of ViaA is presented using helical repeat proteins to stabilise the protein. Finally\, predictions of RavA and ViaA protein-protein interactions in the inner E. coli membrane reveal possible functional targets of the proteins and the implications of these new possible avenues for action are discussed with regard of the microscopy investigations.\n\n—\n​​\n\n\nLes séminaires et soutenances sont ouverts à tous\, notez toutefois que l’accès au campus EPN nécessite un avis de rendez-vous. Merci de remplir ce formulaire  et de l’adresser\, plus de 48h à l’avance\, à ce contact. Pensez à vous munir d’une pièce d’identité le jour de votre visite.
URL:https://sfp-alpes.fr/event/soutenance-de-these-de-moritz-kirchner-irig-ibs/
LOCATION:IBS – Salle des séminaires\, IBS 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Soutenance,Soutenance de Thèse
ORGANIZER;CN="IBS":MAILTO:ibs.seminaires@ibs
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DTSTART;TZID=Europe/Paris:20260428T140000
DTEND;TZID=Europe/Paris:20260428T150000
DTSTAMP:20260405T203344
CREATED:20260326T140308Z
LAST-MODIFIED:20260326T140314Z
UID:10000110-1777384800-1777388400@sfp-alpes.fr
SUMMARY:Elizabeth TILLY (University of New Mexico)
DESCRIPTION:Directional Detection as a Tool for Rare-Event Searches\nRésumé : \nMeasuring the initial scattering angle of a particle track provides powerful discrimination in rare-event searches and can enhance detector characterization. The Migdal effect–characterized by a nuclear recoil and an electron recoil originating from the same vertex–is an inherently directional signal. In this talk\, I will present my work with the Migdal In Galactic Dark mAtter expLoration (MIGDAL) experiment which uses a GEM-based TPC. I will discuss the development of our 3D track reconstruction algorithms and studies exploiting its angular resolution to characterize detector response. I will also discuss measurements of drift properties in negative ion drift gas mixtures\, maximizing noble gas components with the aim of improving spatial resolution for MIGDAL Phase II. Together these demonstrate the power and versatility of precise directional track reconstruction for next-generation rare-event searches. \n— \nHanno Filter (College 3 Secretary) \nExternal visitors may ask for a site access to tellier@ill.fr
URL:https://sfp-alpes.fr/event/elizabeth-tilly-university-of-new-mexico/
LOCATION:ILL – Salle de Séminaire (110-111)\, ILL 50 71 avenue des Martyrs\, Grenoble\, 38042\, France
CATEGORIES:Séminaire
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DTSTART;TZID=Europe/Paris:20260505T090000
DTEND;TZID=Europe/Paris:20260505T100000
DTSTAMP:20260405T203344
CREATED:20260402T153041Z
LAST-MODIFIED:20260402T153041Z
UID:10000117-1777971600-1777975200@sfp-alpes.fr
SUMMARY:Yukiko TAKAHASHI (NIMS\, Japan)
DESCRIPTION:Material development for HAMR and its prospects\nRésumé : \n\n\nWith the rapid expansion of IoT and digital transformation\, data centers demand ever-higher storage densities. Heat-assisted magnetic recording (HAMR) employs L1₀-FePt\, whose magnetic anisotropy is an order of magnitude larger than that of conventional CoCrPt\, enabling ultrahigh-density recording. Achieving areal densities beyond 4 Tbit/in² requires granular films with grain sizes ~4.3 nm and narrow inter-grain pitch with ~1 nm [1]. However\, conventional segregant systems such as FePt-C and FePt-BN have not yet simultaneously satisfied the required microstructural and magnetic criteria.\n​​ To overcome this limitation\, we introduced a data- driven materials design framework using the NIMS Research Data Express (RDE) platform. By collecting experimental datasets and applying machine learning to FePt-C and FePt-BN systems\, we predicted sputtering conditions that led to FePt-BN-C granular films with sub-6 nm grain sizes and coercivities up to 3.7 T. Although iterative prediction cycles improved the microstructure to 4.9 nm grains\, the results also clarified the intrinsic difficulty of meeting all 4 Tbit/in² requirements within this materials system alone.\n​​Beyond materials optimization\, three-dimensional magnetic recording offers an additional pathway toward higher areal density. As a proof of concept\, FePt-C/Ru-C/FePt-C trilayers were fabricated\, demonstrating epitaxial stacking and distinct magnetic switching behaviors arising from different ordering states in the upper and lower FePt layers [2]. Strategies to improve the structural and magnetic quality of the upper layer will be discussed.\n​​\n​​ [1] D. Weller et al.\, IEEE Trans. Magn. 50\, 3100108 (2014).\n​​ [2] P. Tozman et al.\,Acta Mater. 271\, 119869 (2024).\n​​\nMore information : https://www.spintec.fr/seminar-material-development-for-hamr-and-its-prospects/​​\n​\nVisioconference : https://univ-grenoble-alpes-fr.zoom.us/j/98769867024?pwd=dXNnT3RMeThjYStybGVQSUN0TVdJdz09​​\n​​\n​– \n\n\n\n​ Accès : access to CEA require​s an entry au​thorization. Request it : admin.spintec@cea.fr​
URL:https://sfp-alpes.fr/event/yukiko-takahashi-nims-japan/
LOCATION:CEA – Salle de Séminaire IRIG (1005 – 445)\, Laboratoire Irig/Spintec\, salle de séminaire 445\, bâtiment 1005\, CEA-Grenoble\, Grenoble
CATEGORIES:Séminaire
ORGANIZER;CN="IRIG - CEA":MAILTO:odile.rossignol@cea.fr
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