BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//SFP Alpes - ECPv6.18.3.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:SFP Alpes
X-ORIGINAL-URL:https://sfp-alpes.fr
X-WR-CALDESC:Évènements pour SFP Alpes
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20270328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20271031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261110T110000
DTEND;TZID=Europe/Paris:20261110T120000
DTSTAMP:20261104T204118Z
CREATED:20261104T204032Z
LAST-MODIFIED:20261104T204118Z
UID:10000348-1794308400-1794312000@sfp-alpes.fr
SUMMARY:Alexandra COLIN (IRIG\, CEA\, Grenoble\, France)
DESCRIPTION:Dynamics and  scaling of competitive actin architectures\nRésumé : \nCells constantly experience environmental changes requiring a fast adaptation of their different actin structures. However\, the mechanisms governing the size and dynamics of these multiple actin structures remain unknown. Decoupling the various parameters that would provide a complete understanding of these mechanisms is very complicated in a cellular context. This is why we have developed a bottom-up approach to identify the key molecular mechanisms that determine the size and coexistence of multiple competing actin architectures. We used a reconstituted system consisting of purified proteins and substrates to localize actin polymerization in microwells\, enabling us to work with a limited number of components. With this system\, we reconstituted several dynamic actin architectures\, competing for a limited pool of protein\, over a period of multiple hours. This allowed us to gain key insights into physiological functions related to actin turnover. I will show how we used this system to study the limits of scaling in dynamic structures\, as well as the limits of coexistence in actin networks under resource-limited conditions. Finally\, I will show how we can recapitulate these results in a complementary cellular system\, in which we have demonstrated that an increase in spreading area leads to a decrease in overall turnover\, due to a predominance of structures with low turnover. \n_ \nContact : olivier.destaing@univ-grenoble-alpes.fr
URL:https://sfp-alpes.fr/event/alexandra-colin-irig-cea-grenoble-france/
LOCATION:IAB – Salle de séminaire\, IAB Site Santé - Allée des Alpes\, La Tronche\, 38700\, France
CATEGORIES:Séminaire
ORGANIZER;CN="IAB":MAILTO:appaixfl@univ-grenoble-alpes.fr
END:VEVENT
END:VCALENDAR